{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:32:57Z","timestamp":1790429577683,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Transcatheter aortic valve replacement (TAVR) procedural planning requires computed tomography angiography (CTA) which allows for the assessment of left ventricular global longitudinal strain (CTA-LVGLS). There is, however, limited data on the feasibility of CTA-LVGLS, and its prognostic value. This study sought to evaluate the incremental prognostic value of baseline CTA-LVGLS, change in CTA-LVGLS after TAVR, and their association with post-TAVR outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 431 patients who underwent multiphasic gated CTA using dual-source system for TAVR planning at baseline and 1-month follow-up were included [median (interquartile range) age, 83 (77\u201387) years; 44% female, STS-PROM score: 3.3 (2.3\u20135.1)%, Echo-left ventricular ejection fraction (LVEF): 60 (55\u201365)%, CTA-LVGLS: \u221218.0 (\u221221.6 to \u221214.2)%, feasible in 97% of patients]. CTA-LVGLS was measured using dedicated feature-tracking software. Over a median follow-up of 19 (13\u201327) months, 99 endpoints of all-cause death or heart failure hospitalization occurred. The relative hazard of the endpoint increased as baseline CTA-LVGLS worsened with \u221218.2% as the threshold for higher events (P\u2009=\u20090.005). After adjustment for baseline characteristics, CTA-LVGLS remained associated with the endpoint [hazard ratio (HR) (95% confidence interval, CI), 1.08 (1.03\u20131.14); P\u2009=\u20090.005] and incrementally improved prognostication (C-index difference, 0.026). Although CTA-LVGLS improved after TAVR [\u221218.3 (\u221221.6 to \u221214.3)% vs. \u221218.7 (\u221221.9 to \u221215.4)%, P\u2009&amp;lt;\u20090.001], patients without CTA-LVGLS improvement had higher risk of the endpoint than those with improvement or preserved baseline global longitudinal strain [HR (95% CI), 1.92 (1.19\u20133.12); P\u2009=\u20090.008].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this predominantly low-risk TAVR cohort of patients, mostly with normal LVEF, assessment of CTA-LVGLS is highly feasible improving risk stratification by providing independent and incremental prognostic value over clinical and echocardiographic characteristics.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab229","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T12:18:15Z","timestamp":1636114695000},"page":"476-484","source":"Crossref","is-referenced-by-count":17,"title":["Association of baseline and change in global longitudinal strain by computed tomography with post-transcatheter aortic valve replacement outcomes"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7235-5551","authenticated-orcid":false,"given":"Miho","family":"Fukui","sequence":"first","affiliation":[{"name":"Cardiovascular Imaging Research Center and Core Lab, Minneapolis Heart Institute Foundation, 920 E 28th Street, Suite 100, Minneapolis, MN 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center and Core Lab, Minneapolis Heart Institute Foundation, 920 E 28th Street, Suite 100, Minneapolis, MN 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo B C","family":"Lopes","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center and Core Lab, Minneapolis Heart Institute Foundation, 920 E 28th Street, Suite 100, Minneapolis, MN 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa I","family":"Stanberry","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center and Core Lab, Minneapolis Heart Institute Foundation, 920 E 28th Street, Suite 100, Minneapolis, MN 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Garcia","sequence":"additional","affiliation":[{"name":"Valve Science Center, Minneapolis Heart Institute Foundation, 920 E 28th Street, Minneapolis, MN, 55407, USA"},{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital,\u00a0800 E 28th Street, Minneapolis, MN, 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"G\u00f6ssl","sequence":"additional","affiliation":[{"name":"Valve Science Center, Minneapolis Heart Institute Foundation, 920 E 28th Street, Minneapolis, MN, 55407, USA"},{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital,\u00a0800 E 28th Street, Minneapolis, MN, 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Enriquez-Sarano","sequence":"additional","affiliation":[{"name":"Valve Science Center, Minneapolis Heart Institute Foundation, 920 E 28th Street, Minneapolis, MN, 55407, USA"},{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital,\u00a0800 E 28th Street, Minneapolis, MN, 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak N","family":"Bapat","sequence":"additional","affiliation":[{"name":"Valve Science Center, Minneapolis Heart Institute Foundation, 920 E 28th Street, Minneapolis, MN, 55407, USA"},{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital,\u00a0800 E 28th Street, Minneapolis, MN, 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sorajja","sequence":"additional","affiliation":[{"name":"Valve Science Center, Minneapolis Heart Institute Foundation, 920 E 28th Street, Minneapolis, MN, 55407, USA"},{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital,\u00a0800 E 28th Street, Minneapolis, MN, 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Lesser","sequence":"additional","affiliation":[{"name":"Valve Science Center, Minneapolis Heart Institute Foundation, 920 E 28th Street, Minneapolis, MN, 55407, USA"},{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital,\u00a0800 E 28th Street, Minneapolis, MN, 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o 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