{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:04:34Z","timestamp":1790762674384,"version":"4.1.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mortality in severe forms of cardiogenic shock remains above 50%, despite substantial advances in mechanical circulatory support strategies that have enabled clinicians to manage levels of patient complexity once thought unattainable. A key obstacle to effectively implementing and individualizing these sophisticated treatments lies in the continued reliance on outdated safety monitoring strategies that apply uniform cut-off values to a limited set of clinical variables. Such approaches fail to account for the dynamic and patient-specific nature of \u2018safe\u2019 haemodynamics. To overcome this, we propose an aviation-inspired safety framework, referred to by \u2018the haemodynamic envelope\u2019, designed to continuously and automatically compute patient- and time-specific thresholds across nine interrelated dimensions. This framework defines a dynamic safety window analogous to the systems that transformed flight safety.<\/jats:p>","DOI":"10.1093\/ehjacc\/zuag031","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:45:38Z","timestamp":1772887538000},"page":"674-677","source":"Crossref","is-referenced-by-count":1,"title":["The haemodynamic envelope, a novel aviation-inspired safety framework for personalized monitoring in cardiogenic shock"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-1653","authenticated-orcid":false,"given":"Christiaan Lucas","family":"Meuwese","sequence":"first","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute , Erasmus MC ,","place":["the Netherlands"]},{"name":"Department of Intensive Care Adults, Erasmus Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris Anthonius","family":"Melkert","sequence":"additional","affiliation":[{"name":"Faculty of Aerospace Engineering, Delft University of Technology , Delft ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2026093005365162000_zuag031-B1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s12471-021-01552-z","article-title":"Twelve years of circulatory extracorporeal life support at the university medical centre Utrecht","volume":"29","author":"Meuwese","year":"2021","journal-title":"Neth Heart 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