{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:49:30Z","timestamp":1790682570475,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2013T093"],"award-info":[{"award-number":["2013T093"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Thorax Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Aortic wall shear stress (WSS) distributions in bicuspid aortic valve (BAV) patients have been associated with aortic dilatation, but prospective, longitudinal data are missing. This study assessed differences in aortic WSS distributions between BAV patients and healthy controls and determined the association of WSS with aortic growth in patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Sixty subjects underwent four-dimensional (4D) flow cardiovascular magnetic resonance of the thoracic aorta (32 BAV patients and 28 healthy controls). Peak velocity, pulse wave velocity, aortic distensibility, peak systolic WSS (magnitude, axial, and circumferential), and WSS angle were assessed. WSS angle is defined as the angle between the WSSmagnitude and WSSaxial component. In BAV patients, three-year computed tomography angiography-based aortic volumetric growth was determined in the proximal and entire ascending aorta. WSSaxial was significantly lower in BAV patients compared with controls (0.93 vs. 0.72 Pa, P = 0.047) and WSScircumferential and WSS angle were significantly higher (0.29 vs. 0.64 Pa and 18\u00b0 vs. 40\u00b0, both P &amp;lt; 0.001). Significant volumetric growth of the proximal ascending aorta occurred in BAV patients (from 49.1 to 52.5 cm3, P = 0.003). In multivariable analysis corrected for baseline aortic volume and diastolic blood pressure, WSS angle was the only parameter independently associated with proximal aortic growth (P = 0.031). In the entire ascending aorta, besides the WSS angle, the WSSmagnitude was also independently associated with growth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Increased WSScircumferential and especially WSS angle are typical in BAV patients. WSS angle was found to predict aortic growth. These findings highlight the potential role of WSS measurements in BAV patients to stratify patients at risk for aortic dilation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab290","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T20:08:50Z","timestamp":1639858130000},"page":"1680-1689","source":"Crossref","is-referenced-by-count":39,"title":["Wall shear stress angle is associated with aortic growth in bicuspid aortic valve patients"],"prefix":"10.1093","volume":"23","author":[{"given":"Savine C S","family":"Minderhoud","sequence":"first","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-3830","authenticated-orcid":false,"given":"Jolien W","family":"Roos-Hesselink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca G","family":"Chelu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia R","family":"Bons","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allard T","family":"van den Hoven","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-4033","authenticated-orcid":false,"given":"Suze-Anne","family":"Korteland","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemien E","family":"van den Bosch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo P J","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda J","family":"Wentzel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-2006","authenticated-orcid":false,"given":"Alexander","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, University Medical 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