{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:22Z","timestamp":1792785862404,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Nancy CHRU"},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","award":["ANR-15-RHU-0004"],"award-info":[{"award-number":["ANR-15-RHU-0004"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French PIA project \u00abLorraine Universit\u00e9 d\u2019Excellence \u00bb GEENAGE","award":["ANR-15-IDEX-04-LUE"],"award-info":[{"award-number":["ANR-15-IDEX-04-LUE"]}]},{"name":"FEDER IT2MP"},{"name":"French Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\u2003<\/jats:title>\n                    <jats:p>Mechanical alterations in patients with electrical conduction abnormalities are reported to have prognostic value in patients with left ventricular asynchrony or long QT syndrome beyond electrocardiogram (ECG) variables. Whether conduction and repolarization patterns derived from ECG are associated with speckle tracking echocardiography parameters in subjects without overt cardiac disease is yet to be investigated. To report ranges of longitudinal deformation according to conduction and repolarization values in a population-based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results\u2003<\/jats:title>\n                    <jats:p>One thousand, one hundred, and forty subjects (48.6\u2009\u00b1\u200914.0\u2009years, 47.7% men) enrolled in the fourth visit of the STANISLAS cohort (Lorraine, France) were studied. Echocardiography strain was performed in all subjects. RR, PR, QRS, and QT intervals were retrieved from digitalized 12-lead ECG. Echocardiographic data were stratified according to quartiles of QRS and QTc duration values. Full-wall global longitudinal strain (GLS) was \u221221.1 \u00b1 2.5% with a mechanical dispersion (MD) value of 34\u2009\u00b1\u200912\u2009ms. Absolute GLS value was lower in the longest QRS quartile and shortest QTc quartile (both P\u2009&amp;lt;\u20090.001). Time-to-peak of strain was not significantly different according to QRS duration although significantly higher in patients with higher QTc (P\u2009&amp;lt;\u20090.001). MD was significantly greater in patients with longer QTc (32\u2009\u00b1\u200912\u2009ms for QTc\u2009&amp;lt;\u2009396\u2009ms vs. 36\u2009\u00b1\u200912\u2009ms for QTc\u2009&amp;gt;\u2009421\u2009ms; P\u2009=\u20090.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u2003<\/jats:title>\n                    <jats:p>Longer QTc is related to increased MD and better longitudinal strain values. In a population-based setting, QRS is not associated with MD, suggesting that echocardiography-based dyssynchrony does not largely overlap with ECG-based dyssynchrony.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa148","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T15:17:15Z","timestamp":1588691835000},"page":"1237-1245","source":"Crossref","is-referenced-by-count":16,"title":["Left ventricular myocardial deformation pattern, mechanical dispersion, and their relation with electrocardiogram markers in the large population-based STANISLAS cohort: insights into electromechanical coupling"],"prefix":"10.1093","volume":"21","author":[{"given":"Mario","family":"Verdugo-Marchese","sequence":"first","affiliation":[{"name":"D\u00e9partement coeur-vaisseaux, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Coiro","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM, Centre d\u2019Investigations Cliniques Plurith\u00e9matique 1433, CHRU de Nancy, Inserm U1116, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) Network, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"Division of Cardiology, University of Perugia, Ospedale S. Maria della Misericordia, Piazzale Giorgio Menghini, 1, 06129 Perugia PG, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Selton-Suty","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Institut Lorrain du C\u0153ur et des Vaisseaux, Centre Hospitalier Universitaire de Nancy, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-2256","authenticated-orcid":false,"given":"Masatake","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM, Centre d\u2019Investigations Cliniques Plurith\u00e9matique 1433, CHRU de Nancy, Inserm U1116, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) Network, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Venner","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Institut Lorrain du C\u0153ur et des Vaisseaux, Centre Hospitalier Universitaire de Nancy, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM, Centre d\u2019Investigations Cliniques Plurith\u00e9matique 1433, CHRU de Nancy, Inserm U1116, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) Network, Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM, Centre 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