{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:16:15Z","timestamp":1793578575260,"version":"4.5.0"},"reference-count":151,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem will require detailed phenotyping of the contributions of fibrosis, microcirculatory disturbance, abnormal metabolism, and sympathetic innervation, among other mechanisms. For this reason, an imaging strategy for the detection of HF risk needs to not only detect subclinical LV dysfunction (LVD) but also characterize its pathogenesis. At present, it is possible to identify individuals with DM at increased risk HF, and there is evidence that cardioprotection may be of benefit. However, there is insufficient justification for HF screening, because we need stronger evidence of the links between the detection of LVD, treatment, and improved outcome. This review discusses the options for screening for LVD, the potential means of identifying the underlying mechanisms, and the pathways to treatment.<\/jats:p>","DOI":"10.1093\/ehjci\/jeab220","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T22:45:35Z","timestamp":1633560335000},"page":"e62-e84","source":"Crossref","is-referenced-by-count":34,"title":["Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging"],"prefix":"10.1093","volume":"23","author":[{"given":"Thomas H","family":"Marwick","sequence":"first","affiliation":[{"name":"Baker Heart and Diabetes Institute , 75 Commercial Road , Melbourne, VIC 3004,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-1723","authenticated-orcid":false,"given":"Alessia","family":"Gimelli","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio , Via Moruzzi, 1 , 56124 Pisa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-4384","authenticated-orcid":false,"given":"Sven","family":"Plein","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Center & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-0500","authenticated-orcid":false,"given":"Jeroen J","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre (LUMC) , Leiden,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillippe","family":"Charron","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM UMRS 1166 and ICAN Institute , Paris,","place":["France"]},{"name":"APHP, Centre de r\u00e9f\u00e9rence pour les maladies cardiaques h\u00e9r\u00e9ditaires ou rares, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-2737","authenticated-orcid":false,"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre , Albinusdreef 2 , Leiden 2300RC,","place":["The 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Bari,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylem","family":"Levelt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital \u00a0 , Groby Road , Leicester LE3 9QF,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal","family":"Maurovich-Horvat","sequence":"additional","affiliation":[{"name":"MTA-SE Cardiovascular Imaging Research Group, Medical Imaging Centre, Semmelweis University , 2 Koranyi u ., 1083 Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-5645","authenticated-orcid":false,"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford , Headley Way , Oxford OX3 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C. Iliescu\u201d , Bucharest,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Galderisi","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University , Naples,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Derumeaux","sequence":"additional","affiliation":[{"name":"IMRB \u2013 Inserm U955 Senescence , metabolism and cardiovascular diseases 8, rue du G\u00e9n\u00e9ral Sarrail, 94010 Cr\u00e9teil,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Reviewers: This document was reviewed by members of the 2020\u20132022 EACVI Scientific Documents Committee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"B\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe 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