{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:12:28Z","timestamp":1793196748907,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","award":["App000064741"],"award-info":[{"award-number":["App000064741"]}],"id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","award":["App000080404"],"award-info":[{"award-number":["App000080404"]}],"id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","award":["T-2018-17405"],"award-info":[{"award-number":["T-2018-17405"]}],"id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>Moderate aortic stenosis (AS) is associated with an increased risk of adverse events. Because outcomes in patients with AS are ultimately driven by the condition of the left ventricle (LV) and not by the valve, assessment of LV remodelling seems important for risk stratification. This study evaluated the association between different LV remodelling patterns and outcomes in patients with moderate AS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>Patients with moderate AS (aortic valve area 1.0\u20131.5 cm2) were identified and stratified into four groups according to the LV remodelling pattern: normal geometry (NG), concentric remodelling (CR), concentric hypertrophy (CH), or eccentric hypertrophy (EH). Clinical outcomes were defined as all-cause mortality and a composite endpoint of all-cause mortality and aortic valve replacement (AVR). Of 1931 patients with moderate AS (age 73 \u00b1 10 years, 52% men), 344 (18%) had NG, 469 (24%) CR, 698 (36%) CH, and 420 (22%) EH. Patients with CH and EH showed higher 3-year mortality rates (28% and 32%, respectively) when compared with patients with NG (19%) (P &amp;lt; 0.001). After multivariable adjustment, CH remained independently associated with mortality (HR 1.258, 95% CI 1.016\u20131.558; P = 0.035), whereas both CH (HR 1.291, 95% CI 1.088\u20131.532; P = 0.003) and EH (HR 1.217, 95% CI 1.008\u20131.470; P = 0.042) were associated with the composite endpoint of death or AVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion\u2003<\/jats:title>\n                  <jats:p>In patients with moderate AS, those who develop CH already have an increased risk of all-cause mortality. Assessment of the LV remodelling patterns may identify patients at higher risk of adverse events, warranting closer surveillance, and possibly earlier intervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac018","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T12:11:54Z","timestamp":1643199114000},"page":"1326-1335","source":"Crossref","is-referenced-by-count":31,"title":["Left ventricular remodelling patterns in patients with moderate aortic stenosis"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-5498","authenticated-orcid":false,"given":"Jan","family":"Stassen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2 , 2300 RC Leiden, The Netherlands"},{"name":"Department of Cardiology, Jessa Hospital , Hasselt , 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet K","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2 , 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed R","family":"Amanullah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart Centre Singapore , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny Y K","family":"Sin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart Centre Singapore , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zee P","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart Centre Singapore , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan M","family":"Pio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2 , 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-0430","authenticated-orcid":false,"given":"Nicholas W S","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Center Singapore , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-2869","authenticated-orcid":false,"given":"Ching Hui","family":"Sia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Center Singapore , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K F","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Center Singapore , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Keong","family":"Poh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Center Singapore , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saint Francis Hospital, Roslyn , NY , USA"},{"name":"Department of Cardiology, Cardiovascular Research Foundation , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gagnon Cardiovascular Institute, Morristown Medical Center , Morristown, NJ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B","family":"Leon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Columbia University Irving Medical Center\/New York\u2014Presbyterian Hospital, Cardiovascular Research Foundation , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Ajmone","family":"Marsan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2 , 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-2737","authenticated-orcid":false,"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2 , 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen 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