{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:28:41Z","timestamp":1787858921691,"version":"build-2784847793"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr Miriam and Sheldon G Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Arthur J E Child Fellowship grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>We assessed the association between early invasive therapy, burden of ischaemia, and survival benefit separately for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Ischaemia involving more than 10% of the left ventricular myocardium may identify patients who benefit from revascularization. However, it is not clear whether this association exists with both PCI and CABG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and results<\/jats:title>\n                  <jats:p>Patients who underwent single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) between 1992 and 2012 were identified. Early revascularization was defined as PCI or CABG performed within 90\u2009days of SPECT MPI. The association between early PCI or CABG and all-cause mortality was assessed using a doubly robust, propensity score matching analysis. In total, 54\u2009522 patients were identified, with median follow-up 8.0\u2009years. Early PCI was performed in 2688 patients and early CABG in 1228. In the matched cohorts, early revascularization was associated with improved survival compared to medical therapy in patients with more than 15% ischaemia for both PCI [adjusted hazard ratio (HR) 0.70, P\u2009=\u20090.002] and CABG (adjusted HR 0.73, P\u2009=\u20090.008).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion\u2003<\/jats:title>\n                  <jats:p>In this observational analysis, both PCI and CABG were associated with reduced all-cause mortality in the presence of moderate to severe ischaemia after adjusting for factors leading to revascularization. As the threshold for improved outcomes with revascularization was similar for PCI and CABG, our results suggest that decisions for PCI vs. CABG for early revascularization should be determined by coronary anatomy, patient characteristics, and shared decision making, but not by the burden of ischaemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa083","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T19:10:44Z","timestamp":1586373044000},"page":"961-970","source":"Crossref","is-referenced-by-count":44,"title":["Percutaneous or surgical revascularization is associated with survival benefit in stable coronary artery disease"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-2433","authenticated-orcid":false,"given":"Robert J H","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Cardiac Sciences, University of Calgary, 3230 Hospital Dr NW, Calgary, AB, Canada, T2N 4Z6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O","family":"Bonow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Northwestern University, Feinberg School of Medicine, Bluhm Cardiovascular Institute, Northwestern Memorial Hospital, 675 N St Clair St 19th Fl, Suite 100, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Gransar","sequence":"additional","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr J","family":"Slomka","sequence":"additional","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Tamarappoo","sequence":"additional","affiliation":[{"name":"Department of Imaging, Cedars-Sinai Medical Center, Room 1258, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Rozanski","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mount Sinai St. Luke\u2019s Hospital, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 1190 5th Ave, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Doenst","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University of Jena, F\u00fcrstengraben 1, 07743 Jena, 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