{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:01:37Z","timestamp":1792191697110,"version":"4.4.0"},"reference-count":141,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Venous thromboembolism (VTE), comprised of deep vein thrombosis (DVT) and pulmonary embolism (PE), remains a significant public health burden in the USA with an estimated 1 200 000 VTE cases in 2020. Atherothrombosis refers to thrombosis in the setting of atherosclerotic cardiovascular disease and includes type I myocardial infarction (MI), ischaemic stroke, and acute limb events with an estimated 720 000 MIs annually in the USA. Despite the historical view of VTE and atherothrombosis as unrelated entities recognized by \u2018red vs. white clots\u2019, these conditions are closely interconnected and share many pathophysiological features and clinical risk factors. This review provides a critical appraisal of the current evidence for the relationship between VTE and atherothrombosis, exploring potential mechanisms and risk factors linking the disorders, recent discoveries from basic and translational research, clinical investigation highlighting their commonalities, as well as the therapies that address both.<\/jats:p>","DOI":"10.1093\/ehjacc\/zuaf109","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T11:22:20Z","timestamp":1755429740000},"page":"756-768","source":"Crossref","is-referenced-by-count":2,"title":["The link between venous thromboembolism and atherothrombosis: epidemiology, pathophysiology, and implications for clinical care"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-7514","authenticated-orcid":false,"given":"Antoine","family":"Bejjani","sequence":"first","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]},{"name":"Department of Internal Medicine, University of Pittsburgh Medical Center , Pittsburgh, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candrika D","family":"Khairani","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]},{"name":"Department of Internal Medicine, Rochester General Hospital , Rochester, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darsiya","family":"Krishnathasan","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]},{"name":"Department of Internal Medicine, Beth Israel Deaconess Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Sato","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassil","family":"Bacare","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scimeca","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Tristani","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]},{"name":"Frank H. Netter MD School of Medicine, Quinnipiac University , North Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Armero","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Porio","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]},{"name":"Department of Internal Medicine, YNHH\/Yale Center for Outcomes Research and Evaluation (CORE) , New Haven, CT ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-2983","authenticated-orcid":false,"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston 02115, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"2026031015535182400_zuaf109-B1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jama.295.2.180","article-title":"International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis","volume":"295","author":"Bhatt","year":"2006","journal-title":"JAMA"},{"key":"2026031015535182400_zuaf109-B2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ncpcardio0310","article-title":"Atherothrombosis as a systemic, often silent, disease","volume":"2","author":"Fuster","year":"2005","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"2026031015535182400_zuaf109-B3","doi-asserted-by":"crossref","first-page":"e16481","DOI":"10.1111\/ene.16481","article-title":"Global, regional, and national epidemiology of ischemic stroke from 1990 to 2021","volume":"31","author":"Hou","year":"2024","journal-title":"Eur J Neurol"},{"key":"2026031015535182400_zuaf109-B4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1001\/jamaneurol.2024.0190","article-title":"Burden of ischemic and hemorrhagic stroke across the US from 1990 to 2019","volume":"81","author":"Renedo","year":"2024","journal-title":"JAMA Neurol"},{"key":"2026031015535182400_zuaf109-B5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.avsg.2024.06.032","article-title":"Contemporary national incidence and outcomes of acute limb ischemia","volume":"110","author":"Jarosinski","year":"2025","journal-title":"Ann Vasc Surg"},{"key":"2026031015535182400_zuaf109-B6","first-page":"e41","article-title":"2025 heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B7","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"Falk","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B8","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1160\/TH16-03-0205","article-title":"Current incidence of venous thromboembolism and comparison with 1998: a community-based study in western France","volume":"116","author":"Delluc","year":"2016","journal-title":"Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.thromres.2022.04.014","article-title":"Incidence and risk