{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:36:36Z","timestamp":1761060996721},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>Cardiac resynchronization therapy (CRT) is a disease-modifying therapy in patients with chronic heart failure (CHF). Current guidelines ascribe CRT eligibility on three parameters only: left ventricular ejection fraction (LVEF), QRS duration, and New York Heart Association (NYHA) functional class. However, one-third of CHF patients does not benefit from CRT. This study evaluated whether 123I-meta-iodobenzylguanidine (123I-mIBG) assessed cardiac sympathetic activity could optimize CRT patient selection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>A total of 78 stable CHF subjects (age 66.8\u2009\u00b1\u20099.6\u2009years, 73% male, LVEF 25.2\u2009\u00b1\u20096.7%, QRS duration 153\u2009\u00b1\u200923\u2009ms, NYHA 2.2\u2009\u00b1\u20090.7) referred for CRT implantation were enrolled. Subjects underwent 123I-mIBG scintigraphy prior to implantation. Early and late heart-to-mediastinum (H\/M) ratio and 123I-mIBG washout were calculated. CRT response was defined as either an increase of LVEF to &amp;gt;35%, any improvement in LVEF of &amp;gt;10%, QRS shortening to &amp;lt;150\u2009ms, or improvement in NYHA class of &amp;gt;1 class. In 33 patients LVEF increased to &amp;gt;35%, QRS decreased &amp;lt;150\u2009ms in 36 patients, and NYHA class decreased in 33 patients. Late H\/M ratio and hypertension were independent predictors of LVEF improvement to &amp;gt;35% (P\u2009=\u20090.0014 and P\u2009=\u20090.0149, respectively). In addition, early H\/M ratio, LVEF, and absence of diabetes mellitus (DM) were independent predictors for LVEF improvement by &amp;gt;10%. No independent predictors were found for QRS shortening to &amp;lt;150\u2009ms or improvement in NYHA class.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion\u2003<\/jats:title>\n                  <jats:p>Early and late H\/M ratio were independent predictors of CRT response when improvement of LVEF was used as measure of response. Therefore, cardiac 123I-mIBG scintigraphy may be used as a tool to optimize selection of subjects that might benefit from CRT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa045","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T12:20:22Z","timestamp":1583497222000},"page":"49-57","source":"Crossref","is-referenced-by-count":9,"title":["The relation between cardiac 123I-<i>m<\/i>IBG scintigraphy and functional response 1 year after CRT implantation"],"prefix":"10.1093","volume":"22","author":[{"given":"D O","family":"Verschure","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands"},{"name":"Department of Cardiology, Zaans Medical Center, Koningin Julianaplein 58, 1502 DV Zaandam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Poel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"De Vincentis","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Anatomo-Pathology, \"Sapienza\" University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Frantellizzi","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Anatomo-Pathology, \"Sapienza\" University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Functional Imaging and Artificial Intelligence, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Gheysens","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc, Hippokrateslaan 10, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"de Groot","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Cardiology, Amsterdam University Medical Centers, Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Verberne","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"2020122315195097800_jeaa045-B1","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2020122315195097800_jeaa045-B2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0167-5273(02)00270-X","article-title":"Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS 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