{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:11:48Z","timestamp":1794564708872,"version":"4.9.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Swiss Heart Foundation"},{"DOI":"10.13039\/501100011561","name":"Georg and Bertha Schwyzer-Winiker Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011561","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007252","name":"Baugarten Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007252","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wild Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by progressive fibro-fatty infiltration of the myocardium and associated with adverse cardiovascular (CV) events. This study aims to examine right atrial (RA) deformation in ARVC and understand its association with CV outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>RA strain was determined in 50 patients with definite ARVC, compared with a matched control group of 50 healthy individuals, and analysed for outcome association over a median follow-up duration of 5 years. A subgroup of 30 ARVC patients with normal RA volume (ARVC-N group) was compared with 30 matched controls (Control-N), and the outcome was analysed separately. RA reservoir, conduit, and pump strain were significantly impaired in ARVC vs. control. Similar observations were made in the N-ARVC subgroup. Reservoir strain was associated with an increased risk of atrial arrhythmia (AA) [hazard ratio (HR) 0.88, P\u2009&amp;lt;\u20090.01] and CV events (HR 0.92, P\u2009&amp;lt;\u20090.01). Conduit strain also predicted AA (HR 1.02, P\u2009&amp;lt;\u20090.01), while pump strain predicted CV events (HR 1.09, P\u2009=\u20090.02). Reservoir strain improved the fitness of bivariable models for the association of RV end-diastolic area index, RV fractional area change, and RV global longitudinal strain with CV events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ARVC patients display impaired RA strain even when RA volume is normal. Reservoir and pump strain are associated with an increased risk of CV events. Reservoir strain improved model fitness for the association of RVGLS and other echocardiographic parameters with CV events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac070","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T07:18:43Z","timestamp":1648624723000},"page":"970-978","source":"Crossref","is-referenced-by-count":30,"title":["Right atrial strain and cardiovascular outcome in arrhythmogenic right ventricular cardiomyopathy"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-8913","authenticated-orcid":false,"given":"Shehab","family":"Anwer","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Guastafierro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladina","family":"Erhart","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Akdis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Schuermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neria E","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar","family":"Kuzo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-070X","authenticated-orcid":false,"given":"Alessio","family":"Gasperetti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Brunckhorst","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firat","family":"Duru","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardan M","family":"Saguner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4315-2667","authenticated-orcid":false,"given":"Felix C","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"2022062118002577100_jeac070-B1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/CIRCIMAGING.113.000210","article-title":"Different prognostic value of functional right ventricular parameters in arrhythmogenic right ventricular cardiomyopathy\/dysplasia","volume":"7","author":"Saguner","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2261-15-4","article-title":"Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy\/dysplasia","volume":"15","author":"Saguner","year":"2015","journal-title":"BMC Cardiovasc Disord"},{"key":"2022062118002577100_jeac070-B3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ahj.2020.01.019","article-title":"Clinical predictors of left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy","volume":"223","author":"Akdis","year":"2020","journal-title":"Am Heart J"},{"key":"2022062118002577100_jeac070-B4","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/eurheartj\/ehx011","article-title":"Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy\/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome","volume":"38","author":"Akdis","year":"2017","journal-title":"Eur Heart J"},{"key":"2022062118002577100_jeac070-B5","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the Task Force Criteria","volume":"31","author":"Marcus","year":"2010","journal-title":"Eur Heart J"},{"key":"2022062118002577100_jeac070-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2022062118002577100_jeac070-B7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.echo.2014.11.003","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"28","author":"Voigt","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2022062118002577100_jeac070-B8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/ehjci\/jew229","article-title":"Comprehensive multi-modality imaging approach in arrhythmogenic right ventricular cardiomyopathy (ARVC)\u2014an EACVI expert consensus document","volume":"18","author":"Haugaa","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/ehjci\/jeaa091","article-title":"How to do LA strain","volume":"21","author":"Voigt","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/ehjci\/jey181","article-title":"Prognostic value of left atrial strain in predicting cardiovascular morbidity and mortality in the general population","volume":"20","author":"Modin","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.echo.2019.01.007","article-title":"Low left atrial strain is associated with adverse outcomes in hypertrophic cardiomyopathy patients","volume":"32","author":"Vasquez","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"key":"2022062118002577100_jeac070-B13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/ehjci\/jeaa013","article-title":"Prognostic power of left atrial strain in patients with acute heart failure","volume":"22","author":"Park","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B14","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.echo.2013.07.019","article-title":"Right atrial and ventricular adaptations to training in male Caucasian athletes: an echocardiographic study","volume":"26","author":"Pagourelias","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"2022062118002577100_jeac070-B15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10554-012-0063-z","article-title":"Characterization