{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:59:37Z","timestamp":1793642377174,"version":"4.5.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-114997"],"award-info":[{"award-number":["MOP-114997"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-2455048"],"award-info":[{"award-number":["MOP-2455048"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-143225"],"award-info":[{"award-number":["FDN-143225"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of the Quebec Heart and Lung Institute"},{"name":"Fonds de Recherche Qu\u00e9bec\u2014Sant\u00e9"},{"DOI":"10.13039\/501100000156","name":"FRQS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de Recherche Qu\u00e9bec\u2014Sant\u00e9"},{"DOI":"10.13039\/501100000156","name":"FRQS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u2018Connect Talent\u2019 research chair from Region Pays de la Loire and Nantes Metropole"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the progression of aortic stenosis (AS) in patients with bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>One hundred and forty-one patients with mild-to-moderate AS, recruited prospectively in the PROGRESSA study, were included in this sub-analysis. Baseline clinical, Doppler echocardiography and multidetector computed tomography characteristics were compared between BAV (n\u2009=\u200932) and TAV (n\u2009=\u2009109) patients. The 2-year haemodynamic [i.e. peak aortic jet velocity (Vpeak) and mean transvalvular gradient (MG)] and anatomic [i.e. aortic valve calcification density (AVCd) and aortic valve calcification density ratio (AVCd ratio)] progression of AS were compared between the two valve phenotypes. The 2-year progression rate of Vpeak was: 16 (\u22120 to 40) vs. 17 (3\u201335) cm\/s, P\u2009=\u20090.95; of MG was: 1.8 (\u22120.7 to 5.8) vs. 2.6 (0.4\u20134.8) mmHg, P\u2009=\u20090.56; of AVCd was 32 (2\u2013109) vs. 52 (25\u201385) AU\/cm2, P\u2009=\u20090.15; and of AVCd ratio was: 0.08 (0.01\u20130.23) vs. 0.12 (0.06\u20130.18), P\u2009=\u20090.16 in patients with BAV vs. TAV. In univariable analyses, BAV was not associated with AS progression (all, P\u2009\u2265\u20090.26). However, with further adjustment for age, AS baseline severity, and several risk factors (i.e. sex, history of hypertension, creatinine level, diabetes, metabolic syndrome), BAV was independently associated with faster haemodynamic (Vpeak: \u03b2\u2009=\u20090.31, P\u2009=\u20090.02) and anatomic (AVCd: \u03b2\u2009=\u20090.26, P\u2009=\u20090.03 and AVCd ratio: \u03b2\u2009=\u20090.26, P\u2009=\u20090.03) progression of AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with mild-to-moderate AS, patients with BAV have faster haemodynamic and anatomic progression of AS when compared to TAV patients with similar age and risk profile. This study highlights the importance and necessity to closely monitor patients with BAV and to adequately control and treat their risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>https:\/\/clinicaltrials.gov Unique identifier: NCT01679431.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa068","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T08:09:13Z","timestamp":1585123753000},"page":"727-734","source":"Crossref","is-referenced-by-count":49,"title":["Effect of bicuspid aortic valve phenotype on progression of aortic stenosis"],"prefix":"10.1093","volume":"21","author":[{"given":"Myl\u00e8ne","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Medicine, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval\/Quebec Heart & Lung Institute-Laval University, 2725 Chemin Sainte-Foy, Quebec City, Quebec G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Tastet","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval\/Quebec Heart & Lung Institute-Laval University, 2725 Chemin Sainte-Foy, Quebec City, Quebec G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Capoulade","sequence":"additional","affiliation":[{"name":"Inserm UMR 1087\/CNRS UMR 6291, IRS-UN, L'institut du thorax, CHU Nantes, UNIV Nantes, 8 quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval\/Quebec Heart & Lung Institute-Laval University, 2725 Chemin Sainte-Foy, Quebec City, Quebec G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lisabeth","family":"B\u00e9dard","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval\/Quebec Heart & Lung Institute-Laval University, 2725 Chemin Sainte-Foy, Quebec City, Quebec G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval\/Quebec Heart & Lung Institute-Laval University, 2725 Chemin Sainte-Foy, Quebec City, Quebec G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":false,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval\/Quebec Heart & Lung Institute-Laval University, 2725 Chemin Sainte-Foy, Quebec City, Quebec G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"2020082810120864100_jeaa068-B1","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2020082810120864100_jeaa068-B2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"2020082810120864100_jeaa068-B3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0002-9149(70)90761-7","article-title":"The congenitally bicuspid aortic valve: a study of 85 autopsy cases","volume":"26","author":"Roberts","year":"1970","journal-title":"Am J Cardiol"},{"key":"2020082810120864100_jeaa068-B4","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.0000027905.26586.E8","article-title":"Clinical and pathophysiological implications of a bicuspid aortic valve","volume":"106","author":"Fedak","year":"2002","journal-title":"Circulation"},{"key":"2020082810120864100_jeaa068-B5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.CIR.23.4.485","article-title":"The congenital bicuspid aortic valve","volume":"23","author":"Edwards","year":"1961","journal-title":"Circulation"},{"key":"2020082810120864100_jeaa068-B6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0002-9149(93)90799-I","article-title":"Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves","volume":"71","author":"Beppu","year":"1993","journal-title":"Am J Cardiol"},{"key":"2020082810120864100_jeaa068-B7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/hrt.69.3.237","article-title":"Progression of aortic valve dysfunction in 51 adult patients with congenital bicuspid aortic valve: assessment and follow up by Doppler echocardiography","volume":"69","author":"Pachulski","year":"1993","journal-title":"Br Heart J"},{"key":"2020082810120864100_jeaa068-B8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ehjci\/jew013","article-title":"Systolic hypertension and progression of aortic valve calcification in patients with aortic stenosis: results from the PROGRESSA study","volume":"18","author":"Tastet","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2020082810120864100_jeaa068-B9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007980","article-title":"ApoB\/ApoA-I