factors of venous thromboembolism in men and women","volume":"214","author":"Lind","year":"2022","journal-title":"Thromb Res"},{"key":"2026031015535182400_zuaf109-B11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s11239-019-01966-y","article-title":"Venous thromboembolism 2011\u20132018 in Stockholm: a demographic study","volume":"48","author":"Wandell","year":"2019","journal-title":"J Thromb Thrombolysis"},{"key":"2026031015535182400_zuaf109-B12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1160\/TH14-06-0563","article-title":"Epidemiology and pathophysiology of venous thromboembolism: similarities with atherothrombosis and the role of inflammation","volume":"113","author":"Riva","year":"2015","journal-title":"Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur Heart J"},{"key":"2026031015535182400_zuaf109-B14","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1161\/CIRCULATIONAHA.110.951236","article-title":"Venous thromboembolism and atherothrombosis: an integrated approach","volume":"121","author":"Piazza","year":"2010","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejim.2012.02.008","article-title":"Association between venous and arterial thrombosis: clinical implications","volume":"23","author":"Franchini","year":"2012","journal-title":"Eur J Intern Med"},{"key":"2026031015535182400_zuaf109-B16","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.09.009","article-title":"Leducq transatlantic network on A. Inflammation in atherosclerosis: from pathophysiology to practice","volume":"54","author":"Libby","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B17","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.jacc.2018.08.1043","article-title":"Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week","volume":"72","author":"Libby","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cgh.2007.09.016","article-title":"The incidence of arterial thromboembolic diseases in inflammatory bowel disease: a population-based study","volume":"6","author":"Bernstein","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026031015535182400_zuaf109-B19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.thromres.2022.09.009","article-title":"Incidence and impact of venous thromboembolism in hospitalized patients with Crohn's disease","volume":"219","author":"Keller","year":"2022","journal-title":"Thromb Res"},{"key":"2026031015535182400_zuaf109-B20","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.14309\/ajg.0000000000001237","article-title":"Persistently high rate of venous thromboembolic disease in inflammatory bowel disease: a population-based study","volume":"116","author":"Bernstein","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"2026031015535182400_zuaf109-B21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/annrheumdis-2020-218419","article-title":"Risk of venous thromboembolism in rheumatoid arthritis, and its association with disease activity: a nationwide cohort study from Sweden","volume":"80","author":"Molander","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"2026031015535182400_zuaf109-B22","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2011-200726","article-title":"Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"71","author":"Avina-Zubieta","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2026031015535182400_zuaf109-B23","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood-2018-04-848333","article-title":"Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome","volume":"132","author":"Pengo","year":"2018","journal-title":"Blood"},{"key":"2026031015535182400_zuaf109-B24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.7326\/M19-0291","article-title":"Rivaroxaban versus vitamin K antagonist in antiphospholipid syndrome: a randomized noninferiority trial","volume":"171","author":"Ordi-Ros","year":"2019","journal-title":"Ann Intern Med"},{"key":"2026031015535182400_zuaf109-B25","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1182\/bloodadvances.2021005808","article-title":"Apixaban compared with warfarin to prevent thrombosis in thrombotic antiphospholipid syndrome: a randomized trial","volume":"6","author":"Woller","year":"2022","journal-title":"Blood Adv"},{"key":"2026031015535182400_zuaf109-B26","doi-asserted-by":"crossref","first-page":"102424","DOI":"10.1016\/j.rpth.2024.102424","article-title":"Direct oral anticoagulants for treatment of venous thrombosis: illustrated review of appropriate use","volume":"8","author":"Khairani","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B27","doi-asserted-by":"crossref","first-page":"109213","DOI":"10.1016\/j.thromres.2024.109213","article-title":"Risks of major arterial and venous thrombotic diseases after hospitalisation for influenza, pneumonia, and COVID-19: a population-wide cohort in 2.6 million people in Wales","volume":"245","author":"Keene","year":"2025","journal-title":"Thromb Res"},{"key":"2026031015535182400_zuaf109-B28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1056\/NEJMoa1702090","article-title":"Acute myocardial infarction after laboratory-confirmed influenza