{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T06:50:15Z","timestamp":1766386215812,"version":"3.48.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Patients with advanced conduction disorders exhibit diverse haemodynamic profiles, from cardiogenic shock to severe hypertension. Peripheral vascular resistance (PVR) significantly contributes to compensatory mechanisms during bradycardia. This study aimed to assess the haemodynamic responses of patients presenting with high-degree atrioventricular (AV) block.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively analyzed 261 consecutive patients with advanced conduction disorders who underwent pacemaker implantation from October 2020 to December 2022. Patients were classified into three groups: normotensive (&amp;lt;160\u2005mmHg), hypertensive (\u2265160\u2005mmHg), and unstable (requiring emergent temporary pacing). Additionally, 73 stable patients underwent non-invasive haemodynamic assessment. Of 261 patients, 99 (37.9%) were normotensive, 118 (45.2%) hypertensive, and 44 (16.9%) unstable. Hypertensive patients frequently had hypertension history (77.1%), presented with higher escape rhythms (39.1 \u00b1 6.7 vs. 31.5 \u00b1 10.4 and 38.1 \u00b1 9.9 in unstable and normotensive patients, respectively), and exhibited higher ejection fractions (58.2 \u00b1 8 vs. 53.2 \u00b1 12 and 53.9 \u00b1 11, respectively). They demonstrated fewer low cardiac output signs, including acute kidney injury and elevated lactate levels. PVR was significantly elevated in the hypertensive group. The unstable group experienced the highest 30-day mortality and higher 1-year mortality, though the latter did not reach statistical significance. Factors independently associated with a hypertensive response included higher heart rate, higher ejection fraction, and calcium channel blocker pre-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Haemodynamic presentations in high-degree AV block are heterogeneous. A hypertensive response represents a distinct clinical phenotype characterized by preserved cardiac function, higher escape rhythms, increased PVR, and fewer end-organ hypoperfusion signs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf103","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T11:54:23Z","timestamp":1754049263000},"page":"654-663","source":"Crossref","is-referenced-by-count":0,"title":["Hypertensive vs. normotensive blood pressure response to advanced conduction disorders: comparison of baseline non-invasive haemodynamic evaluation"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2523-6469","authenticated-orcid":false,"given":"Katia","family":"Orvin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Rabin Medical Center , Jabotinski St. 39, Petah Tikva 4941492 ,","place":["Israel"]},{"name":"Gray Faculty of Medicine and Health Science, Tel Aviv University, 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