ratio is associated with faster hemodynamic progression of aortic stenosis: results from the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study","volume":"7","author":"Tastet","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2020082810120864100_jeaa068-B10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jacc.2012.03.052","article-title":"Impact of metabolic syndrome on progression of aortic stenosis: influence of age and statin therapy","volume":"60","author":"Capoulade","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2020082810120864100_jeaa068-B11","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jacc.2015.07.020","article-title":"Oxidized phospholipids, lipoprotein(a), and progression of calcific aortic valve stenosis","volume":"66","author":"Capoulade","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2020082810120864100_jeaa068-B12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jcmg.2014.09.016","article-title":"Impact of plasma Lp-PLA2 activity on the progression of aortic stenosis: the PROGRESSA study","volume":"8","author":"Capoulade","year":"2015","journal-title":"J Am Coll Cardiol Img"},{"key":"2020082810120864100_jeaa068-B13","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1161\/01.CIR.95.9.2262","article-title":"Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome","volume":"95","author":"Otto","year":"1997","journal-title":"Circulation"},{"key":"2020082810120864100_jeaa068-B14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1161\/01.ATV.0000255952.47980.c2","article-title":"Aortic valve calcification: determinants and progression in the population","volume":"27","author":"Messika-Zeitoun","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020082810120864100_jeaa068-B15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0002-9149(01)02241-X","article-title":"Determinants of progression of aortic stenosis in patients aged &gt;= 40 years","volume":"89","author":"Wongpraparut","year":"2002","journal-title":"Am J Cardiol"},{"key":"2020082810120864100_jeaa068-B16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ehj.2003.12.002","article-title":"Mild and moderate aortic stenosis: natural history and risk stratification by echocardiography","volume":"25","author":"Rosenhek","year":"2004","journal-title":"Eur Heart J"},{"key":"2020082810120864100_jeaa068-B17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.amjcard.2014.09.049","article-title":"Predictors and progression of aortic stenosis in patients with preserved left ventricular ejection fraction","volume":"115","author":"Ersboll","year":"2015","journal-title":"Am J Cardiol"},{"key":"2020082810120864100_jeaa068-B18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijcard.2006.11.092","article-title":"Congenital aortic stenosis in adults: rate of progression and predictors of clinical outcome","volume":"122","author":"Yap","year":"2007","journal-title":"Int J Cardiol"},{"key":"2020082810120864100_jeaa068-B19","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/heartjnl-2014-307154","article-title":"Haemodynamic and anatomic progression of aortic stenosis","volume":"101","author":"Nguyen","year":"2015","journal-title":"Heart"},{"key":"2020082810120864100_jeaa068-B20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4250\/jcu.2010.18.4.127","article-title":"Progression rate of aortic valve stenosis in Korean patients","volume":"18","author":"Ryu","year":"2010","journal-title":"J Cardiovasc Ultrasound"},{"key":"2020082810120864100_jeaa068-B21","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/CIRCULATIONAHA.109.900027","article-title":"Effect of lipid lowering with rosuvastatin on progression of aortic stenosis. Results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial","volume":"121","author":"Chan","year":"2010","journal-title":"Circulation"},{"key":"2020082810120864100_jeaa068-B22","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"2020082810120864100_jeaa068-B23","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.jacc.2013.08.1621","article-title":"The complex nature of discordant severe calcified aortic valve disease grading: new insights from combined Doppler-echocardiographic and computed tomographic study","volume":"62","author":"Clavel","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2020082810120864100_jeaa068-B24","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"2020082810120864100_jeaa068-B25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature03940","article-title":"Mutations in NOTCH1 cause aortic valve disease","volume":"437","author":"Garg","year":"2005","journal-title":"Nature"},{"key":"2020082810120864100_jeaa068-B26","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/0735-1097(90)90249-O","article-title":"Contrasting histoarchitecture of calcified leaflets from stenotic bicuspid versus stenotic tricuspid aortic valves","volume":"15","author":"Isner","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"2020082810120864100_jeaa068-B27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10237-014-0623-3","article-title":"Bicuspid aortic valves are associated with increased wall and turbulence shear stress levels compared to trileaflet aortic valves","volume":"14","author":"Saikrishnan","year":"2015","journal-title":"Biomech Model Mechanobiol"},{"key":"2020082810120864100_jeaa068-B28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/echo.12712","article-title":"The role of jet eccentricity in generating disproportionately elevated transaortic pressure gradients in patients with aortic stenosis","volume":"32","author":"Abbas","year":"2015","journal-title":"Echocardiography"},{"key":"2020082810120864100_jeaa068-B29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/heart.88.4.348","article-title":"T lymphocyte infiltration in non-rheumatic aortic stenosis: a comparative descriptive study between tricuspid and bicuspid aortic valves","volume":"88","author":"Wallby","year":"2002","journal-title":"Heart"},{"key":"2020082810120864100_jeaa068-B30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ehjci\/jex211","article-title":"Comparative study of bicuspid vs. tricuspid aortic valve stenosis","volume":"19","author":"Huntley","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/21\/7\/727\/33693217\/jeaa068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/21\/7\/727\/33693217\/jeaa068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T12:50:34Z","timestamp":1598878234000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/21\/7\/727\/5835256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,9]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,5,9]]},"published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jeaa068","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,5,9]]}}}