{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:28:03Z","timestamp":1781249283968,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Ministry of Health to IRCCS Policlinico San Donato"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Fabry cardiomyopathy is characterized by glycosphingolipid storage and increased myocardial trabeculation has also been demonstrated. This study aimed to explore by cardiac magnetic resonance whether myocardial trabecular complexity, quantified by endocardial border fractal analysis, tracks phenotype evolution in Fabry cardiomyopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Study population included 20 healthy controls (12 males, age 32\u00b19) and 45 Fabry patients divided into three groups: 15 left ventricular hypertrophy (LVH)-negative patients with normal T1 (5 males, age 28\u00b113; Group 1); 15 LVH-negative patients with low T1 (9 males, age 33\u00b19.6; Group 2); 15 LVH-positive patients (11 males, age 53.5\u00b19.6; Group 3). Trabecular fractal dimensions (Dfs) (total, basal, mid-ventricular, and apical) were evaluated on cine images. Total Df was higher in all Fabry groups compared to controls, gradually increasing from controls to Group 3 (1.27\u00b10.02 controls vs. 1.29\u00b10.02 Group 1 vs. 1.30\u00b10.02 Group 2 vs. 1.34\u00b10.02 Group 3; P&amp;lt;0.001). Group 3 showed significantly higher values of all Dfs compared to the other Groups. Both basal and total Dfs were significantly higher in Group 1 compared with controls (basal: 1.30\u00b10.03 vs. 1.26\u00b10.04, P\u00a0=0.010; total: 1.29\u00b10.02 vs. 1.27\u00b10.02, P=0.044). Total Df showed significant correlations with: (i) T1 value (r=\u22120.569; P&amp;lt;0.001); (ii) LV mass (r=0.664, P&amp;lt;0.001); (iii) trabecular mass (r=0.676; P\u00a0&amp;lt;0.001); (iv) Mainz Severity Score Index (r=0.638; P&amp;lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Fabry cardiomyopathy is characterized by a progressive increase in Df of endocardial trabeculae together with shortening of T1 values. Myocardial trabeculation is increased before the presence of detectable sphingolipid storage, thus representing an early sign of cardiac involvement.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaa354","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T20:12:50Z","timestamp":1608063170000},"page":"200-208","source":"Crossref","is-referenced-by-count":22,"title":["Trabecular complexity as an early marker of cardiac involvement in Fabry disease"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-0496","authenticated-orcid":false,"given":"Antonia","family":"Camporeale","sequence":"first","affiliation":[{"name":"Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Via Morandi 30, Milan 20097, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Moroni","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lazzeroni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IRCCS Don Carlo Gnocchi Foundation, Via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Garibaldi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Parma University Hospital, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pieroni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, San Donato Hospital, Arezzo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pieruzzi","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, Department of Medicine and Surgery, University of Milano Bicocca, ASST-Monza San Gerardo Hospital, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Lusardi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Humanitas Hospital, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Spada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Torino, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Mignani","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Department, Infermi Hospital, Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Burlina","sequence":"additional","affiliation":[{"name":"Neurological Unit, St. Bassiano Hospital, Bassano del Grappa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Carubbi","sequence":"additional","affiliation":[{"name":"Metabolic Medicine Unit, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Econimo","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, Hospital of Montichiari, Spedali Civili Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, University-Hospital St. Anna, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Graziani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pica","sequence":"additional","affiliation":[{"name":"Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Via Morandi 30, Milan 20097, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Chow","sequence":"additional","affiliation":[{"name":"Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo G","family":"Camici","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Via 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