{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:23:21Z","timestamp":1785461001877,"version":"3.56.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","award":["GRS 1524\/A\/17"],"award-info":[{"award-number":["GRS 1524\/A\/17"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministerio de Ciencia y Universidades: Juan de la Cierva-Incorporaci\u00f3n fellowship","award":["IJCI-2014-19507"],"award-info":[{"award-number":["IJCI-2014-19507"]}]},{"name":"EU \u2013 European Regional Development Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Timing surgery in chronic aortic regurgitation (AR) relies mostly on echocardiography. However, cardiac magnetic resonance (CMR) may be more accurate for quantifying regurgitation and left ventricular (LV) remodelling. We aimed to compare the technical and clinical efficacies of echocardiography and CMR to account for the severity of the disease, the degree of LV remodelling, and predict AR-related outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We studied 263 consecutive patients with isolated AR undergoing echocardiography and CMR. After a median follow-up of 33\u2009months, 76 out of 197 initially asymptomatic patients reached the primary endpoint of AR-related events: 6 patients (3%) were admitted for heart failure, and 70 (36%) underwent surgery. Adjusted survival models based on CMR improved the predictions of the primary endpoint based on echocardiography: R2 = 0.37 vs. 0.22, \u03c72 = 97 vs. 49 (P\u2009&amp;lt;\u20090.0001), and C-index = 0.80 vs. 0.70 (P\u2009&amp;lt;\u20090.001). This resulted in a net classification index of 0.23 (0.00\u20130.46, P\u2009=\u20090.046) and an integrated discrimination improvement of 0.12 (95% confidence interval 0.08\u20130.58, P\u2009=\u20090.02). CMR-derived regurgitant fraction (&amp;lt;28, 28\u201337, or &amp;gt;37%) and LV end-diastolic volume (&amp;lt;83, 183\u2013236, or &amp;gt;236\u2009mL) adequately stratified patients with normal EF. The agreement between techniques for grading AR severity and assessing LV dilatation was poor, and CMR showed better reproducibility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CMR improves the clinical efficacy of ultrasound for predicting outcomes of patients with AR. This is due to its better reproducibility and accuracy for grading the severity of the disease and its impact on the LV. Regurgitant fraction, LV ejection fraction, and end-diastolic volume obtained by CMR most adequately predict AR-related events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa338","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T12:39:28Z","timestamp":1606307968000},"page":"392-401","source":"Crossref","is-referenced-by-count":16,"title":["A comparison of the clinical efficacy of echocardiography and magnetic resonance for chronic aortic regurgitation"],"prefix":"10.1093","volume":"23","author":[{"given":"Andrea","family":"Postigo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"P\u00e9rez-David","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Revilla","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias del Coraz\u00f3n. Hospital Cl\u00ednico Universitario de Valladolid, and CIBERCV, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladr\u00f3n Abia","family":"Raquel","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias del Coraz\u00f3n. Hospital Cl\u00ednico Universitario de Valladolid, and CIBERCV, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gonz\u00e1lez-Mansilla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Prieto-Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M \u00c1ngeles","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Ana","family":"L\u00f3pez-Jimenez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Sevilla","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias del Coraz\u00f3n. Hospital Cl\u00ednico Universitario de Valladolid, and CIBERCV, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Urue\u00f1a","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias del Coraz\u00f3n. Hospital Cl\u00ednico Universitario de Valladolid, and CIBERCV, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mart\u00ednez-Legazpi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Fern\u00e1ndez-Avil\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, and CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San Rom\u00e1n","family":"J. 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