{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:22:23Z","timestamp":1759882943320,"version":"build-2065373602"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The NULL-PLEASE score (Non-shockable rhythm, Unwitnessed arrest, Long no-flow or Long low-flow period, blood pH &amp;lt;7.2, Lactate &amp;gt;7.0\u2005mmol\/L, End-stage renal disease on dialysis, Age \u226585 years, Still resuscitation, and Extracardiac cause) was developed to predict survival in out-of-hospital cardiac arrest (OHCA) patients. Because survival differs between sexes, we aimed to validate NULL-PLEASE separately in men and women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Men and women with return of spontaneous circulation (ROSC) or ongoing cardiopulmonary resuscitation at hospital arrival from 2001 to 2019 were identified using Danish nationwide registries. The primary outcome was 1-day mortality. Secondary outcomes were defined as 30-day mortality and the combination of 1-year mortality or anoxic brain damage. Logistic regression was used for outcome risk estimation (reference: NULL-PLEASE = 0). Interaction analyses were performed between the NULL-PLEASE score and sex. The predictive ability was assessed using area under the receiver operating characteristics (AUCROC) curves. We included 2599 men and 1280 women. One-day mortality for men and women was 36% and 50%; 30-day mortality was 56% and 71%; and 63% and 78% experienced the combined 1-year outcome. AUCROC values for 1-day mortality were for men: 0.828 (95% CI: 0.813\u20130.844); and for women: 0.754 (95% CI: 0.728\u20130.780). Results were similar for secondary outcomes. We found significant interaction between the NULL-PLEASE score and sex: 1-day mortality: P &amp;lt; 0.001, 30-day mortality: P = 0.04, combined outcome: P = 0.09.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In a nationwide OHCA-cohort, the predictive ability of the NULL-PLEASE score was higher in men than in women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf069","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T03:16:43Z","timestamp":1746415003000},"page":"522-530","source":"Crossref","is-referenced-by-count":0,"title":["External validation of the simple NULL-PLEASE clinical score in predicting outcomes in men and women with out-of-hospital cardiac arrest: a nationwide registry-based study"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2705-3367","authenticated-orcid":false,"given":"Christina","family":"Byrne","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo A","family":"Barcella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lukacs","family":"Krogager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Aalborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manan","family":"Pareek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Bundgaard","family":"Ringgren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Aalborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Wissenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-7857","authenticated-orcid":false,"given":"Fredrik","family":"Folke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-402X","authenticated-orcid":false,"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-4743","authenticated-orcid":false,"given":"Jesper","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Zealand Hospital , Hiller\u00f8d ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital , Liverpool ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-8670","authenticated-orcid":false,"given":"Kristian","family":"Kragholm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Aalborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"2025100709314249000_zuaf069-B1","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1016\/j.resuscitation.2016.07.201","article-title":"NULL-PLEASE: a new \u2018futility score\u2019 in the management of survivors of out-of-hospital cardiac arrest","volume":"106","author":"Ahmad","year":"2016","journal-title":"Resuscitation"},{"key":"2025100709314249000_zuaf069-B2","doi-asserted-by":"crossref","first-page":"1464.e13","DOI":"10.1016\/j.amjmed.2017.05.035","article-title":"External validation of the simple NULL-PLEASE 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