{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:46:54Z","timestamp":1793094414951,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Abbott Medical (Schweiz) AG"},{"name":"Amarin AG"},{"name":"Amgen AG"},{"name":"AstraZeneca AG"},{"name":"Bayer (Schweiz) AG"},{"name":"Biotronik (Schweiz) AG"},{"name":"Boston Scientific AG"},{"name":"B. Braun Medical AG"},{"name":"Cordis-Cardinal Health GmbH"},{"name":"Daiichi-Sankyo (Schweiz) AG"},{"name":"Medtronic AG"},{"name":"Novartis Pharma Schweiz AG"},{"name":"Pfizer\/BMS"},{"name":"SIS Medical AG"},{"name":"Terumo (Schweiz) AG"},{"name":"Vascular Medical GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Contemporary data on the impact of high-grade atrioventricular blocks (HAVB) in acute myocardial infarction (AMI) are scarce. Therefore, we investigated this in the Swiss national AMI registry (AMIS Plus) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We included all AMI patients enrolled from January 2005 to September 2024 with available ECG information. Primary outcome was in-hospital mortality; secondary outcomes included in-hospital major adverse cardiac or cerebrovascular events (MACCE) defined as cardiogenic shock, stroke, re-infarction or death. Among 50 279 AMI patients, 747 (1.5%) patients presented with HAVB and 407 (0.8%) developed HAVB during hospitalization. Patients presenting with HAVB had increased in-hospital mortality (15% vs. 4.9%; P &amp;lt; 0.001) and MACCE (17% vs. 6.0%; P &amp;lt; 0.001) compared with those without HAVB. High-grade atrioventricular blocks on admission was an independent predictor for in-hospital mortality (OR 1.89; 95% CI, 1.42\u20132.49; P &amp;lt; 0.001), with a stronger impact on mortality in the setting of anterior compared to non-anterior AMI (OR 3.69; 95% CI, 1.99\u20136.81; pinteraction = 0.02). Independent predictors for HAVB on admission included STEMI and female sex. Rates of permanent pacemaker implantation during hospitalization in patients with HAVB on admission were higher in NSTEMI than STEMI patients (20% vs. 4.4%; P &amp;lt; 0.001). High-grade atrioventricular blocks occurring during hospital stay was associated with higher mortality (20% vs. 15%; P = 0.031) and higher permanent pacemaker rate (25% vs. 8%; P &amp;lt; 0.001) than HAVB on admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High-grade atrioventricular blocks in AMI was associated with high in-hospital mortality, especially in anterior AMI or if occurring during hospitalization. Permanent pacemaker implantation was more frequent in the setting of NSTEMI and among patients developing HAVB during hospital stay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf123","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:51:05Z","timestamp":1758196265000},"page":"42-51","source":"Crossref","is-referenced-by-count":2,"title":["Impact of high-grade atrioventricular block on outcomes in patients with acute myocardial infarction"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0956-0500","authenticated-orcid":false,"given":"Nicola","family":"Olivito","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Lugano , Via G. Buffi 13, Lugano 6900 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-5838","authenticated-orcid":false,"given":"Fabienne","family":"Foster Witassek","sequence":"additional","affiliation":[{"name":"UZH \u2013 Epidemiology, Biostatistics and Prevention Institute, AMIS Plus Data Center , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4070-6513","authenticated-orcid":false,"given":"Hans","family":"Rickli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, HOCH Health Ostschweiz , St. Gallen ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-0170","authenticated-orcid":false,"given":"Marco","family":"Roffi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University Hospitals of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-6272","authenticated-orcid":false,"given":"Dragana","family":"Radovanovic","sequence":"additional","affiliation":[{"name":"UZH \u2013 Epidemiology, Biostatistics and Prevention Institute, AMIS Plus Data Center , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-3985","authenticated-orcid":false,"given":"Giovanni","family":"Pedrazzini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Lugano , Via G. Buffi 13, Lugano 6900 ,","place":["Switzerland"]},{"name":"Division of Cardiology, Istituto Cardiocentro Ticino , Lugano ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"2026031014320012100_zuaf123-B1","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1111\/j.1540-8159.1998.tb00042.x","article-title":"Atrioventricular and intraventricular conduction disorders in acute myocardial infarction: a reappraisal in the thrombolytic era","volume":"21","author":"Simons","year":"1998","journal-title":"PACE Pacing Clin Electrophysiol"},{"key":"2026031014320012100_zuaf123-B2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jelectrocard.2021.08.002","article-title":"High-grade atrioventricular block in acute coronary syndrome: portuguese experience","volume":"68","author":"Santos","year":"2021","journal-title":"J Electrocardiol"},{"key":"2026031014320012100_zuaf123-B3","doi-asserted-by":"crossref","first-page":"1217525","DOI":"10.3389\/fcvm.2023.1217525","article-title":"Sex differences in ventricular arrhythmia, atrial fibrillation and atrioventricular block complicating acute myocardial infarction","volume":"10","author":"Alnsasra","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2026031014320012100_zuaf123-B4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jelectrocard.2018.03.003","article-title":"High-grade atrioventricular block in patients with acute myocardial infarction. 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