{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:57:51Z","timestamp":1793775471308,"version":"4.6.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to validate the tricuspid annular plane systolic excursion\/systolic pulmonary artery (PA) pressure (TAPSE\/PASP) ratio with the invasive pressure\u2013volume (PV) loop-derived end-systolic right ventricular (RV) elastance\/PA elastance (Ees\/Ea) ratio in patients with heart failure with reduced ejection fraction (HFREF) and secondary pulmonary hypertension (PH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The relationship of TAPSE and TAPSE\/PASP with RV-PV loop (single-beat)-derived contractility Ees, afterload Ea, and Ees\/Ea was assessed in 110 patients with HFREF with and without secondary PH. The results were compared with other surrogate parameters such as the fractional area change\/PASP ratio. The association of the surrogates with all-cause mortality was evaluated. In patients with PH (n\u2009=\u200974, 67%), TAPSE significantly correlated with Ees (r\u2009=\u20090.356), inverse with Ea (r\u2009=\u2009\u22120.514) but was most closely associated with Ees\/Ea (r\u2009=\u20090.77). Placing TAPSE in a ratio with PASP slightly reduced the relationship to Ees\/Ea (r\u2009=\u20090.71) but was more closely related to the parameters of PA vascular load, diastolic RV function, and RV energetics. The area under the curve of TAPSE\/PASP and TAPSE for discriminating overall survival in receiver operating characteristic analysis was not different (P\u2009=\u20090.78. Prognostic relevant cut-offs were 17\u2009mm for TAPSE and 0.38\u2009mm\/mmHg for TAPSE\/PASP. Both parameters in multivariate cox regression remained independently prognostically relevant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAPSE is an easily and reliably obtainable and valid surrogate parameter for RV\u2013PA coupling in PH due to HFREF. Putting TAPSE into a ratio with PASP did not further improve the coupling information or prognostic assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Identifier<\/jats:title><jats:p>DRKS\u2014German Clinical Trials Register (DRKS00011133; https:\/\/www.drks.de\/drks_web\/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00011133).<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa285","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T19:14:36Z","timestamp":1601925276000},"page":"168-176","source":"Crossref","is-referenced-by-count":98,"title":["Pressure\u2013volume loop validation of TAPSE\/PASP for right ventricular arterial coupling in heart failure with pulmonary hypertension"],"prefix":"10.1093","volume":"22","author":[{"given":"Alexander","family":"Schmeisser","sequence":"first","affiliation":[{"name":"Division of Cardiology and Angiology, Department of Internal Medicine, Magdeburg University, Leipziger Str. 44, D-39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-8539","authenticated-orcid":false,"given":"Thomas","family":"Rauwolf","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Angiology, Department of Internal Medicine, Magdeburg University, Leipziger Str. 44, D-39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Groscheck","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Angiology, Department of Internal Medicine, Magdeburg University, Leipziger Str. 44, D-39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Kropf","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Medical Informatics, Magdeburg University, D-39120 Magdeburg, 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