{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:37:23Z","timestamp":1776872243419,"version":"3.51.2"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004718","name":"Toulouse University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Hypertrophic cardiomyopathy (HCM) may be associated with very narrow QRS, while left ventricular hypertrophy (LVH) may increase QRS duration. We investigated the relationships between QRS duration and LV mass (LVM) in subtypes of abnormal LV wall thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Automated measurement of LVM on MRI was correlated to automated measurement of QRS duration on ECG in HCM, left ventricular non compaction (LVNC), left ventricular hypertrophy (LVH), and controls with healthy hearts. Uni and multivariate analyses were performed between groups including explanatory variables expected to influence LVM and QRS duration. The relationships between QRS duration and LVM were further studied within each group. Two hundred and twenty-one HCM, 28 LVNC, 16 LVH, and 40 controls were retrospectively included. Mean QRS duration was 92\u2009ms for HCM, 104 for LVNC, 110 for LVH, and 92 for controls (P\u2009&amp;lt;\u20090.01). Mean LVM was 100, 90, 108, and 68\u2009g\/m2 (P\u2009&amp;lt;\u20090.01). QRS duration, LVM, hypertension, maximal wall thickness, and late gadolinium enhancement were significantly linked to HCM in multivariate analysis (w\/wo bundle branch block). An independent negative correlation was found between LVM and QRS duration in the HCM group, while the relationship was reverse in LVNC, LVH, and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>QRS duration increases with LVM in LVNC, LVH, or in healthy hearts, while reverse relationship is present in HCM. These relationships were independent from other parameters. These results warrant additional investigations for refining diagnosis criteria for HCM in the future.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjci\/jeab063","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T20:09:12Z","timestamp":1616875752000},"page":"560-568","source":"Crossref","is-referenced-by-count":11,"title":["Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy"],"prefix":"10.1093","volume":"23","author":[{"given":"Guillaume","family":"Domain","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Chouquet","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Toulouse Mathematics Institute, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"R\u00e9ant","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Pessac, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanina","family":"Bongard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"},{"name":"INSERM U 1027, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Vedis","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Toulouse Mathematics Institute, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Rollin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Mandel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Delasnerie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Voglimacci-Stephanopoli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Mondoly","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Beneyto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Cariou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Delmas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Galinier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Carri\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Lafitte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Pessac, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Lairez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Ferri\u00e8res","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"},{"name":"INSERM U 1027, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Cochet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Pessac, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-1841","authenticated-orcid":false,"given":"Philippe","family":"Maury","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulh\u00e8s 31400 Toulouse, France"},{"name":"I2MC, INSERM UMR 1297, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,11]]},"reference":[{"key":"2022032516085896400_jeab063-B1","first-page":"2733","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy","volume":"39","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"2022032516085896400_jeab063-B2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.amjcard.2007.03.049","article-title":"Relation of QRS duration to mortality in a community-based cohort with hypertrophic cardiomyopathy","volume":"100","author":"Bongioanni","year":"2007","journal-title":"Am J Cardiol"},{"key":"2022032516085896400_jeab063-B3","doi-asserted-by":"crossref","first-page":"3.e1","DOI":"10.1016\/j.jelectrocard.2006.05.001","article-title":"The early repolarization variant-an electrocardiographic enigma with both QRS and J-STT anomalies","volume":"40","author":"Boineau","year":"2007","journal-title":"J Electrocardiol"},{"key":"2022032516085896400_jeab063-B4","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.hrthm.2008.05.019","article-title":"Is a \u201cNarrow and