{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:20:00Z","timestamp":1790695200868,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Alexandre Suerman Stipend of the UMC Utrecht"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by ventricular dysfunction and ventricular arrhythmias (VA). Adequate arrhythmic risk assessment is important to prevent sudden cardiac death. We aimed to study the incremental value of strain by feature-tracking cardiac magnetic resonance imaging (FT-CMR) in predicting sustained VA in ARVC patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>CMR images of 132 ARVC patients (43% male, 40.6\u2009\u00b1\u200916.0\u2009years) without prior VA were analysed for global and regional right and left ventricular (RV, LV) strain. Primary outcome was sustained VA during follow-up. We performed multivariable regression assessing strain, in combination with (i) RV ejection fraction (EF); (ii) LVEF; and (iii) the ARVC risk calculator. False discovery rate adjusted P-values were given to correct for multiple comparisons and c-statistics were calculated for each model. During 4.3 (2.0\u20137.9) years of follow-up, 19% of patients experienced sustained VA. Compared to patients without VA, those with VA had significantly reduced RV longitudinal (P\u2009\u2264\u20090.03) and LV circumferential (P\u2009\u2264\u20090.04) strain. In addition, patients with VA had significantly reduced biventricular EF (P\u2009\u2264\u20090.02). After correcting for RVEF, LVEF, and the ARVC risk calculator separately in multivariable analysis, both RV and LV strain lost their significance [hazard ratio 1.03\u20131.18, P\u2009&amp;gt;\u20090.05]. Likewise, while strain improved the c-statistic in combination with RVEF, LVEF, and the ARVC risk calculator separately, this did not reach statistical significance (P\u2009\u2265\u20090.18).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Both RV longitudinal and LV circumferential strain are reduced in ARVC patients with sustained VA during follow-up. However, strain does not have incremental value over RVEF, LVEF, and the ARVC VA risk calculator.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac030","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T12:08:47Z","timestamp":1643458127000},"page":"98-107","source":"Crossref","is-referenced-by-count":38,"title":["Prognostic value of strain by feature-tracking cardiac magnetic resonance in arrhythmogenic right ventricular cardiomyopathy"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-4610","authenticated-orcid":false,"given":"M","family":"Bourfiss","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, 3584 CX Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N H J","family":"Prakken","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Groningen , Hanzeplein 1, 9713 GZ Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"James","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21218 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Planken","sequence":"additional","affiliation":[{"name":"Department of Radiology and nuclear medicine, Amsterdam University Medical Center , Amsterdam, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Boekholdt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center , Amsterdam, Location AMC, Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Ahmetagic","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, 3584 CX Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Tichnell","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21218 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Van der Heijden","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, 3584 CX Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Loh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, 3584 CX Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21218 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Tandri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21218 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21218 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Calkins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21218 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F W","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, 3584 CX Utrecht , The Netherlands"},{"name":"Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London , Gower St, London WC1E 6BT , UK"},{"name":"Health Data Research UK and Institute of Health Informatics, University College London , Gower St, London WC1E 6BT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S L","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins Hospital , 1800 Orleans St, Baltimore, MD 21218 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B K","family":"Velthuis","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, 3584 CX Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S J M","family":"Te Riele","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, 3584 CX Utrecht , The Netherlands"},{"name":"Netherlands Heart Institute, Moreelsepark 1 , 3511 EP Utrecht , The 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