{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:00:53Z","timestamp":1788044453242,"version":"build-2784847793"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015086","name":"AMOMED\/AOP Orphan Pharmaceuticals GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Landiolol is an ultrashort-acting, highly cardio-selective beta1-adrenergic receptor blocker used for short-term control of tachyarrhythmias. While its real-world use has been described in Japan, data from European clinical practice are lacking. This study aimed to collect real-world data on landiolol use, effectiveness, and safety across diverse clinical settings in Europe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This multicentre, observational study included adult patients with supraventricular arrhythmias treated with landiolol. Patient characteristics, drug utilization patterns, efficacy, and safety were assessed. In total, 450 patients were enrolled and 449 were analysed (median age: 72 years, IQR 63\u201378) from 17 sites across 8 European countries. Most patients (73.1%) received landiolol for atrial fibrillation. The median (IQR) duration of infusion was 8.9 (2.3\u201334.0) h, with starting, minimum, and maximum doses of 5.3 (2.5\u201310.0), 4.0 (1.7\u201310), and 10.0 (6.0\u201330.0) \u00b5g\/kg\/min, respectively. Heart rate (HR) control, defined as HR \u2264110 b.p.m. or a reduction of &amp;gt;20% from baseline, was achieved in 74.2% of patients within 4\u2005h after treatment discontinuation, with 36.9% of arrhythmia patients restoring sinus rhythm. Blood pressure (BP) remained stable throughout treatment. A total of 123 adverse events and 113 major adverse cardiac events were reported, none of which were related to landiolol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In European clinical practice, landiolol dosing adhered to product information recommendations. Landiolol was effective in controlling HR, with minimal impact on BP. The treatment was well tolerated, and no new safety signals were identified. These findings support the efficacy and safety of landiolol across diverse clinical settings in Europe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf129","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T12:04:28Z","timestamp":1759406668000},"page":"95-103","source":"Crossref","is-referenced-by-count":0,"title":["A multicentre observational study on landiolol use, efficacy, and safety in European patients with supraventricular arrhythmia (Landi-UP)"],"prefix":"10.1093","volume":"15","author":[{"given":"Al-Medina","family":"Dizdarevic","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medical University of Vienna , W\u00e4hringer G\u00fcrtel 18-20, Vienna 1090 ,","place":["Austria"]},{"name":"Department of Clinical Pharmacology, Medical University of Vienna , W\u00e4hringer G\u00fcrtel 18-20, Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"\u0160ramko","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institute for Clinical and Experimental Medicine , V\u00edde\u0148sk\u00e1 1958\/9, Prague 140 21 ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-7923","authenticated-orcid":false,"given":"Norman","family":"Mangner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universit\u00e4t Dresden , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University , V\u00e1rosmajor Str. 68, Budapest H-1122 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-6009","authenticated-orcid":false,"given":"Endre","family":"Zima","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University , V\u00e1rosmajor Str. 68, Budapest H-1122 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaou","family":"Nikolaos","sequence":"additional","affiliation":[{"name":"Cardiology Department, Konstantopouleio-Patision General Hospital , 3-5 Agias Olgas Street, Nea Ionia 142 33, Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-5493","authenticated-orcid":false,"given":"Daniel","family":"Scherr","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Medical University of Graz , Auenbruggerplatz 15, Graz 8036 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Knotzer","sequence":"additional","affiliation":[{"name":"Klinikum Wels-Grieskirchen GmbH, Institut f\u00fcr An\u00e4sthesiologie und Intensivmedizin , Grieskirchner Stra\u00dfe 42, Wels 4600 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"K\u00f6glberger","sequence":"additional","affiliation":[{"name":"Klinikum Wels-Grieskirchen GmbH, Institut f\u00fcr An\u00e4sthesiologie und Intensivmedizin , Grieskirchner Stra\u00dfe 42, Wels 4600 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoi","family":"Nouvaki","sequence":"additional","affiliation":[{"name":"General Hospital of Nikaia, Intensive Care Unit , St. Mantouvalou 3, 18454, Nikaia, Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8895-8488","authenticated-orcid":false,"given":"Martin","family":"Martinek","sequence":"additional","affiliation":[{"name":"Ordensklinikum Linz GmbH, Elisabethinen , Fadingerstra\u00dfe 1, Linz 4020 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Hnat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 2nd Faculty of Medicine, Charles University and University Hospital Motol , V \u00davalu 84\/1, Prague 15006 ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Bethlehem","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Department