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A recently developed hs-cTnT assay requires diagnostic and prognostic evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients presenting to the emergency department with suspected non-ST-elevation MI were prospectively evaluated. Discrimination was tested using the area under the curve (AUC). Diagnostic performance was assessed with previously derived cut-off concentrations and ESC 0\/1 h algorithm. Head-to-head comparisons between the new and established assays were performed. Prognostic performance of hs-cTnT for 1-year mortality and major adverse cardiac events (MACE) was analysed using adjusted Cox regression. In 1415 patients, mean age 64 years and 64.2% male, MI was diagnosed in 12.1%. The novel TnT hs Gen 6 assay demonstrated excellent discrimination with an AUC on admission of 0.87 (95% CI: 0.84, 0.90) and 0.91 (95% CI: 0.89, 0.93) after 1 h. Using a 0 h cut-off &amp;lt;8 ng\/L or &amp;lt;18 ng\/L and \u0394 0\/1 h of &amp;lt;2 ng\/L enabled rule-out in 54.3% (95% CI: 51.7%, 57.0%), with a NPV of 99.5% (95% CI: 98.7%, 99.9%); sensitivity was 97.7% (95% CI: 94.1%, 99.4%). For rule-in, a 0 h cut-off \u2265112 ng\/L or a \u0394 0\/1 h \u2265 10 ng\/L yielded a PPV of 58.5% (95% CI: 51.9%, 64.9%) and specificity of 92.2% (95% CI: 90.6%, 93.6%) with rule-in of 16.5% (95% CI: 14.6%, 18.6%). Hs-cTnT was associated with 1-year mortality [hazard ratio (HR) 1.39 (95% CI: 1.28, 1.51)] and MACE [HR 1.22 (95% CI: 1.15, 1.29)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel hs-cTnT assay demonstrates high diagnostic accuracy to rule-out or diagnose MI and offers valuable prognostic information regarding 1-year mortality and MACE.<\/jats:p>\n                    <jats:p>Trial Registration: clinicaltrials.gov (NCT02355457)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuag044","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:39:12Z","timestamp":1776253152000},"page":"535-544","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic validation of a novel high-sensitivity cardiac troponin T assay"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9373-5985","authenticated-orcid":false,"given":"Ben","family":"V\u00f6lschow","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Strau\u00df","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Arne","family":"S\u00f6rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Thie\u00dfen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Lehmacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5233-0680","authenticated-orcid":false,"given":"Bet\u00fcl","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beya","family":"Abdennadher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Dehkordi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M","family":"Haller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck , Martinistrasse 52, Hamburg 20246 ,","place":["Germany"]},{"name":"Department for Internal Medicine II, Division of Cardiology, Medical University of Vienna , W\u00e4hringer G\u00fcrtel 18-20, 1090 Vienna 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Laboratory Medicine, University Medicine Greifswald , Ferdinand-Sauerbruch-Stra\u00dfe, Greifswald 17489 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Gau\u00df","sequence":"additional","affiliation":[{"name":"University Institute of Clinical Chemistry and Laboratory Medicine, University Oldenburg , Rahel-Straus-Stra\u00dfe 10, Oldenburg 26133 ,","place":["Germany"]},{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald , Ferdinand-Sauerbruch-Stra\u00dfe, Greifswald 17489 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-6542","authenticated-orcid":false,"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistrasse 52, Hamburg 20246 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