{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:37:08Z","timestamp":1771490228110,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL132011"],"award-info":[{"award-number":["K23HL132011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR000113-05"],"award-info":[{"award-number":["KL2TR000113-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002494"],"award-info":[{"award-number":["UL1TR002494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We aimed to determine the prevalence of right ventricular (RV) systolic dysfunction on cardiovascular magnetic resonance imaging (CMR) and its impact on long-term adverse outcomes in a large cohort of cancer survivors treated with anthracycline-based chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive cancer survivors treated with anthracyclines who underwent clinical CMR for suspected anthracycline-related cardiomyopathy were studied. The primary endpoint was a composite of all-cause death or major adverse cardiac events (MACE): heart failure hospitalization, heart transplantation, ventricular assist device implantation, resuscitated cardiac arrest, or life-threatening ventricular arrhythmia. The secondary endpoints were all-cause death, and cardiac death or MACE. Among 249 survivors who underwent CMR at a median of 2.9\u2009years after cancer treatment, RV systolic dysfunction was present in 54 (21.7%). Of these, 50 (92.6%) had an abnormal left ventricular ejection fraction (LVEF). At a median follow-up time after the CMR of 2.7\u2009years, 105 survivors experienced the primary endpoint. On Kaplan\u2013Meier analyses, the cumulative incidence of the primary endpoint was significantly higher in survivors with abnormal RVEF compared with those with normal RVEF (P\u2009=\u20090.002). However, on Cox multivariable analyses, RVEF was not associated with the primary endpoint (HR 1.04 per 5% decrease; 95% CI 0.93\u20131.17; P\u2009=\u20090.46) after adjustment for non-imaging variables and LVEF. RVEF was also not associated with the secondary endpoints.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among anthracycline-treated cancer survivors undergoing CMR for suspected cardiotoxicity, RV systolic dysfunction was present in one in five cases, accompanied by LV systolic dysfunction in nearly all cases, and was not independently associated with long-term outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab137","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T19:12:23Z","timestamp":1624648343000},"page":"1222-1230","source":"Crossref","is-referenced-by-count":11,"title":["Long-term prognostic value of right ventricular dysfunction on cardiovascular magnetic resonance imaging in anthracycline-treated cancer survivors"],"prefix":"10.1093","volume":"23","author":[{"given":"Sanya","family":"Chhikara","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hooks","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pal Satyajit Singh","family":"Athwal","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Hughes","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed F","family":"Ismail","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Joppa","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik S","family":"Velangi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhjot S","family":"Nijjar","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne H","family":"Blaes","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-4999","authenticated-orcid":false,"given":"Chetan","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"2022102718410549000_jeab137-B1","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/jnci\/djs317","article-title":"Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study","volume":"104","author":"Bowles","year":"2012","journal-title":"J Natl Cancer 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cardiovascular disease","volume":"14","author":"Purmah","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022102718410549000_jeab137-B5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1530\/ERP-16-0020","article-title":"Right heart function deteriorates in breast cancer patients undergoing anthracycline-based chemotherapy","volume":"3","author":"Boczar","year":"2016","journal-title":"Echo Res Pract"},{"key":"2022102718410549000_jeab137-B6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/postgradmedj-2016-134286","article-title":"Alterations in the echocardiographic variables of the right ventricle in asymptomatic patients with breast cancer during anthracycline chemotherapy","volume":"93","author":"Abdar Esfahani","year":"2017","journal-title":"Postgrad Med J"},{"key":"2022102718410549000_jeab137-B7","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/ejechocard\/jer142","article-title":"Assessment of right ventricular functions 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