{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:23:26Z","timestamp":1779254606655,"version":"3.51.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 HL007227"],"award-info":[{"award-number":["T32 HL007227"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While the aging cardiac intensive care unit (CICU) population has been well studied, young adults represent a distinct and underexplored subgroup. We aimed to characterize the demographics, clinical presentations, resource utilization, and outcomes of young adults admitted to contemporary CICUs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed consecutive adult CICU admissions from 2018 to 2023 within the Critical Care Cardiology Trials Network, a multicentre registry of advanced CICUs in North America. Patients aged 18\u201339 years were classified as \u2018young adults\u2019 and compared with those aged \u226540 years. Among 29 035 CICU admissions, 6.7% (n = 1959) were aged 18\u201339 years. Young adults were more likely to be female (40.0% vs. 36.4%, P = 0.001) and non-White (55.3% vs. 43.0%, P &amp;lt; 0.001), with fewer traditional cardiovascular risk factors. Heart failure was the leading admission diagnosis among young adults (26.4% vs. 19.5%, P &amp;lt; 0.001). Compared with older adults, young patients were more likely to present with cardiogenic shock (22.4% vs. 18.7%, P &amp;lt; 0.001) and cardiac arrest (12.7% vs. 10.6%, P = 0.003). Utilization of critical care therapies was higher, including mechanical circulatory support (13.1% vs. 11.4%, P = 0.02), with extracorporeal membrane oxygenation comprising a greater share (29.3% vs. 9.9%, P &amp;lt; 0.001). Young admissions had longer CICU stays [2.7 (1.2\u20135.8) vs. 2.2 (1.1\u20134.6) days, P &amp;lt; 0.001]. CICU mortality (6.5% vs. 10.5%, P &amp;lt; 0.001) and hospital mortality (9.5% vs. 14.4%, P &amp;lt; 0.001) were significantly lower in the young.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Young adults admitted to the CICU represent a clinically distinct population, with higher rates of high-acuity presentations and intensive resource use yet lower short-term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf161","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:08:45Z","timestamp":1765285725000},"page":"403-407","source":"Crossref","is-referenced-by-count":0,"title":["Young adults in the cardiac intensive care unit: insights from the Critical Care Cardiology Trials Network registry"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-8113","authenticated-orcid":false,"given":"Ameesh","family":"Isath","sequence":"first","affiliation":[{"name":"Center for Advanced Heart Disease, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College , 100 Woods Road, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uzair","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College , 100 Woods Road, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D","family":"Berg","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin A","family":"Bohula","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunit-Preet","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Vincent Heart Center , Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori B","family":"Daniels","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of California San Diego and UC San Diego Health System , La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins University School of Medicine , Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4050-1518","authenticated-orcid":false,"given":"Christopher B","family":"Fordyce","sequence":"additional","affiliation":[{"name":"University of British Columbia, University of British Columbia Centre for Cardiovascular Innovation, Cardiovascular Health Program, University of British Columbia Centre for Health Evaluation and Outcomes Sciences , Vancouver, BC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Jewish General Hospital, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C","family":"Kontos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Virginia Commonwealth University , Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-0182","authenticated-orcid":false,"given":"Shuangbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Max Rady College of Medicine, St. Boniface Hospital , Winnipeg, MB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Health Network and University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-2677","authenticated-orcid":false,"given":"Venu","family":"Menon","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Cleveland Clinic Foundation , OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharth M","family":"Patel","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert O","family":"Roswell","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park, Cardiovascular Institute , New York, NY, USA"},{"name":"Lenox Hospital, Northwell Health , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Morrow","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard A","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College , 100 Woods Road, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"2026051912360976100_zuaf161-B1","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1007\/s00134-007-0621-3","article-title":"Should elderly patients be admitted to the intensive care unit?","volume":"33","author":"Boumendil","year":"2007","journal-title":"Intensive Care Med"},{"key":"2026051912360976100_zuaf161-B2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1001\/jamacardio.2019.2467","article-title":"Demographics, care patterns, and outcomes of patients admitted to cardiac intensive care units: the Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness","volume":"4","author":"Bohula","year":"2019","journal-title":"JAMA Cardiol"},{"key":"2026051912360976100_zuaf161-B3","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2013.05.072","article-title":"Clinical characteristics and outcomes of young and very young adults with heart failure","volume":"62","author":"Wong","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026051912360976100_zuaf161-B4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cardfail.2024.07.001","article-title":"HF STATS 2024: heart failure epidemiology and outcomes statistics an updated 2024 report from the Heart Failure Society of America","volume":"31","author":"Bozkurt","year":"2025","journal-title":"J Card Fail"},{"key":"2026051912360976100_zuaf161-B5","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.jacc.2011.07.028","article-title":"The end of the risk-treatment paradox? A rising tide lifts all boats","volume":"58","author":"McAlister","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026051912360976100_zuaf161-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CCM.0000000000005269","article-title":"Racial disparities in ICU outcomes: a systematic review","volume":"50","author":"McGowan","year":"2022","journal-title":"Crit Care Med"},{"key":"2026051912360976100_zuaf161-B7","doi-asserted-by":"crossref","first-page":"e010614","DOI":"10.1161\/CIRCOUTCOMES.123.010614","article-title":"Sex differences in characteristics, resource utilization, and outcomes of cardiogenic shock: data from the Critical Care Cardiology Trials Network (CCCTN) registry","volume":"17","author":"Daniels","year":"2024","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2026051912360976100_zuaf161-B8","doi-asserted-by":"crossref","first-page":"e687","DOI":"10.1161\/CIR.0000000000001300","article-title":"Evolution of critical care cardiology: an update on structure, care delivery, training, and research paradigms: a scientific statement from the American Heart Association","volume":"151","author":"Sinha","year":"2025","journal-title":"Circulation"},{"key":"2026051912360976100_zuaf161-B9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMra2104669","article-title":"Outcomes after critical illness","volume":"388","author":"Herridge","year":"2023","journal-title":"N Engl J Med"}],"container-title":["European Heart Journal: Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article-pdf\/doi\/10.1093\/ehjacc\/zuaf161\/66032414\/zuaf161.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/15\/5\/403\/66032414\/zuaf161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/15\/5\/403\/66032414\/zuaf161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:36:12Z","timestamp":1779208572000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/15\/5\/403\/8384129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,12,19]]},"published-print":{"date-parts":[[2026,5,19]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuaf161","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,12,19]]}}}