{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:32:57Z","timestamp":1794360777897,"version":"4.9.0"},"reference-count":120,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heightened interest in tricuspid regurgitation (TR) stems from the consistent association of mortality with greater severity of TR, and a low use of surgical solutions in the setting of high in-hospital mortality attributed to the late presentation of the disease. The delay in intervention is likely related to a limited understanding of the valvular\/ventricular anatomy and disease pathophysiology, along with an underestimation of TR severity by standard imaging modalities. With the rapid development of transcatheter solutions which have shown early safety and efficacy, there is a growing need to understand and accurately diagnose the valvular disease process in order to determine appropriate management solutions. The current review will describe both normal and pathologic tricuspid valvular anatomy, the classification of these anatomic substrates of TR, the strengths and limitations of the current guidelines-recommended multi-parametric echocardiographic approach and the role of multi-modality imaging, as well as the role of transcatheter device therapy in the management of the disease.<\/jats:p>","DOI":"10.1093\/ehjci\/jeac009","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T10:33:11Z","timestamp":1641983591000},"page":"913-929","source":"Crossref","is-referenced-by-count":260,"title":["Tricuspid regurgitation: recent advances in understanding pathophysiology, severity grading and outcome"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-9191","authenticated-orcid":false,"given":"Rebecca T","family":"Hahn","sequence":"first","affiliation":[{"name":"Cardiology Department, NewYork-Presbyterian\/Columbia University Medical Center , 177 Fort Washington Avenue, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi P","family":"Badano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Milan , Italy"},{"name":"Department of Cardiological, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp E","family":"Bartko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Vienna , Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-3668","authenticated-orcid":false,"given":"Denisa","family":"Muraru","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Milan , Italy"},{"name":"Department of Cardiological, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, IRCCS Ospedale San Raffaele , Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Ram\u00f3n y Cajal , Madrid , Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-3389","authenticated-orcid":false,"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"Cardiology Department, Universit\u00e9 de Rennes-1 , Rennes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"2022101310260503400_jeac009-B1","first-page":"157","article-title":"Tricuspid regurgitation and long-term clinical outcomes","volume":"21","author":"Chorin","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022101310260503400_jeac009-B2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/CIRCULATIONAHA.118.038946","article-title":"Excess mortality associated with functional tricuspid regurgitation complicating heart failure with reduced ejection fraction","volume":"140","author":"Benfari","year":"2019","journal-title":"Circulation"},{"key":"2022101310260503400_jeac009-B3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pcad.2019.10.009","article-title":"Tricuspid regurgitation is a public health crisis","volume":"62","author":"Enriquez-Sarano","year":"2019","journal-title":"Prog 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