{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:37:38Z","timestamp":1793813858056,"version":"4.6.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Multisystem inflammatory syndrome in children (MIS-C) with cardiovascular manifestations are frequent. However, there is lacking evidence regarding cardiological follow-up of this cohort of patients. The aim of our study was to describe the early and mid-term cardiac abnormalities assessed by standard and speckle-tracking echocardiography (STE), and cardiac MRI (CMR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We enrolled 32 patients (21 male, 11 female), mean age 8.25\u2009\u00b1\u20094years, with diagnosis of MIS-C. During admission, all children underwent TTE, STE with analysis of left ventricle global longitudinal strain (GLS) and CMR. Patients underwent cardiological evaluation at 2 (T1) and 6 months (T2) after discharge. Cardiac MRI was repeated at 6 months after discharge. Mean left ventricular ejection fraction (LVEF) at baseline was 58.8\u2009\u00b1\u200910% with 10 patients (31%) below 55%. Speckle-tracking echocardiography showed reduced mean LV GLS (\u221217.4\u2009\u00b1\u20094%). On CMR, late gadolinium enhancement (LGE) with non-ischaemic pattern was evident in 8 of 23 patients (35%). Follow-up data showed rapid improvement of LVEF at T1 (62.5\u2009\u00b1\u20097.5 vs. 58.8\u2009\u00b1\u200910.6%, P-value 0.044) with only three patients (10%) below\u2009\u2264\u200955% at T1. Left ventricular (LV) GLS remained impaired at T1 (\u221217.2\u2009\u00b1\u20092.7 vs.\u221217.4\u2009\u00b1\u20094, P-value 0.71) and significantly improved at T2 (\u221219\u2009\u00b1\u20092.6% vs. \u221217.4\u2009\u00b1\u20094%, P-value 0.009). LV GLS was impaired (&amp;gt;\u221218%) in 53% of patients at baseline and T1, whereas only 13% showed persistent LV GLS reduction at T2. Follow-up CMR showed LGE persistence in 33.4% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early cardiac involvement significantly improves during follow-up of MIS-C patients. However, subclinical myocardial dysfunction seems to be still detectable after 6 months of follow-up in a not negligible proportion of them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac096","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T15:16:57Z","timestamp":1652195817000},"page":"1066-1074","source":"Crossref","is-referenced-by-count":43,"title":["Evolution of echocardiographic and cardiac magnetic resonance imaging abnormalities during follow-up in patients with multisystem inflammatory syndrome in children"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-2292","authenticated-orcid":false,"given":"D","family":"Sirico","sequence":"first","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Basso","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sabatino","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Reffo","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Biffanti","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cerutti","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Castaldi","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Zulian","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Department for Women's and Children's Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Da Dalt","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit, Department for Women's and Children's Health, University Hospital of Padova , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Di Salvo","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Department for Women's and Children\u2019s Health, University Hospital of Padova , Via Nicol\u00f2 Giustiniani 2, 35128 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"2022072121185773800_jeac096-B1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1001\/jamapediatrics.2020.1948","article-title":"Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and canadian pediatric intensive care Units","volume":"174","author":"Shekerdemian","year":"2020","journal-title":"JAMA Pediatr"},{"key":"2022072121185773800_jeac096-B2","first-page":"e201346","article-title":"Screening and severity of coronavirus disease 2019 (COVID-19) in children in madrid, spain","author":"Tagarro","year":"2020","journal-title":"JAMA Pediatr"},{"key":"2022072121185773800_jeac096-B3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1056\/NEJMc2007617","article-title":"Children with Covid-19 in pediatric emergency departments in Italy","volume":"383","author":"Parri","year":"2020;","journal-title":"N Engl J Med"},{"key":"2022072121185773800_jeac096-B4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.46376\/IJMR\/1.3.2020.97-102","article-title":"Multi system inflammatory syndrome in children and adolescents temporally related to COVID-19","volume":"1","author":"Pawar","year":"2020","journal-title":"GFNPSS-Int J Multidiscip Res"},{"key":"2022072121185773800_jeac096-B5","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","article-title":"Hyperinflammatory shock in children during COVID-19 pandemic","volume":"395","author":"Riphagen","year":"2020","journal-title":"Lancet"},{"key":"2022072121185773800_jeac096-B6","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1148\/radiol.2020202543","article-title":"Spectrum of imaging findings at chest radiography, US, CT, and MRI in multisystem inflammatory syndrome in children associated with COVID-19","volume":"298","author":"Hameed","year":"2021","journal-title":"Radiology"},{"key":"2022072121185773800_jeac096-B7","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.cell.2020.09.034","article-title":"Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C)","volume":"183","author":"Gruber","year":"2020","journal-title":"Cell"},{"key":"2022072121185773800_jeac096-B8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.120.050065","article-title":"Acute cardiovascular manifestations in 286 children with multisystem inflammatory syndrome associated with COVID-19 infection in Europe","volume":"143","author":"Valverde","year":"2021","journal-title":"Circulation"},{"key":"2022072121185773800_jeac096-B9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3345\/cep.2020.01900","article-title":"Clinical features, diagnosis, and outcomes of multisystem