{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:14:02Z","timestamp":1782202442076,"version":"3.54.5"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"American Heart Association predoctoral Fellowship","award":["20PRE35200392"],"award-info":[{"award-number":["20PRE35200392"]}]},{"name":"Wallace H. Coulter chair funds"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To characterize the dynamic nature of the left ventricular outflow tract (LVOT) geometry and flow rate in patients following transcatheter mitral valve replacement (TMVR) with anterior leaflet laceration (LAMPOON) and derive insights to help guide future patient selection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Time-resolved LVOT geometry and haemodynamics were analysed with post-procedure computed tomography and echocardiography in subjects (N\u2009=\u200919) from the LAMPOON investigational device exemption trial. A novel post hoc definition for LVOT obstruction was employed to account for systolic flow rate and quality of life improvement [obstruction was defined as LVOT gradient &amp;gt;30\u2009mmHg or LVOT effective orifice area (EOA) \u22641.15 cm2]. The neo-LVOT and skirt neo-LVOT were observed to vary substantially in area throughout systole (64\u2009\u00b1\u200927% and 25\u2009\u00b1\u200914% change in area, respectively). The peak systolic flow rate occurred most commonly just prior to mid-systole, while minimum neo-LVOT (and skirt neo-LVOT) area occurred most commonly in early-diastole. Subjects with LVOT obstruction (n\u2009=\u20095) had smaller skirt neo-LVOT values across systole. Optimal thresholds for skirt neo-LVOT area were phase-specific (260, 210, 200, and 180 mm2 for early-systole, peak flow, mid-systole, and end-systole, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The LVOT geometry and flow rate exhibit dynamic characteristics following TMVR with LAMPOON. Subjects with LVOT obstruction had smaller skirt neo-LVOT areas across systole. The authors recommend the use of phase-specific threshold values for skirt neo-LVOT area to guide future patient selection for this procedure. LVOT EOA is a \u2018flow-independent\u2019 metric which has the potential to aid in characterizing LVOT obstruction severity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab074","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T19:25:33Z","timestamp":1617823533000},"page":"650-662","source":"Crossref","is-referenced-by-count":17,"title":["Dynamic nature of the LVOT following transcatheter mitral valve replacement with LAMPOON: new insights from post-procedure imaging"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-4088","authenticated-orcid":false,"given":"Keshav","family":"Kohli","sequence":"first","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Suite 200, 387 Technology Circle , Atlanta, GA 30313-2412, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglun Alan","family":"Wei","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Suite 200, 387 Technology Circle , Atlanta, GA 30313-2412, USA"},{"name":"Department of Biomedical Engineering, University of Massachusetts Lowell , Lowell, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Sadri","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Suite 200, 387 Technology Circle , Atlanta, GA 30313-2412, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaffar M","family":"Khan","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health , Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Lisko","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, Emory University Hospital , Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Netto","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Suite 200, 387 Technology Circle , Atlanta, GA 30313-2412, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, Emory University Hospital , Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Blanke","sequence":"additional","affiliation":[{"name":"Department of Radiology, St. Paul's Hospital & University of British Columbia , Vancouver, British Columbia, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Oshinski","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Science, Emory University School of Medicine , Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-6673","authenticated-orcid":false,"given":"Robert J","family":"Lederman","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health , Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit P","family":"Yoganathan","sequence":"additional","affiliation":[{"name":"Wallace H. 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