Tall\u201d QRS complex an ECG marker for sudden death?","volume":"5","author":"Wolpert","year":"2008","journal-title":"Heart Rhythm"},{"key":"2022032516085896400_jeab063-B5","doi-asserted-by":"crossref","first-page":"e251\u201361","DOI":"10.1161\/CIRCULATIONAHA.108.191097","article-title":"AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: part V: electrocardiogram changes associated with cardiac chamber hypertrophy","volume":"119","author":"Hancock","year":"2009","journal-title":"Circulation"},{"key":"2022032516085896400_jeab063-B6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/anec.12053","article-title":"Quantitative electrocardiographic measures, neuromuscular disorders, and survival in left ventricular hypertrabeculation\/noncompaction","volume":"18","author":"St\u00f6llberger","year":"2013","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2022032516085896400_jeab063-B7","first-page":"176","article-title":"Magnetic resonance imaging of myocardial fibrosis in hypertrophic cardiomyopathy","volume":"3","author":"Wilson","year":"2002","journal-title":"Tex Heart Inst J"},{"key":"2022032516085896400_jeab063-B8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jacc.2005.03.045","article-title":"Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging","volume":"46","author":"Petersen","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2022032516085896400_jeab063-B9","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1053\/euhj.2000.2339","article-title":"Hypertensive heart disease. A complex syndrome or a hypertensive cardiomyopathy?","volume":"21","author":"Lip","year":"2000","journal-title":"Eur Heart J"},{"key":"2022032516085896400_jeab063-B10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jelectrocard.2019.07.013","article-title":"New standards for ECG equipment","volume":"57","author":"Young","year":"2019","journal-title":"J Electrocardiol"},{"key":"2022032516085896400_jeab063-B11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jacc.2007.01.024","article-title":"Recommendations for the standardization and interpretation of the electrocardiogram: part I: the electrocardiogram and its technology","volume":"49","author":"Kligfield","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2022032516085896400_jeab063-B12","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1540-8167.2010.01743.x","article-title":"Reliability and reproducibility of QRS duration in the selection of candidates for cardiac resynchronization therapy","volume":"8","author":"De Guillebon","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2022032516085896400_jeab063-B13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/europace\/eup043","article-title":"Precise electrocardiographic measurements and clinical sense","volume":"11","author":"Malik","year":"2009","journal-title":"Europace"},{"key":"2022032516085896400_jeab063-B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ahj.2018.02.014","article-title":"Comparison of automated interval measurements by widely used algorithms in digital electrocardiographs","volume":"200","author":"Kligfield","year":"2018","journal-title":"Am Heart J"},{"key":"2022032516085896400_jeab063-B15","volume-title":"ECAPS-12C User Guide: Interpretation Standard (Revision A)","author":"Kohden","year":"2001"},{"key":"2022032516085896400_jeab063-B16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jacc.2008.12.014","article-title":"AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval","volume":"53","author":"Rautaharju","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2022032516085896400_jeab063-B17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","article-title":"Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings","volume":"57","author":"Devereux","year":"1986","journal-title":"Am J Cardiol"},{"key":"2022032516085896400_jeab063-B18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1081\/JCMR-120013298","article-title":"Improved accuracy of quantitative assessment of left ventricular volume and ejection fraction by geometric models with steady-state free precession","volume":"4","author":"Thiele","year":"2002","journal-title":"J Cardiovasc Magn Reson"},{"key":"2022032516085896400_jeab063-B19","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jacc.2008.12.013","article-title":"AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances","volume":"53","author":"Surawicz","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2022032516085896400_jeab063-B20","author":"Ekinci"},{"key":"2022032516085896400_jeab063-B21","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0002-9149(81)90068-0","article-title":"Patterns and significance of distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy. A wide angle, two dimensional echocardiographic study of 125 patients","volume":"48","author":"Maron","year":"1981","journal-title":"Am J Cardiol"},{"key":"2022032516085896400_jeab063-B22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11906-019-0910-6","article-title":"Recent advances in imaging of hypertensive heart disease","volume":"21","author":"Schumann","year":"2019","journal-title":"Curr Hypertens