of Clinical Pharmacy & Pharmacology, Medical Centre Leeuwarden , Henri Dunantweg 2, Leeuwarden 8934 AD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatko","family":"Fras","sequence":"additional","affiliation":[{"name":"Internal Clinic, University Medical Centre Ljubljana , Zalo\u0161ka 2, Ljubljana SI-1000 ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Go\u017adzik","sequence":"additional","affiliation":[{"name":"Clinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University , Borowska St. 213, Wroclaw 50-556 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Kotanidou","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Intensive Care Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School , 45-47 Ipsilandou Street, Athens 106 75 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"D\u0105browski","sequence":"additional","affiliation":[{"name":"First Department of Anaesthesiology and Intensive Care, Medical University of Lublin, ul. Jaczewskiego 8, 20-090 Lublin ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-5016","authenticated-orcid":false,"given":"Maciej","family":"Lesiak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Poznan University of Medical Sciences , Dluga 1\/2, Poznan 61-848 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Stefanska-Wronka","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Szpital Wojew\u00f3dzki w Poznaniu , \u2018ul. Jurasz\u00f3w 7\/19, Pozna\u0144 60-647 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-8618","authenticated-orcid":false,"given":"Martin","family":"Unger","sequence":"additional","affiliation":[{"name":"AOP Orphan Pharmaceuticals GmbH , Leopold-Ungar-Platz 2, Vienna 1190 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9832-6526","authenticated-orcid":false,"given":"Jan","family":"Sus","sequence":"additional","affiliation":[{"name":"AOP Orphan Pharmaceuticals GmbH , Leopold-Ungar-Platz 2, Vienna 1190 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klade","sequence":"additional","affiliation":[{"name":"AOP Orphan Pharmaceuticals GmbH , Leopold-Ungar-Platz 2, Vienna 1190 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Krejcy","sequence":"additional","affiliation":[{"name":"AOP Orphan Pharmaceuticals GmbH , Leopold-Ungar-Platz 2, Vienna 1190 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bouvet","sequence":"additional","affiliation":[{"name":"AOP Orphan Pharmaceuticals GmbH , Leopold-Ungar-Platz 2, Vienna 1190 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Oravec","sequence":"additional","affiliation":[{"name":"AOP Orphan Pharmaceuticals GmbH , Leopold-Ungar-Platz 2, Vienna 1190 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Krumpl","sequence":"additional","affiliation":[{"name":"AOP Health International Management AG , Industriering 20, Ruggell 9491 ,","place":["Liechtenstein"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Siller-Matula","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Vienna , W\u00e4hringer G\u00fcrtel 18-20, Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"2026031607515094300_zuaf129-B1","year":"2022"},{"key":"2026031607515094300_zuaf129-B2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s40265-013-0077-4","article-title":"Landiolol: a review of its use in intraoperative and postoperative tachyarrhythmias","volume":"73","author":"Plosker","year":"2013","journal-title":"Drugs"},{"key":"2026031607515094300_zuaf129-B3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40265-018-0883-9","article-title":"Landiolol: a review in tachyarrhythmias","volume":"78","author":"Syed","year":"2018","journal-title":"Drugs"},{"key":"2026031607515094300_zuaf129-B4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jjcc.2019.05.012","article-title":"A prospective observational survey on landiolol in atrial fibrillation\/atrial flutter patients with chronic heart failure \u2013 AF-CHF landiolol survey","volume":"74","author":"Yamashita","year":"2019","journal-title":"J Cardiol"},{"key":"2026031607515094300_zuaf129-B5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"2026031607515094300_zuaf129-B6","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJMoa1001337","article-title":"Lenient versus strict rate control in patients with atrial fibrillation","volume":"362","author":"Van Gelder","year":"2010","journal-title":"N Engl J Med"},{"key":"2026031607515094300_zuaf129-B7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S2213-2600(20)30037-0","article-title":"Efficacy and safety of landiolol, an ultra-short-acting beta1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-land 3S): a multicentre, open-label, randomised controlled trial","volume":"8","author":"Kakihana","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2026031607515094300_zuaf129-B8","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1001\/jama.2023.20134","article-title":"Landiolol and organ failure in patients with septic shock: the STRESS-L randomized clinical trial","volume":"330","author":"Whitehouse","year":"2023","journal-title":"JAMA"},{"key":"2026031607515094300_zuaf129-B9","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1007\/s00134-024-07587-1","article-title":"Landiolol for heart rate control in patients with septic shock and persistent