{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:46:19Z","timestamp":1793407579064,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006356","name":"University of Southern Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region of Southern Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Aortic valve calcification (AVC) detected by non-contrast computed tomography (NCCT) associates with morbidity and mortality in patients with aortic valve stenosis. However, the importance of AVC in the general population is sparsely evaluated. We intend to describe the associations between AVC score on NCCT and echocardiographic findings as left atrial (LA) dilatation, left ventricular (LV) hypertrophy, aortic valve area (AVA), peak velocity, mean gradient, and aortic valve replacement (AVR) in a population with AVC scores \u2265300 AU.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Of 10 471 males aged 65\u201374\u2009years from the Danish Cardiovascular Screening trial (DANCAVAS), participants with AVC score \u2265300\u2009AU were invited for transthoracic echocardiography and 828 (77%) of 1075 accepted the invitation. AVC scores were categorized (300\u2013599, 600\u2013799, 800\u20131199, and \u22651200\u2009AU). AVR was obtained from registries. AVC was significantly associated with a steady increase in LA dilation (10.5%, 16.3%, 15.8%, 19.6%, P\u2009=\u20090.031), LV hypertrophy (3.9%, 6.6%, 8.9%, 10.1%, P\u2009=\u20090.021), peak velocity (1.7, 1.9, 2.1, 2.8\u2009m\/s, P\u2009=\u20090001), mean gradient (6, 8, 11, 19\u2009mmHg, P\u2009=\u20090.0001), and a decrease in AVA (2.0, 1.9, 1.7, 1.3 cm2, P\u2009=\u20090.0001). The area under the curve was 0.79, 0.93, and 0.92 for AVA \u22641.5 cm2, peak velocity \u22653.0\u2009m\/s, and mean gradient \u226520\u2009mmHg, respectively, and the associated optimal AVC score thresholds were 734, 1081, and 1019\u2009AU. AVC\u2009&amp;gt;\u20091200\u2009AU was associated with AVR (P\u2009&amp;lt;\u20090.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among males from the background population, increasing AVC scores were associated with LA dilatation, LV hypertrophy, AVA, peak aortic velocity, mean aortic gradient, and AVR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab182","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T14:54:19Z","timestamp":1631026459000},"page":"177-184","source":"Crossref","is-referenced-by-count":11,"title":["Aortic valve calcification among elderly males from the general population, associated echocardiographic findings, and clinical implications"],"prefix":"10.1093","volume":"23","author":[{"given":"Lida","family":"Khurrami","sequence":"first","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, Odense 5000, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, Odense 5000, Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital, Blegdamsvej 9, 2100 K\u00f8benhavn, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes Sanddal","family":"Lindholt","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, Odense 5000, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi Sancez","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, Odense 5000, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maise Hoeigaard","family":"Fredgart","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, Odense 5000, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse M","family":"Obel","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, Odense 5000, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming Hald","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sygehus Lillebaelt, Beriderbakken 4, 7100 Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazina","family":"Urbonaviciene","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Regional Hospital Central Jutland, Falkevej 1A, 8600 Silkeborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Lambrechtsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Baag\u00f8es Alle 31, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-4826","authenticated-orcid":false,"given":"Axel Cosmus Pyndt","family":"Diederichsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, J. 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