{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:41:37Z","timestamp":1792885297709,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health\/National Heart, Lung and Blood Institute","doi-asserted-by":"publisher","award":["K23HL123533"],"award-info":[{"award-number":["K23HL123533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health\/National Heart, Lung and Blood Institute","doi-asserted-by":"publisher","award":["PG\/13\/17\/30050"],"award-info":[{"award-number":["PG\/13\/17\/30050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lizzi og Mogens Staal Fonden"},{"name":"NIH\/NHLB","award":["R01HL148439"],"award-info":[{"award-number":["R01HL148439"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Overweight\/obesity are important risk factors for heart failure (HF), however, the pathophysiologic consequences of obesity in patients with acute HF (AHF) are incompletely understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We examined cardiac structure and function, and congestion-related markers in adults hospitalized for AHF across three body mass index (BMI) groups: 18.5\u201324.9\u2005kg\/m2 (normal weight), 25\u201329.9\u2005kg\/m2 (overweight), \u2265 30\u2005kg\/m2 (obese), and based on left ventricular ejection fraction (LVEF) &amp;gt; 40% [HF with mildly reduced\/preserved EF (HFmrEF\/HFpEF)] vs. \u2264 40% [HF with reduced EF (HFrEF)]. Echocardiography, 4-zone lung ultrasound, and patient-reported symptoms were assessed at baseline, and 6-month outcomes (HF hospitalizations and all-cause death) were collected. Among 354 participants (median age 75, 59% men), 36% were normal weight, 29% overweight and 35% obese. Higher BMI was associated with younger age, more comorbidities, a higher proportion of prior HF, and worse patient-reported symptoms. Patients with HFmrEF\/HFpEF were older, more likely female, had a higher BMI and higher proportions of hypertension and atrial fibrillation. Both patients with HFmrEF\/HFpEF and HFrEF had greater biventricular volumes\/area and LV mass, similar degrees of elevated LV filling pressure and lower degrees of pulmonary congestion with higher BMI. The risk of the composite outcome was similar across BMI groups both in the overall cohort and when stratified by LVEF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among patients with AHF, those with overweight\/obesity had greater biventricular volumes\/area and LV mass, similar sonographic evidence of haemodynamic congestion and less pulmonary congestion than those with normal weight. The risk of 6-month HF hospitalization or death was similar across BMI groups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf067","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T14:20:22Z","timestamp":1745850022000},"page":"540-551","source":"Crossref","is-referenced-by-count":2,"title":["The intersection of obesity and acute heart failure: cardiac structure and function and congestion across BMI categories"],"prefix":"10.1093","volume":"14","author":[{"given":"Sofie","family":"B\u00f8gh-S\u00f8rensen","sequence":"first","affiliation":[{"name":"Cardiovascular Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital\u2014Herlev & Gentofte Hospital , Hellerup ,","place":["Denmark"]},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Copenhagen University , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-2129","authenticated-orcid":false,"given":"Ross T","family":"Campbell","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, School of Cardiovascular & Metabolic Health, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L","family":"Claggett","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldrin F","family":"Lewis","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Stanford University School of Medicine , Palo Alto, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran F","family":"Docherty","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, School of Cardiovascular & Metabolic Health, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-2067","authenticated-orcid":false,"given":"Matthew M Y","family":"Lee","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, School of Cardiovascular & Metabolic Health, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zentralklinik Bad Berka , Bad Berka 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