tachycardia. A multicenter randomized clinical trial (Landi-SEP)","volume":"50","author":"Rehberg","year":"2024","journal-title":"Intensive Care Med"},{"key":"2026031607515094300_zuaf129-B10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1253\/circj.CJ-11-0947","article-title":"Randomized study on the efficacy and safety of landiolol, an ultra-short-acting beta1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention","volume":"76","author":"Hanada","year":"2012","journal-title":"Circ J"},{"key":"2026031607515094300_zuaf129-B11","first-page":"289","article-title":"Efficacy and safety of early intravenous landiolol on myocardial salvage in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary intervention: a randomized study","volume":"75","author":"Miyamoto","year":"2021","journal-title":"Acta Med Okayama"},{"key":"2026031607515094300_zuaf129-B12","doi-asserted-by":"crossref","first-page":"D11","DOI":"10.1093\/eurheartjsupp\/suac023","article-title":"Benefits and safety of landiolol for rapid rate control in patients with atrial tachyarrhythmias and acute decompensated heart failure","volume":"24","author":"Shiga","year":"2022","journal-title":"Eur Heart J Suppl"},{"key":"2026031607515094300_zuaf129-B13","first-page":"10265","article-title":"Efficacy and safety of landiolol for prevention of atrial fibrillation after cardiac surgery: a meta-analysis of randomized controlled trials","volume":"8","author":"Li","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"2026031607515094300_zuaf129-B14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s12325-014-0116-x","article-title":"Perioperative landiolol administration reduces atrial fibrillation after cardiac surgery: a meta-analysis of randomized controlled trials","volume":"31","author":"Sakamoto","year":"2014","journal-title":"Adv Ther"},{"key":"2026031607515094300_zuaf129-B15","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1253\/circj.CJ-12-1618","article-title":"Urgent management of rapid heart rate in patients with atrial fibrillation\/flutter and left ventricular dysfunction: comparison of the ultra-short-acting beta1-selective blocker landiolol with digoxin (J-land study)","volume":"77","author":"Nagai","year":"2013","journal-title":"Circ J"},{"key":"2026031607515094300_zuaf129-B16","first-page":"31","article-title":"Do the efficacy and safety of treatment with landiolol, an ultra-short-acting \u03b21-selective blocker, differ in the urgent management of rapid atrial fibrillation between patients complicated with cardiac versus non-cardiac disease?","volume":"68","author":"Kamijo","year":"2020","journal-title":"Shinshu Med J"},{"key":"2026031607515094300_zuaf129-B17","first-page":"671","article-title":"Clinical evaluation and prospects of landiolol in an intensive care unit ICU & CCU","volume":"36","author":"Sasaki","year":"2012","journal-title":"Jpn J Intensive Care Med"},{"key":"2026031607515094300_zuaf129-B18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00540-007-0573-3","article-title":"Clinical role and efficacy of landiolol in the intensive care unit","volume":"22","author":"Yoshida","year":"2008","journal-title":"J Anesth"},{"key":"2026031607515094300_zuaf129-B19","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1093\/eurheartjsupp\/suac025","article-title":"Short acting intravenous beta-blocker as a first line of treatment for atrial fibrillation after cardiac surgery: a prospective observational study","volume":"24","author":"Chapalain","year":"2022","journal-title":"Eur Heart J Suppl"},{"key":"2026031607515094300_zuaf129-B20","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.3390\/jcm13102951","article-title":"Landiolol for treatment of new-onset atrial fibrillation in critical care: a systematic review","volume":"13","author":"Levy","year":"2024","journal-title":"J Clin Med"},{"key":"2026031607515094300_zuaf129-B21","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3390\/jcm13061683","article-title":"Intravenous landiolol for rate control in supraventricular tachyarrhythmias in patients with left ventricular dysfunction: a systematic review and meta-analysis","volume":"13","author":"Nasoufidou","year":"2024","journal-title":"J Clin Med"},{"key":"2026031607515094300_zuaf129-B22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00228-016-2176-0","article-title":"Bolus application of landiolol and esmolol: comparison of the pharmacokinetic and pharmacodynamic profiles in a healthy Caucasian group","volume":"73","author":"Krumpl","year":"2017","journal-title":"Eur J Clin Pharmacol"},{"key":"2026031607515094300_zuaf129-B23","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal: Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article-pdf\/doi\/10.1093\/ehjacc\/zuaf129\/64521890\/zuaf129.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/15\/2\/95\/64521890\/zuaf129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/15\/2\/95\/64521890\/zuaf129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:52:04Z","timestamp":1773661924000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/15\/2\/95\/8276109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,10,6]]},"published-print":{"date-parts":[[2026,3,16]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuaf129","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2025,10,6]]}}}