{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:43:12Z","timestamp":1774683792578,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571638"],"award-info":[{"award-number":["81571638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Incubation Project, West China Hospital, Sichuan University","award":["ZYJC18013"],"award-info":[{"award-number":["ZYJC18013"]}]},{"name":"Clinical Research Incubation Project, West China Hospital, Sichuan University","award":["Z2018A08"],"award-info":[{"award-number":["Z2018A08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To evaluate the prognostic value of left ventricular (LV) remodelling index (RI) in idiopathic dilated cardiomyopathy (DCM) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively enrolled 412 idiopathic DCM patients and 130 age- and sex-matched healthy volunteers who underwent cardiovascular magnetic resonance imaging between September 2013 and March 2018. RI was defined as the cubic root of the LV end-diastolic volume divided by the mean LV wall thickness on basal short-axis slice. The primary endpoint included all-cause mortality and heart transplantation. The secondary endpoint included the primary endpoint and heart failure (HF) readmission. During the median follow-up of 28.1\u2009months (interquartile range: 19.3\u201343.0\u2009months), 62 (15.0%) and 143 (34.7%) patients reached the primary and secondary endpoints, respectively. Stepwise multivariate Cox regression showed that RI [hazard ratio (HR) 1.20, 95% confidence interval (CI) 1.11\u20131.30, P\u2009&amp;lt;\u20090.001], late gadolinium enhancement (LGE) presence and log (N-terminal pro-B-type natriuretic peptide) were independent predictors of the primary endpoint, while RI (HR 1.15, 95% CI 1.08\u20131.23, P\u2009&amp;lt;\u20090.001) and extracellular volume were independent predictors of the secondary endpoint. The addition of RI to LV ejection fraction (EF) and LGE presence showed significantly improved global \u03c72 for predicting primary and secondary endpoints (both P\u2009&amp;lt;\u20090.001). Furthermore, RI derived from echocardiography also showed independent prognostic value for primary and secondary endpoints with clinical risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>RI is an independent predictor of all-cause mortality, heart transplantation, and HF readmission in DCM patients and provides incremental prognostic value to LVEF and LGE presence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa144","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T19:06:52Z","timestamp":1588532812000},"page":"1197-1207","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic value of left ventricular remodelling index in idiopathic dilated cardiomyopathy"],"prefix":"10.1093","volume":"22","author":[{"given":"Yuanwei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaodan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"},{"name":"Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, No.1, Dahua Road, Dongcheng District, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Ave., Shenzhen University Town, Nanshan, Shenzhen, Guangdong 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mui","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Pennsylvania, 3400 civic center boulevard, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuancheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchi","family":"Han","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Pennsylvania, 3400 civic center boulevard, Philadelphia, PA 19104, 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