infection","volume":"378","author":"Kwong","year":"2018","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"key":"2026031015535182400_zuaf109-B30","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.jacc.2020.04.031","article-title":"COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review","volume":"75","author":"Bikdeli","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/ATVBAHA.122.318232","article-title":"Cardiovascular disease and thrombosis in HIV infection","volume":"43","author":"Perkins","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026031015535182400_zuaf109-B32","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1161\/CIRCRESAHA.124.323891","article-title":"Inflammation in HIV and its impact on atherosclerotic cardiovascular disease","volume":"134","author":"Obare","year":"2024","journal-title":"Circ Res"},{"key":"2026031015535182400_zuaf109-B33","doi-asserted-by":"crossref","first-page":"e285-e350","DOI":"10.1016\/j.jacc.2018.11.003","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"73","author":"Grundy","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1182\/blood-2009-03-210179","article-title":"Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation","volume":"115","author":"Funderburg","year":"2010","journal-title":"Blood"},{"key":"2026031015535182400_zuaf109-B35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jaccao.2021.03.001","article-title":"Venous and arterial thromboembolism in patients with cancer: JACC: cardioOncology state-of-the-art review","volume":"3","author":"Gervaso","year":"2021","journal-title":"JACC CardioOncol"},{"key":"2026031015535182400_zuaf109-B36","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jacc.2017.06.047","article-title":"Risk of arterial thromboembolism in patients with cancer","volume":"70","author":"Navi","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1160\/TH16-08-0615","article-title":"Cancer-associated venous thromboembolism: burden, mechanisms, and management","volume":"117","author":"Ay","year":"2017","journal-title":"Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B38","doi-asserted-by":"crossref","first-page":"e12763","DOI":"10.1002\/rth2.12763","article-title":"Hormonal therapies and venous thrombosis: considerations for prevention and management","volume":"6","author":"Lavasseur","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B39","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1002\/cncr.24508","article-title":"Tamoxifen treatment and risk of deep venous thrombosis and pulmonary embolism: a Danish population-based cohort study","volume":"115","author":"Hernandez","year":"2009","journal-title":"Cancer"},{"key":"2026031015535182400_zuaf109-B40","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jacc.2014.02.529","article-title":"Pre-eclampsia and future cardiovascular risk among women: a review","volume":"63","author":"Ahmed","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B41","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/AOG.0000000000005569","article-title":"Adverse pregnancy outcomes and predicted 30-year risk of maternal cardiovascular disease 2\u20137 years after delivery","volume":"143","author":"Venkatesh","year":"2024","journal-title":"Obstet Gynecol"},{"key":"2026031015535182400_zuaf109-B42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/jama.2022.24093","article-title":"Association between history of adverse pregnancy outcomes and coronary artery disease assessed by coronary computed tomography angiography","volume":"329","author":"Lawesson S","year":"2023","journal-title":"JAMA"},{"key":"2026031015535182400_zuaf109-B43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajog.2023.03.034","article-title":"Hypertensive disorders of pregnancy and long-term risk of maternal stroke-a systematic review and meta-analysis","volume":"229","author":"Brohan","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"2026031015535182400_zuaf109-B44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.thromres.2018.10.023","article-title":"Testosterone therapy and venous thromboembolism: a systematic review and meta-analysis","volume":"172","author":"Houghton","year":"2018","journal-title":"Thromb Res"},{"key":"2026031015535182400_zuaf109-B45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa2215025","article-title":"Cardiovascular safety of testosterone-replacement therapy","volume":"389","author":"Lincoff","year":"2023","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B46","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/jamainternmed.2019.5135","article-title":"Association of testosterone therapy with risk of venous thromboembolism among men with and without hypogonadism","volume":"180","author":"Walker","year":"2020","journal-title":"JAMA Intern Med"},{"key":"2026031015535182400_zuaf109-B47","doi-asserted-by":"crossref","first-page":"i5968","DOI":"10.1136\/bmj.i5968","article-title":"Testosterone treatment and risk of venous thromboembolism: population based case-control study","volume":"355","author":"Martinez","year":"2016","journal-title":"BMJ"},{"key":"2026031015535182400_zuaf109-B48","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1182\/hematology.2024000592","article-title":"Gender-affirming hormone therapy in the