{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:46:24Z","timestamp":1793317584035,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Systemic inflammation in cardiogenic shock is associated with increased disease severity and mortality. C-reactive protein (CRP) is a widely accessible inflammatory biomarker that may aid phenotyping and risk stratification. We evaluated the association between admission CRP and in-hospital mortality in patients with cardiogenic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using a multicentre, nationally representative database, we identified adults with a discharge diagnosis of cardiogenic shock from 2015 to 2023 who had CRP measured within 2 days of hospital admission; patients with sepsis were excluded. C-reactive protein was analysed in tertiles. Inverse probability weighting (IPW) was used to assess associations with in-hospital mortality. Secondary outcomes included intensive care unit (ICU) and hospital length of stay and total cost. We identified 26 525 patients; median (interquartile ranges) CRP was 18.4 mg\/L (5.0\u201367.0 mg\/L). The in-hospital mortality was 28.7, 32.7, and 42.3% across tertiles 1\u20133. In-hospital mortality increased by 19% for each 50-unit increase in CRP [odds ratio (OR) 1.19; 95% confidence interval (CI): 1.16\u20131.21, P &amp;lt; 0.001). After IPW, tertiles 2 and 3 had higher absolute mortality risks compared with tertile 1 by 3.9% (95% CI: 2.4\u20135.3%) and 12.4% (95% CI: 10.9\u201313.9%), respectively (both, P &amp;lt; 0.001). Findings were consistent in sensitivity analyses restricted to Day 1 CRP measurement, primary diagnoses of heart failure or myocardial infarction, and among patients requiring early mechanical circulatory support (all, P &amp;lt; 0.05). The median ICU and hospital stay increased significantly across tertiles (all, P &amp;lt; 0.001); total cost was not statistically different.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with cardiogenic shock, a readily available biomarker, elevated CRP was associated with higher in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuag083","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:16:25Z","timestamp":1781507785000},"page":"728-738","source":"Crossref","is-referenced-by-count":0,"title":["Associations between admission C-reactive protein and in-hospital mortality amongst patients with cardiogenic shock"],"prefix":"10.1093","volume":"15","author":[{"given":"Sierra","family":"Mendelsohn","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , 789 Howard Avenue, New Haven, CT 06517 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-6430","authenticated-orcid":false,"given":"Israel","family":"Safiriyu","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , 789 Howard Avenue, New Haven, CT 06517 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Schwann","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , 789 Howard Avenue, New Haven, CT 06517 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"El Charif","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , 789 Howard Avenue, New Haven, CT 06517 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5014-8139","authenticated-orcid":false,"given":"Jessica","family":"Mirabile","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , 789 Howard Avenue, New Haven, CT 06517 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-0557","authenticated-orcid":false,"given":"Mark","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , 789 Howard Avenue, New Haven, CT 06517 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Ali","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , 789 Howard Avenue, New Haven, CT 06517 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Notarianni","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Cardiothoracic Division, Yale School of Medicine , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7659-6135","authenticated-orcid":false,"given":"Balimkiz","family":"Senman","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center and Albert Einstein College of Medicine , Bronx, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason N","family":"Katz","sequence":"additional","affiliation":[{"name":"Leon H Charney Division of Cardiology, NewYork University Grossman School of Medicine , New York, NY 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