of right atrial function and dimension in top-level athletes: a speckle tracking study","volume":"29","author":"D\u2019Ascenzi","year":"2013","journal-title":"Int J Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B16","doi-asserted-by":"crossref","first-page":"e006984","DOI":"10.1161\/CIRCIMAGING.117.006984","article-title":"Clinical utility and prognostic value of right atrial function in pulmonary hypertension","volume":"11","author":"Alenezi","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B17","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1253\/circj.CJ-14-0474","article-title":"Clinical role of atrial arrhythmias in patients with arrhythmogenic right ventricular dysplasia","volume":"78","author":"Saguner","year":"2014","journal-title":"Circ J"},{"key":"2022062118002577100_jeac070-B18","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.hrthm.2013.08.032","article-title":"Prevalence of atrial arrhythmias in arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"10","author":"Camm","year":"2013","journal-title":"Heart Rhythm"},{"key":"2022062118002577100_jeac070-B19","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jacc.2004.10.070","article-title":"Echocardiographic findings in patients meeting task force criteria for arrhythmogenic right ventricular dysplasia: new insights from the multidisciplinary study of right ventricular dysplasia","volume":"45","author":"Yoerger","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2022062118002577100_jeac070-B20","doi-asserted-by":"crossref","first-page":"e007344","DOI":"10.1161\/CIRCIMAGING.117.007344","article-title":"Atrial dysfunction in arrhythmogenic right ventricular cardiomyopathy","volume":"11","author":"Zghaib","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022062118002577100_jeac070-B21","doi-asserted-by":"crossref","first-page":"736","DOI":"10.5603\/CJ.a2018.0123","article-title":"Right atrial pathology in arrhythmogenic right ventricular dysplasia","volume":"26","author":"Li","year":"2020","journal-title":"Cardiol J"},{"key":"2022062118002577100_jeac070-B22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jvc.2016.09.001","article-title":"Structural and molecular pathology of the atrium in boxer arrhythmogenic right ventricular cardiomyopathy","volume":"19","author":"Vila","year":"2017","journal-title":"J Vet Cardiol"},{"key":"2022062118002577100_jeac070-B23","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1161\/01.CIR.102.15.1863","article-title":"Spontaneously occurring arrhythmogenic right ventricular cardiomyopathy in the domestic cat: a new animal model similar to the human disease","volume":"102","author":"Fox","year":"2000","journal-title":"Circulation"},{"key":"2022062118002577100_jeac070-B24","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.amjcard.2010.04.031","article-title":"Atrial arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia and ventricular tachycardia","volume":"106","author":"Chu","year":"2010","journal-title":"Am J Cardiol"},{"key":"2022062118002577100_jeac070-B25","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0002-8703(98)70032-8","article-title":"Increased atrial vulnerability in arrhythmogenic right ventricular disease","volume":"135","author":"Brembilla-Perrot","year":"1998","journal-title":"Am Heart J"},{"key":"2022062118002577100_jeac070-B26","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0002-9149(91)90886-P","article-title":"Frequency of supraventricular tachyarrhythmias in arrhythmogenic right ventricular dysplasia","volume":"67","author":"Tonet","year":"1991","journal-title":"Am J Cardiol"},{"key":"2022062118002577100_jeac070-B27","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/jce.13094","article-title":"Influence of genotype on structural atrial abnormalities and atrial fibrillation or flutter in arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"27","author":"Bourfiss","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2022062118002577100_jeac070-B28","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.jacc.2016.09.951","article-title":"Arrhythmogenic right ventricular cardiomyopathy: clinical course and predictors of arrhythmic risk","volume":"68","author":"Mazzanti","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2022062118002577100_jeac070-B29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jelectrocard.2010.08.008","article-title":"Abnormal atrial activation is common in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"44","author":"Platonov","year":"2011","journal-title":"J Electrocardiol"},{"key":"2022062118002577100_jeac070-B30","doi-asserted-by":"crossref","first-page":"16772","DOI":"10.1038\/s41598-017-17117-3","article-title":"Investigation of atrial vortices using a novel right heart model and possible implications for atrial thrombus formation","volume":"7","author":"G\u00fclan","year":"2017","journal-title":"Sci Rep"},{"key":"2022062118002577100_jeac070-B31","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1161\/CIRCULATIONAHA.109.913871","article-title":"Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia","volume":"122","author":"Corrado","year":"2010","journal-title":"Circulation"},{"key":"2022062118002577100_jeac070-B32","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/01.CIR.0000121738.88273.43","article-title":"Implantable cardioverter\/defibrillator therapy in arrhythmogenic right ventricular cardiomyopathy: single-center experience of long-term follow-up and complications in 60 patients","volume":"109","author":"Wichter","year":"2004","journal-title":"Circulation"},{"key":"2022062118002577100_jeac070-B33","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.jacc.2004.01.030","article-title":"Implantable cardioverter-defibrillators in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"43","author":"Roguin","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2022062118002577100_jeac070-B34","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/S0735-1097(00)00997-9","article-title":"Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy","volume":"36","author":"Nava","year":"2000","journal-title":"J Am Coll Cardiol"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/23\/7\/970\/44157344\/jeac070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/23\/7\/970\/44157344\/jeac070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T14:01:20Z","timestamp":1655820080000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/23\/7\/970\/6576512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,5,2]]},"published-print":{"date-parts":[[2022,6,21]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jeac070","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,5,2]]}}}