transgender patient: influence on thrombotic risk","volume":"2024","author":"King","year":"2024","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"2026031015535182400_zuaf109-B49","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1182\/blood.V99.8.2720","article-title":"A prospective study of venous thromboembolism in relation to factor V Leiden and related factors","volume":"99","author":"Folsom","year":"2002","journal-title":"Blood"},{"key":"2026031015535182400_zuaf109-B50","doi-asserted-by":"crossref","first-page":"330","DOI":"10.7326\/0003-4819-140-5-200403020-00008","article-title":"Factor V Leiden and the risk for venous thromboembolism in the adult Danish population","volume":"140","author":"Juul","year":"2004","journal-title":"Ann Intern Med"},{"key":"2026031015535182400_zuaf109-B51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7326\/0003-4819-129-2-199807150-00003","article-title":"Increased risk for venous thrombosis in carriers of the prothrombin G\u2013&gt;A20210 gene variant","volume":"129","author":"Margaglione","year":"1998","journal-title":"Ann Intern Med"},{"key":"2026031015535182400_zuaf109-B52","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jacc.2024.02.031","article-title":"Lipoprotein(a) and long-term cardiovascular risk in a multi-ethnic pooled prospective cohort","volume":"83","author":"Wong","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B53","doi-asserted-by":"crossref","first-page":"e0149427","DOI":"10.1371\/journal.pone.0149427","article-title":"Apolipoprotein(a) kringle-IV type 2 copy number variation is associated with venous thromboembolism","volume":"11","author":"Sticchi","year":"2016","journal-title":"PLoS One"},{"key":"2026031015535182400_zuaf109-B54","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1161\/CIRCULATIONAHA.120.045826","article-title":"Lipoprotein(a) in Alzheimer, atherosclerotic, cerebrovascular, thrombotic, and valvular disease: Mendelian randomization investigation","volume":"141","author":"Larsson","year":"2020","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B55","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1055\/s-0036-1598002","article-title":"Lipoprotein(a) as a risk factor for venous thromboembolism: a systematic review and meta-analysis of the literature","volume":"43","author":"Dentali","year":"2017","journal-title":"Semin Thromb Hemost"},{"key":"2026031015535182400_zuaf109-B56","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41569-023-00947-2","article-title":"Lipoprotein(a), platelet function and cardiovascular disease","volume":"21","author":"Bhatia","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"2026031015535182400_zuaf109-B57","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1194\/jlr.R060582","article-title":"Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease?","volume":"57","author":"Boffa","year":"2016","journal-title":"J Lipid Res"},{"key":"2026031015535182400_zuaf109-B58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/ATVBAHA.120.315445","article-title":"Heparin-induced thrombocytopenia: a focus on thrombosis","volume":"41","author":"Arepally","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026031015535182400_zuaf109-B59","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/S2352-3026(21)00306-9","article-title":"Vaccine-induced immune thrombotic thrombocytopenia","volume":"9","author":"Klok","year":"2022","journal-title":"Lancet Haematol"},{"key":"2026031015535182400_zuaf109-B60","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.cir.0000442015.53336.12","article-title":"Executive summary: heart disease and stroke statistics\u20142014 update","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B61","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.116.024507","article-title":"Association of traditional cardiovascular risk factors with venous thromboembolism","volume":"135","author":"Mahmoodi","year":"2017","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B62","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/ATVBAHA.114.304960","article-title":"Relationship of cigarette smoking with inflammation and subclinical vascular disease","volume":"35","author":"McEvoy","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026031015535182400_zuaf109-B63","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1538-7836.2009.03490.x","article-title":"Smoking and venous thromboembolism: a Danish follow-up study","volume":"7","author":"Severinsen","year":"2009","journal-title":"J Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B64","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.jacc.2019.03.009","article-title":"2019 ACC\/AHA Guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines","volume":"74","author":"Arnett","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B65","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air pollution and cardiovascular disease: JACC state-of-the-art review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026031015535182400_zuaf109-B66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12940-022-00834-2","article-title":"Long-term exposure to air pollution and risk of venous thromboembolism