{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:32:07Z","timestamp":1777944727139,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cangrelor is used to bridge the gap of insufficient platelet inhibition in patients with out-of-hospital cardiac arrest (OHCA) undergoing percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In a retrospective chart review study, we investigated the incidence of bleeding and stent thrombosis in patients with OHCA undergoing PCI who received either cangrelor and transition to an oral P2Y12 inhibitor or an oral P2Y12 inhibitor alone. Subgroups consisted of patients treated with conventional cardiopulmonary resuscitation (CPR) and extracorporeal CPR. The primary endpoint was Bleeding Academic Research Consortium (BARC) 3\u20135 bleeding at 30 days. Between January 2016 and March 2025, 414 patients were included of which 267 received cangrelor and an oral P2Y12 inhibitor and 147 received an oral P2Y12 inhibitor alone. BARC 3\u20135 bleeding at 30 days occurred at a similar rate in the cangrelor group and the oral P2Y12 inhibitor group (18.4% vs. 19.0%, respectively; adjusted OR, 0.79; 95% CI, 0.45\u20131.39). BARC 3\u20135 bleeding at 6, 24 and 48\u2005h was similar between the cangrelor group and the oral P2Y12 inhibitor group in patients treated with conventional and extracorporeal CPR. In patients treated with extracorporeal CPR, stent thrombosis occurred less frequently in the cangrelor group compared with the oral P2Y12 inhibitor group (2.1% vs. 4.5%, respectively; adjusted OR, 0.32, 95% CI, 0.03\u20133.14), but without reaching statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with OHCA undergoing PCI, BARC 3\u20135 bleeding occurred at a similar rate in patients receiving either cangrelor and transition to an oral P2Y12 inhibitor or an oral P2Y12 inhibitor alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf082","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T07:55:00Z","timestamp":1749196500000},"page":"267-275","source":"Crossref","is-referenced-by-count":4,"title":["Bleeding complications in patients with out-of-hospital cardiac arrest treated with cangrelor and oral P2Y12 inhibitors"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-7178","authenticated-orcid":false,"given":"Georg","family":"Gelbenegger","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Julia","family":"Lipa","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Division of Cardiology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anselm","family":"Jorda","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-6149","authenticated-orcid":false,"given":"Robert","family":"Zilberszac","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Division of Cardiology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Division of Cardiology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-4473","authenticated-orcid":false,"given":"Thomas","family":"Staudinger","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Zauner","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Holzer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-2428","authenticated-orcid":false,"given":"Guy","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Division of Cardiology, Medical University of Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Plank","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Division of Cardiology, Medical University of Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-2692","authenticated-orcid":false,"given":"Irene M","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Division of Cardiology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Jilma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-1635","authenticated-orcid":false,"given":"Jolanta M","family":"Siller-Matula","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Division of Cardiology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"2026042812515893900_zuaf082-B1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/ldx011","article-title":"Sudden cardiac death","volume":"122","author":"Kandala","year":"2017","journal-title":"Br Med Bull"},{"key":"2026042812515893900_zuaf082-B2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.resuscitation.2017.06.006","article-title":"Etiological diagnoses of out-of-hospital cardiac arrest survivors admitted to the intensive care unit: insights from a French 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