{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:18:50Z","timestamp":1792793930551,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Research, Development, and Innovation Fund of Hungary","award":["NVKP_16-1-2016-0017"],"award-info":[{"award-number":["NVKP_16-1-2016-0017"]}]},{"name":"National Research, Development, and Innovation Office of Hungary","award":["K120277"],"award-info":[{"award-number":["K120277"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Research, Development, and Innovation Office of Hungary","award":["K135076 to BM"],"award-info":[{"award-number":["K135076 to BM"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Thematic Excellence Program","award":["2020-4.1.1.-TKP2020"],"award-info":[{"award-number":["2020-4.1.1.-TKP2020"]}]},{"name":"Ministry for Innovation and Technology in Hungary","id":[{"id":"https:\/\/ror.org\/02ey3ab96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"New National Excellence Program","award":["\u00daNKP-20-3-II-SE-54"],"award-info":[{"award-number":["\u00daNKP-20-3-II-SE-54"]}]},{"name":"Ministry for Innovation and Technology in Hungary","id":[{"id":"https:\/\/ror.org\/02ey3ab96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We sought to investigate the correlation between speckle-tracking echocardiography (STE)-derived myocardial work (MW) and invasively measured contractility in a rat model of athlete's heart. We also assessed MW in elite athletes and explored its association with cardiopulmonary exercise test (CPET)-derived aerobic capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Sixteen rats underwent a 12-week swim training program and were compared to controls (n\u2009=\u200916). STE was performed to assess global longitudinal strain (GLS), which was followed by invasive pressure-volume analysis to measure contractility [slope of end-systolic pressure\u2013volume relationship (ESPVR)]. Global MW index (GMWI) was calculated from GLS curves and left ventricular (LV) pressure recordings. In the human investigations, 20 elite swimmers and 20 healthy sedentary controls were enrolled. GMWI was calculated through the simultaneous evaluation of GLS and non-invasively approximated LV pressure curves at rest. All subjects underwent CPET to determine peak oxygen uptake (VO2\/kg). Exercised rats exhibited higher values of GLS, GMWI, and ESPVR than controls (\u221220.9\u2009\u00b1\u20091.7 vs. \u221217.6\u2009\u00b1\u20091.9%, 2745\u2009\u00b1\u2009280 vs. 2119\u2009\u00b1\u2009272\u2009mmHg\u00b7%, 3.72\u2009\u00b1\u20090.72 vs. 2.61\u2009\u00b1\u20090.40\u2009mmHg\/\u03bcL, all PExercise &amp;lt; 0.001). GMWI correlated robustly with ESPVR (r\u2009=\u20090.764, P\u2009&amp;lt;\u20090.001). In humans, regular exercise training was associated with decreased GLS (\u221217.6\u2009\u00b1\u20091.5 vs. \u221218.8\u2009\u00b1\u20090.9%, PExercise = 0.002) but increased values of GMWI at rest (1899\u2009\u00b1\u2009136 vs. 1755\u2009\u00b1\u2009234\u2009mmHg\u00b7%, PExercise = 0.025). GMWI exhibited a positive correlation with VO2\/kg (r\u2009=\u20090.527, P\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GMWI precisely reflected LV contractility in a rat model of exercise-induced LV hypertrophy and captured the supernormal systolic performance in human athletes even at rest. Our findings endorse the utilization of MW analysis in the evaluation of the athlete\u2019s heart.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab162","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T07:12:57Z","timestamp":1628233977000},"page":"188-197","source":"Crossref","is-referenced-by-count":44,"title":["Novel insights into the athlete\u2019s heart: is myocardial work the new champion of systolic function?"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-4131","authenticated-orcid":false,"given":"M\u00e1rton","family":"Tokodi","sequence":"first","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-7735","authenticated-orcid":false,"given":"Attila","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-0638","authenticated-orcid":false,"given":"Alexandra","family":"F\u00e1bi\u00e1n","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-5620","authenticated-orcid":false,"given":"B\u00e1lint K\u00e1roly","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-2070","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Hizoh","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mih\u00e1ly","family":"Ruppert","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-4775","authenticated-orcid":false,"given":"Alex Ali","family":"Sayour","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-0438","authenticated-orcid":false,"given":"B\u00e1lint Andr\u00e1s","family":"Barta","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Kiss","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-4321","authenticated-orcid":false,"given":"N\u00f3ra","family":"Syd\u00f3","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-8000","authenticated-orcid":false,"given":"Emese","family":"Csulak","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-1985","authenticated-orcid":false,"given":"Zsuzsanna","family":"Lad\u00e1nyi","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-0723","authenticated-orcid":false,"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, Budapest 1122, 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