in a large administrative cohort","volume":"21","author":"Renzi","year":"2022","journal-title":"Environ Health"},{"key":"2026031015535182400_zuaf109-B67","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1111\/jgs.14964","article-title":"Functional impairment and risk of venous thrombosis in older adults","volume":"65","author":"Engbers","year":"2017","journal-title":"J Am Geriatr Soc"},{"key":"2026031015535182400_zuaf109-B68","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/CIRCULATIONAHA.106.641688","article-title":"Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the longitudinal investigation of thromboembolism etiology","volume":"115","author":"Steffen","year":"2007","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B69","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.numecd.2017.05.004","article-title":"The PREDIMED trial, Mediterranean diet and health outcomes: how strong is the evidence?","volume":"27","author":"Guasch-Ferre","year":"2017","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2026031015535182400_zuaf109-B70","doi-asserted-by":"crossref","first-page":"e003197","DOI":"10.1161\/JAHA.116.003197","article-title":"Associations of trauma exposure and posttraumatic stress symptoms with venous thromboembolism over 22 years in women","volume":"5","author":"Sumner","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2026031015535182400_zuaf109-B71","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1538-7836.2007.02857.x","article-title":"Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men","volume":"6","author":"Rosengren","year":"2008","journal-title":"J Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B72","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa022157","article-title":"An association between atherosclerosis and venous thrombosis","volume":"348","author":"Prandoni","year":"2003","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B73","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1024\/0301-1526\/a001029","article-title":"Peripheral artery disease and the risk of venous thromboembolism","volume":"51","author":"Sykora","year":"2022","journal-title":"Vasa"},{"key":"2026031015535182400_zuaf109-B74","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCULATIONAHA.117.031062","article-title":"Frequency, predictors, and impact of combined antiplatelet therapy on venous thromboembolism in patients with symptomatic atherosclerosis","volume":"137","author":"Cavallari","year":"2018","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B75","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(07)61745-0","article-title":"Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study","volume":"370","author":"Sorensen","year":"2007","journal-title":"Lancet"},{"key":"2026031015535182400_zuaf109-B76","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41588-019-0519-3","article-title":"Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease","volume":"51","author":"Klarin","year":"2019","journal-title":"Nat Genet"},{"key":"2026031015535182400_zuaf109-B77","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1160\/TH14-10-0868","article-title":"Diabetes increases the risk of deep-vein thrombosis and pulmonary embolism. A population-based cohort study","volume":"114","author":"Chung","year":"2015","journal-title":"Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B78","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.amjmed.2011.12.004","article-title":"Venous thromboembolism in patients with diabetes mellitus","volume":"125","author":"Piazza","year":"2012","journal-title":"Am J Med"},{"key":"2026031015535182400_zuaf109-B79","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1513\/AnnalsATS.201907-518OC","article-title":"Metabolic syndrome increases risk of venous thromboembolism recurrence after acute pulmonary embolism","volume":"17","author":"Stewart","year":"2020","journal-title":"Ann Am Thorac Soc"},{"key":"2026031015535182400_zuaf109-B80","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1538-7836.2009.03295.x","article-title":"Metabolic syndrome and risk of venous thromboembolism: longitudinal investigation of thromboembolism etiology","volume":"7","author":"Steffen","year":"2009","journal-title":"J Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B81","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1172\/JCI60229","article-title":"New insights into the mechanisms of venous thrombosis","volume":"122","author":"Mackman","year":"2012","journal-title":"J Clin Invest"},{"key":"2026031015535182400_zuaf109-B82","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.21037\/cdt.2017.10.14","article-title":"May-thurner: diagnosis and endovascular management","volume":"7","author":"Knuttinen","year":"2017","journal-title":"Cardiovasc Diagn Ther"},{"key":"2026031015535182400_zuaf109-B83","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.21037\/cdt.2017.10.08","article-title":"Deep venous thrombosis in pregnancy: incidence, pathogenesis and endovascular management","volume":"7","author":"Devis","year":"2017","journal-title":"Cardiovasc Diagn