{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:28:44Z","timestamp":1773239324414,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union 7th Framework Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"German Heart Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010578","name":"German Cardiac Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010578","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Mild induced hypothermia (MIH) is often applied in patients with cardiac arrest (CA), but its impact on patients with infarct-related cardiogenic shock (CS) and CA remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the characteristics and outcomes of patients with infarct-related CS and CA who received MIH vs. those who did not in the randomized CULPRIT-SHOCK trial and the accompanying registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We included patients with CS and CA from the CULPRIT-SHOCK trial and registry. The primary endpoint was 1-year mortality. Secondary endpoints included death or renal replacement therapy within 30 days. A multivariate regression analysis was performed for 1-year mortality, adjusted for relevant baseline parameters. Among 550 patients with CA, 288 (52.4%) received MIH. Patients treated with MIH were younger (64 vs. 67 years, P = 0.03), had higher rates of mechanical ventilation (94.5% vs. 78.8%, P &amp;lt; 0.01), and higher mean arterial pressure (82 vs. 76\u2005mmHg, P = 0.002). The unadjusted hazard ratio (HR) for 1-year mortality favoured MIH [HR: 0.77, 95% confidence interval (CI): 0.61\u20130.97, P = 0.024]; however, after multivariate adjustment, this effect was not statistically significant (HR: 0.83, 95% CI: 0.64\u20131.09, P = 0.18). MIH was associated with a higher need for renal replacement therapy (15.2% vs. 7.5%, P = 0.005) and less use of mechanical circulatory support (21.2% vs. 34.2%, P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this retrospective analysis MIH was not significantly associated with lower 1-year mortality in patients with infarct-related CS and CA. Because of the numerically lower mortality rate, further research is necessary to clarify the role of MIH in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT01927549<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf124","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T11:27:35Z","timestamp":1758540455000},"page":"15-23","source":"Crossref","is-referenced-by-count":0,"title":["Mild induced hypothermia in patients with infarct-related cardiogenic shock and cardiac arrest: insights from the CULPRIT-SHOCK trial"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0429-8874","authenticated-orcid":false,"given":"Daniel","family":"Zeymer-von Metnitz","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital T\u00fcbingen , T\u00fcbingen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-4408","authenticated-orcid":false,"given":"Taoufik","family":"Ouarrak","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung , Ludwigshafen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-3378","authenticated-orcid":false,"given":"Kurt","family":"Huber","sequence":"additional","affiliation":[{"name":"Austrian Heart Foundation and Luwig Boltzmann Institute for Cardiovascular Research , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-4306","authenticated-orcid":false,"given":"Marko","family":"Noc","sequence":"additional","affiliation":[{"name":"Center for Intensive Internal Medicine, University Medical Center Ljubljana , Ljubljana ,","place":["Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1349-9969","authenticated-orcid":false,"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at Leipzig University , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-6238","authenticated-orcid":false,"given":"Anne","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at Leipzig University , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-283X","authenticated-orcid":false,"given":"Uwe","family":"Zeymer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung , Ludwigshafen ,","place":["Germany"]},{"name":"Department of Cardiology, University Heart Center Freiburg , Bad Krozingen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-998X","authenticated-orcid":false,"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at Leipzig University , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2177-3085","authenticated-orcid":false,"given":"Janine","family":"P\u00f6ss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at Leipzig University , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 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Experiences from Sweden in an 18-year perspective","volume":"97","author":"Adielsson","year":"2011","journal-title":"Heart"},{"key":"2026031014315593400_zuaf124-B21","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1161\/01.CIR.0000147236.85306.15","article-title":"Cardiac arrest and cardiopulmonary resuscitation outcome reports","volume":"110","author":"Jacobs","year":"2004","journal-title":"Circulation"},{"key":"2026031014315593400_zuaf124-B22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13054-022-04231-6","article-title":"Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial","volume":"26","author":"Simpson","year":"2022","journal-title":"Crit Care"},{"key":"2026031014315593400_zuaf124-B23","doi-asserted-by":"crossref","first-page":"e026539","DOI":"10.1161\/JAHA.122.026539","article-title":"Targeted temperature management in postresuscitation care after incorporating results of the TTM2 trial","volume":"11","author":"L\u00fcsebrink","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2026031014315593400_zuaf124-B24","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.resuscitation.2011.11.019","article-title":"The beneficial effect of mild therapeutic hypothermia depends on the time of complete circulatory standstill in patients with cardiac arrest","volume":"83","author":"Testori","year":"2012","journal-title":"Resuscitation"},{"key":"2026031014315593400_zuaf124-B25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/jama.2021.24776","article-title":"Effect of moderate hypothermia vs normothermia on 30-day mortality in patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenation: a randomized clinical trial","volume":"327","author":"Levy","year":"2022","journal-title":"JAMA"}],"container-title":["European Heart Journal: Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article-pdf\/doi\/10.1093\/ehjacc\/zuaf124\/64356325\/zuaf124.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/15\/1\/15\/64356325\/zuaf124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/15\/1\/15\/64356325\/zuaf124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:32:07Z","timestamp":1773167527000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/15\/1\/15\/8262575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,9,23]]},"published-print":{"date-parts":[[2026,3,10]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuaf124","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,9,23]]}}}