{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:14Z","timestamp":1787008694429,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"PLN Genetic Heart Disease Foundation, Netherlands Heart Institute, the Dutch Heart Foundation","award":["CVON2015-12 eDETECT"],"award-info":[{"award-number":["CVON2015-12 eDETECT"]}]},{"name":"PLN Genetic Heart Disease Foundation, Netherlands Heart Institute, the Dutch Heart Foundation","award":["CVON2018-30 PREDICT2"],"award-info":[{"award-number":["CVON2018-30 PREDICT2"]}]},{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dutch Heart Foundation (CVON PREDICT Young Talent Program) and the Leducq Foundation"},{"name":"UCL Hospitals NIHR Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\u2003<\/jats:title>\n                    <jats:p>Phospholamban (PLN) p.Arg14del mutation carriers are at risk of developing malignant ventricular arrhythmias (VAs) and\/or heart failure. Currently, left ventricular ejection fraction (LVEF) plays an important role in risk assessment for VA in these individuals. We aimed to study the incremental prognostic value of left ventricular mechanical dispersion (LVMD) by echocardiographic deformation imaging for prediction of sustained VA in PLN p.Arg14del mutation carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We included 243 PLN p.Arg14del mutation carriers, which were classified into three groups according to the \u201845\/45\u2019 rule: (i) normal left ventricular (LV) function, defined as preserved LVEF \u226545% with normal LVMD \u226445 ms (n = 139), (ii) mechanical LV dysfunction, defined as preserved LVEF \u226545% with abnormal LVMD &amp;gt;45 ms (n = 63), and (iii) overt LV dysfunction, defined as reduced LVEF &amp;lt;45% (n = 41). During a median follow-up of 3.3 (interquartile range 1.8\u20136.0) years, sustained VA occurred in 35 individuals. The negative predictive value of having normal LV function at baseline was 99% [95% confidence interval (CI): 92\u2013100%] for developing sustained VA. The positive predictive value of mechanical LV dysfunction was 20% (95% CI: 15\u201327%). Mechanical LV dysfunction was an independent predictor of sustained VA in multivariable analysis [hazard ratio adjusted for VA history: 20.48 (95% CI: 2.57\u2013162.84)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u2003<\/jats:title>\n                    <jats:p>LVMD has incremental prognostic value on top of LVEF in PLN p.Arg14del mutation carriers, particularly in those with preserved LVEF. The \u201845\/45\u2019 rule is a practical approach to echocardiographic risk stratification in this challenging group of patients. This approach may also have added value in other diseases where LVEF deterioration is a relative late marker of myocardial dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab178","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T15:12:01Z","timestamp":1629299521000},"page":"1492-1501","source":"Crossref","is-referenced-by-count":6,"title":["Optimal echocardiographic assessment of myocardial dysfunction for arrhythmic risk stratification in phospholamban mutation carriers"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-5461","authenticated-orcid":false,"given":"Karim","family":"Taha","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht, The Netherlands"},{"name":"Netherlands Heart Institute , Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom E","family":"Verstraelen","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Cardiology, Amsterdam University Medical Center, Location Academic Medical Center , Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-2034","authenticated-orcid":false,"given":"Remco","family":"de Brouwer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne H A C M","family":"de Bruin-Bon","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Cardiology, Amsterdam University Medical Center, Location Academic Medical Center , Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten J","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter P","family":"Te Rijdt","sequence":"additional","affiliation":[{"name":"Netherlands Heart Institute , Utrecht, The Netherlands"},{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen, The Netherlands"},{"name":"Department of Genetics, University Medical Center Groningen, University of Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berto J","family":"Bouma","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Cardiology, Amsterdam University Medical Center, Location Academic Medical Center , Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A","family":"Doevendans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht, The Netherlands"},{"name":"Netherlands Heart Institute , Utrecht, The Netherlands"},{"name":"Central Military Hospital , Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert W","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht, The Netherlands"},{"name":"Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London , London , UK"},{"name":"Health Data Research UK and Institute of Health Informatics, University College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A 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