Ther"},{"key":"2026031015535182400_zuaf109-B84","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1177\/1358863X18755927","article-title":"Hypercoagulable states in arterial and venous thrombosis: when, how, and who to test?","volume":"23","author":"Carroll","year":"2018","journal-title":"Vasc Med"},{"key":"2026031015535182400_zuaf109-B85","doi-asserted-by":"crossref","first-page":"e236530","DOI":"10.1001\/jamanetworkopen.2023.6530","article-title":"Prevalence of antiphospholipid antibodies and association with incident cardiovascular events","volume":"6","author":"Zuo","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2026031015535182400_zuaf109-B86","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12959-024-00610-x","article-title":"D-dimer and fibrinogen indicate ischemic risk in patients with atrial fibrillation after percutaneous coronary intervention","volume":"22","author":"Gjermeni","year":"2024","journal-title":"Thromb J"},{"key":"2026031015535182400_zuaf109-B87","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jth.13911","article-title":"Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis","volume":"16","author":"Iba","year":"2018","journal-title":"J Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B88","doi-asserted-by":"publisher","DOI":"10.1055\/a-2523-1821","article-title":"Recent advances in immunothrombosis and thromboinflammation","author":"Kaiser","journal-title":"Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B89","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.306853","article-title":"Cross talk pathways between coagulation and inflammation","volume":"118","author":"Foley","year":"2016","journal-title":"Circ Res"},{"key":"2026031015535182400_zuaf109-B90","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1161\/ATVBAHA.119.312463","article-title":"Neutrophil extracellular traps: villains and targets in arterial, venous, and cancer-associated thrombosis","volume":"39","author":"Thalin","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026031015535182400_zuaf109-B91","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.123.321750","article-title":"NETs-Induced thrombosis impacts on cardiovascular and chronic kidney disease","volume":"132","author":"Thakur","year":"2023","journal-title":"Circ Res"},{"key":"2026031015535182400_zuaf109-B92","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fimmu.2016.00236","article-title":"The emerging role of NETs in venous thrombosis and immunothrombosis","volume":"7","author":"Kimball","year":"2016","journal-title":"Front Immunol"},{"key":"2026031015535182400_zuaf109-B93","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fped.2018.00142","article-title":"The role of inflammation in venous thromboembolism","volume":"6","author":"Branchford","year":"2018","journal-title":"Front Pediatr"},{"key":"2026031015535182400_zuaf109-B94","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1538-7836.2004.00689.x","article-title":"Activation of innate immunity in patients with venous thrombosis: the Leiden thrombophilia study","volume":"2","author":"Reitsma","year":"2004","journal-title":"J Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B95","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1001\/jama.288.16.1994","article-title":"Exercise type and intensity in relation to coronary heart disease in men","volume":"288","author":"Tanasescu","year":"2002","journal-title":"JAMA"},{"key":"2026031015535182400_zuaf109-B96","first-page":"CD001800","article-title":"Exercise-based cardiac rehabilitation for coronary heart disease","volume":"11","author":"Dibben","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"2026031015535182400_zuaf109-B97","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1111\/jth.14287","article-title":"Repeated assessments of physical activity and risk of incident venous thromboembolism","volume":"16","author":"Evensen","year":"2018","journal-title":"J Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B98","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1001\/jama.290.1.86","article-title":"Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review","volume":"290","author":"Critchley","year":"2003","journal-title":"JAMA"},{"key":"2026031015535182400_zuaf109-B99","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B100","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/S0140-6736(22)00122-2","article-title":"Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial","volume":"399","author":"Delgado-Lista","year":"2022","journal-title":"Lancet"},{"key":"2026031015535182400_zuaf109-B101","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/CIRCULATIONAHA.121.057042","article-title":"Influenza vaccination after myocardial infarction: a randomized, double-blind, placebo-controlled, multicenter trial","volume":"144","author":"Frobert","year":"2021","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B102","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1160\/TH09-04-0222","article-title":"Association of influenza vaccination with reduced risk of venous thromboembolism","volume":"102","author":"Zhu","year":"2009","journal-title":"Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B103","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(09)60503-1","article-title":"Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials","volume":"373","author":"Antithrombotic