Rep"},{"key":"2022032516085896400_jeab063-B23","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/eurheartj\/ehr397","article-title":"Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes","volume":"33","author":"La Gerche","year":"2012","journal-title":"Eur Heart J"},{"key":"2022032516085896400_jeab063-B24","doi-asserted-by":"crossref","first-page":"e003285","DOI":"10.1161\/CIRCIMAGING.115.003285","article-title":"T1 mapping in discrimination of hypertrophic phenotypes: hypertensive heart disease and hypertrophic cardiomyopathy","volume":"8","author":"Hinojar","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022032516085896400_jeab063-B25","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/0002-9149(82)90213-2","article-title":"Effect of ventricular hypertrophy on conduction velocity of activation front in the ventricular myocardium","volume":"49","author":"Toyoshima","year":"1982","journal-title":"Am J Cardiol"},{"key":"2022032516085896400_jeab063-B26","article-title":"The myocardial phenotype of Fabry disease pre-hypertrophy and pre-detectable storage","author":"Augusto","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022032516085896400_jeab063-B27","doi-asserted-by":"crossref","first-page":"e003121","DOI":"10.1161\/CIRCEP.115.003121","article-title":"Clinical spectrum of PRKAG2 syndrome","volume":"9","author":"Porto","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022032516085896400_jeab063-B28","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1749-6632.1957.tb36683.x","article-title":"Excitation of the left ventricular wall of the dog and goat","volume":"65","author":"Durrer","year":"1957","journal-title":"Ann N Y Acad Sci"},{"key":"2022032516085896400_jeab063-B29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00380-013-0423-1","article-title":"Suppression of ventricular fibrillation by electrical modification of the Purkinje system in hypertrophic cardiomyopathy","volume":"29","author":"Yokoshiki","year":"2014","journal-title":"Heart Vessels"},{"key":"2022032516085896400_jeab063-B30","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.CIR.80.5.1259","article-title":"Electrophysiologic abnormalities in patients with hypertrophic cardiomyopathy. A consecutive analysis in 155 patients","volume":"80","author":"Fananapazir","year":"1989","journal-title":"Circulation"},{"key":"2022032516085896400_jeab063-B31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1536\/jhj.45.347","article-title":"Abnormal His-Purkinje system conduction leading to complete atrioventricular block in patients with hypertrophic cardiomyopathy: a report of 3 cases","volume":"45","author":"Doven","year":"2004","journal-title":"Jpn Heart J"},{"key":"2022032516085896400_jeab063-B32","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/CIRCULATIONAHA.105.565804","article-title":"Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration","volume":"113","author":"Wiegerinck","year":"2006","journal-title":"Circulation"},{"key":"2022032516085896400_jeab063-B33","doi-asserted-by":"crossref","first-page":"iii102","DOI":"10.1093\/europace\/euy226","article-title":"Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities","volume":"20","author":"Lyon","year":"2018","journal-title":"Europace"},{"key":"2022032516085896400_jeab063-B34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2015.10.030","article-title":"Role of connexin 43 in cardiovascular diseases","volume":"768","author":"Michela","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"2022032516085896400_jeab063-B35","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/CIRCIMAGING.114.002411","article-title":"Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy","volume":"7","author":"Captur","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022032516085896400_jeab063-B36","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/ehjci\/jey022","article-title":"Myocardial T1 mapping and extracellular volume quantification in patients with left ventricular non-compaction cardiomyopathy","volume":"19","author":"Araujo-Filho","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022032516085896400_jeab063-B37","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.CIR.88.3.864","article-title":"Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts","volume":"88","author":"Peters","year":"1993","journal-title":"Circulation"},{"key":"2022032516085896400_jeab063-B38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12968-017-0408-9","article-title":"Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2 and extracellular volume: a consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)","volume":"20","author":"Messroghli","year":"2018","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/23\/4\/560\/42971886\/jeab063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/23\/4\/560\/42971886\/jeab063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T23:55:48Z","timestamp":1724716548000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/23\/4\/560\/6220377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,11]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,11]]},"published-print":{"date-parts":[[2022,3,22]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jeab063","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2021,4,11]]}}}