{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T20:55:08Z","timestamp":1774904108722,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National, Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1K23HL144907"],"award-info":[{"award-number":["1K23HL144907"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Prediction of mitral (MR) and tricuspid (TR) regurgitation progression on transthoracic echocardiography (TTE) is needed to personalize valvular surveillance intervals and prognostication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Structured TTE report data at Beth Israel Deaconess Medical Center, 26 January 2000\u201331 December 2017, were used to determine time to progression (\u22651+ increase in severity). TTE predictors of progression were used to create a progression score, externally validated at Massachusetts General Hospital, 1 January 2002\u201331 December 2019. In the derivation sample (MR, N = 34 933; TR, N = 27 526), only 5379 (15.4%) individuals with MR and 3630 (13.2%) with TR had progression during a median interquartile range) 9.0 (4.1\u201313.4) years of follow-up. Despite wide inter-individual variability in progression rates, a score based solely on demographics and TTE variables identified individuals with a five- to six-fold higher rate of MR\/TR progression over 10 years (high- vs. low-score tertile, rate of progression; MR 20.1% vs. 3.3%; TR 21.2% vs. 4.4%). Compared to those in the lowest score tertile, those in the highest tertile of progression had a four-fold increased risk of mortality. On external validation, the score demonstrated similar performance to other algorithms commonly in use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Four-fifths of individuals had no progression of MR or TR over two decades. Despite wide interindividual variability in progression rates, a score, based solely on TTE parameters, identified individuals with a five- to six-fold higher rate of MR\/TR progression. Compared to the lowest tertile, individuals in the highest score tertile had a four-fold increased risk of mortality. Prediction of long-term MR\/TR progression is not only feasible but prognostically important.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjci\/jeab254","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T04:45:59Z","timestamp":1636692359000},"page":"1606-1616","source":"Crossref","is-referenced-by-count":6,"title":["Development and validation of an echocardiographic algorithm to predict long-term mitral and tricuspid regurgitation progression"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-6141","authenticated-orcid":false,"given":"Jordan B","family":"Strom","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center , 375 Longwood Avenue, 4th floor, Boston, MA 02215 , USA"},{"name":"Richard A. and Susan F. 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Smith Center for Outcomes Research in Cardiology, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA , USA"},{"name":"Harvard Medical School , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evin","family":"Yucel","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA , USA"},{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Tanguturi","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA , USA"},{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M","family":"Hyland","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center , 375 Longwood Avenue, 4th floor, Boston, MA 02215 , USA"},{"name":"Harvard Medical School , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J","family":"Markson","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA , USA"},{"name":"Information Systems, Beth Israel Deaconess Medical Center , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruv S","family":"Kazi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center , 375 Longwood Avenue, 4th floor, Boston, MA 02215 , USA"},{"name":"Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA , USA"},{"name":"Harvard Medical School , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghan","family":"Cui","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA , USA"},{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Hung","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA , USA"},{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W","family":"Yeh","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center , 375 Longwood Avenue, 4th floor, Boston, MA 02215 , USA"},{"name":"Richard A. and Susan F. 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