Trialists C","year":"2009","journal-title":"Lancet"},{"key":"2026031015535182400_zuaf109-B104","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa2205973","article-title":"Aspirin or low-molecular-weight heparin for thromboprophylaxis after a fracture","volume":"388","author":"Major Extremity Trauma Research C","year":"2023","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B105","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1001\/jama.2022.13416","article-title":"Effect of aspirin vs enoxaparin on symptomatic venous thromboembolism in patients undergoing hip or knee arthroplasty: the CRISTAL randomized trial","volume":"328","author":"Group CS","year":"2022","journal-title":"JAMA"},{"key":"2026031015535182400_zuaf109-B106","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(00)02110-3","article-title":"Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: pulmonary embolism prevention (PEP) trial","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"2026031015535182400_zuaf109-B107","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJMoa1210384","article-title":"Low-dose aspirin for preventing recurrent venous thromboembolism","volume":"367","author":"Brighton","year":"2012","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B108","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa1114238","article-title":"Aspirin for preventing the recurrence of venous thromboembolism","volume":"366","author":"Becattini","year":"2012","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B109","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1161\/CIRCULATIONAHA.114.008828","article-title":"Aspirin for the prevention of recurrent venous thromboembolism: the INSPIRE collaboration","volume":"130","author":"Simes","year":"2014","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B110","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"2026031015535182400_zuaf109-B111","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1056\/NEJMoa1306638","article-title":"Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism","volume":"369","author":"Hokusai","year":"2013","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B112","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1007903","article-title":"Oral rivaroxaban for symptomatic venous thromboembolism","volume":"363","author":"Investigators","year":"2010","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B113","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa0906598","article-title":"Dabigatran versus warfarin in the treatment of acute venous thromboembolism","volume":"361","author":"Schulman","year":"2009","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B114","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1302507","article-title":"Oral apixaban for the treatment of acute venous thromboembolism","volume":"369","author":"Agnelli","year":"2013","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B115","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1105819","article-title":"Apixaban with antiplatelet therapy after acute coronary syndrome","volume":"365","author":"Alexander","year":"2011","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B116","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa1112277","article-title":"Rivaroxaban in patients with a recent acute coronary syndrome","volume":"366","author":"Mega","year":"2012","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B117","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1056\/NEJMoa1709118","article-title":"Rivaroxaban with or without aspirin in stable cardiovascular disease","volume":"377","author":"Eikelboom","year":"2017","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B118","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1056\/NEJMoa2000052","article-title":"Rivaroxaban in peripheral artery disease after revascularization","volume":"382","author":"Bonaca","year":"2020","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B119","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/CIRCULATIONAHA.124.073050","article-title":"Aspirin plus rivaroxaban versus rivaroxaban alone for the prevention of venous stent thrombosis among patients with post-thrombotic syndrome: the multicenter, multinational, randomized, open-label ARIVA trial","volume":"151","author":"Barco","year":"2025","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B120","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1161\/CIRCULATIONAHA.122.059405","article-title":"Rivaroxaban 2.5\u2005mg twice daily plus aspirin reduces venous thromboembolism in patients with chronic atherosclerosis","volume":"145","author":"Pogosova","year":"2022","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B121","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(09)60738-8","article-title":"Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial","volume":"374","author":"Mega","year":"2009","journal-title":"Lancet"},{"key":"2026031015535182400_zuaf109-B122","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay between inflammation and thrombosis in cardiovascular pathology","volume":"18","author":"Stark","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2026031015535182400_zuaf109-B123","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B124","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMoa1600176","article-title":"Cholesterol lowering in intermediate-risk persons without cardiovascular disease","volume":"374","author":"Yusuf","year":"2016","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B125","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B126","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJMoa1809798","article-title":"Low-dose methotrexate for the prevention of atherosclerotic events","volume":"380","author":"Ridker","year":"2019","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B127","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B128","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in patients with chronic coronary disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B129","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJMoa2405922","article-title":"Colchicine in acute myocardial infarction","volume":"392","author":"Jolly","year":"2025","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B130","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1056\/NEJMoa0900241","article-title":"A randomized trial of rosuvastatin in the prevention of venous thromboembolism","volume":"360","author":"Glynn","year":"2009","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B131","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1161\/CIRCULATIONAHA.120.046397","article-title":"The effect of PCSK9 (proprotein convertase subtilisin\/kexin type 9) inhibition on the risk of venous thromboembolism","volume":"141","author":"Marston","year":"2020","journal-title":"Circulation"},{"key":"2026031015535182400_zuaf109-B132","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jth.15537","article-title":"Statins for venous event reduction in patients with venous thromboembolism: a multicenter randomized controlled pilot trial assessing feasibility","volume":"20","author":"Delluc","year":"2022","journal-title":"J Thromb Haemost"},{"key":"2026031015535182400_zuaf109-B133","first-page":"1344","article-title":"Colchicine and risk of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials","volume":"40","author":"Wang","year":"2024","journal-title":"Can J Cardiol"},{"key":"2026031015535182400_zuaf109-B134","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1093\/eurheartj\/ehae361","article-title":"Lipid lowering for prevention of venous thromboembolism: a network meta-analysis","volume":"45","author":"Farmakis","year":"2024","journal-title":"Eur Heart J"},{"key":"2026031015535182400_zuaf109-B135","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJMoa2405922","article-title":"Colchicine in acute myocardial infarction","volume":"392","author":"Jolly","year":"2024","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B136","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials","volume":"376","author":"Cholesterol Treatment Trialists C","year":"2010","journal-title":"Lancet"},{"key":"2026031015535182400_zuaf109-B137","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/cvr\/cvab078","article-title":"Rosuvastatin for the prevention of venous thromboembolism: a pooled analysis of the HOPE-3 and JUPITER randomized controlled trials","volume":"118","author":"Joseph","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2026031015535182400_zuaf109-B138","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1056\/NEJMoa1410489","article-title":"Ezetimibe added to statin therapy after acute coronary syndromes","volume":"372","author":"Cannon","year":"2015","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B139","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1056\/NEJMoa1801174","article-title":"Alirocumab and cardiovascular outcomes after acute coronary syndrome","volume":"379","author":"Schwartz","year":"2018","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B140","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med"},{"key":"2026031015535182400_zuaf109-B141","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1093\/eurheartj\/ehae492","article-title":"From arteries to veins: the expanding role of lipid-lowering drugs in preventing thrombosis","volume":"45","author":"Nopp","year":"2024","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal: Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article-pdf\/doi\/10.1093\/ehjacc\/zuaf109\/64079498\/zuaf109.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/14\/12\/756\/64079498\/zuaf109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/14\/12\/756\/64079498\/zuaf109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T19:54:14Z","timestamp":1773172454000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/14\/12\/756\/8237535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":141,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,8,19]]},"published-print":{"date-parts":[[2026,1,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuaf109","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,8,19]]}}}