inflammatory syndrome in children associated with coronavirus disease 2019","volume":"64","author":"Kwak","year":"2021","journal-title":"Clin Exp Pediatr"},{"key":"2022072121185773800_jeac096-B10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00431-020-03766-6","article-title":"Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach","volume":"180","author":"Sperotto","year":"2021","journal-title":"Eur J Pediatr"},{"key":"2022072121185773800_jeac096-B11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1161\/CIRCULATIONAHA.120.049836","article-title":"Review of cardiac involvement in multisystem inflammatory syndrome in children","volume":"143","author":"Alsaied","year":"2021","journal-title":"Circulation"},{"key":"2022072121185773800_jeac096-B12","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.jacc.2020.08.056","article-title":"Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States","volume":"76","author":"Matsubara","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2022072121185773800_jeac096-B13","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jcmg.2021.01.035","article-title":"Short-Term sequelae of multisystem inflammatory syndrome in children assessed by CMR","volume":"14","author":"Bermejo","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022072121185773800_jeac096-B14","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.3390\/jcm10153360","article-title":"Early echocardiographic and cardiac mri findings in multisystem inflammatory syndrome in children","volume":"10","author":"Sirico","year":"2021","journal-title":"J Clin Med"},{"key":"2022072121185773800_jeac096-B15","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ehjci\/jeaa212","article-title":"Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19","volume":"22","author":"Theocharis","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022072121185773800_jeac096-B16","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1002\/art.41616","article-title":"American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2","volume":"73","author":"Henderson","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"2022072121185773800_jeac096-B17","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.jcmg.2020.06.001","article-title":"Multimodality cardiovascular imaging in the midst of the COVID-19 pandemic: ramping up safely to a new ormal","volume":"13","author":"Zoghbi","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022072121185773800_jeac096-B18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2459\/JCM.0000000000000990","article-title":"Cardiac imaging in congenital heart disease during the coronavirus disease-2019 pandemic: recommendations from the Working Group on Congenital Heart Disease of the Italian Society of Cardiology","volume":"21","author":"Sirico","year":"2020","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2022072121185773800_jeac096-B19","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"2022072121185773800_jeac096-B20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijcard.2018.10.046","article-title":"Prognostic value of echocardiographic parameters in pediatric patients with Ebstein\u2019s anomaly","volume":"278","author":"Prota","year":"2019","journal-title":"Int J Cardiol"},{"key":"2022072121185773800_jeac096-B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjci\/jeu184","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"16","author":"Voigt","year":"2015","journal-title":"Eur Hear journal Cardiovasc Imaging"},{"key":"2022072121185773800_jeac096-B22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2459\/JCM.0000000000000316","article-title":"Left ventricular mechanics after arterial switch operation: a speckle-tracking echocardiography study","volume":"17","author":"Di Salvo","year":"2016","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2022072121185773800_jeac096-B23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.echo.2015.11.016","article-title":"Reference ranges of left ventricular strain measures by two-dimensional speckle-tracking echocardiography in children: a systematic review and meta-analysis","volume":"29","author":"Levy","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"issue":"Suppl. 1","key":"2022072121185773800_jeac096-B24","article-title":"Left ventricular longitudinal strain alterations in asymptomatic or mildly symptomatic paediatric patients with SARS-CoV-2 infection","volume":"22","author":"Sirico","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022072121185773800_jeac096-B25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000447961","article-title":"Left ventricular mechanics in patients with abnormal origin of the left main coronary artery from the pulmonary trunk late after successful repair","volume":"136","author":"Di Salvo","year":"2017","journal-title":"Cardiology"},{"key":"2022072121185773800_jeac096-B26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2217\/fca-2020-0121","article-title":"Abnormal left ventricular global longitudinal strain by speckle tracking echocardiography in COVID-19 patients","volume":"17","author":"Croft","year":"2021","journal-title":"Future Cardiol"},{"key":"2022072121185773800_jeac096-B27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jcmg.2017.11.017","article-title":"Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction","volume":"11","author":"Potter","year":"2018","journal-title":"JACC. Cardiovasc. Imaging"},{"key":"2022072121185773800_jeac096-B28","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1001\/jamacardio.2019.2952","article-title":"Assessment of prognostic value of left ventricular global longitudinal strain for early prediction of chemotherapy-induced cardiotoxicity: a systematic review and meta-analysis","volume":"4","author":"Oikonomou","year":"2019","journal-title":"JAMA Cardiol"},{"key":"2022072121185773800_jeac096-B29","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/echo.14998","article-title":"LV-GLS in congenital heart disease, time to go beyond ejection fraction","volume":"38","author":"Castaldi","year":"2021","journal-title":"Echocardiography"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/23\/8\/1066\/45045893\/jeac096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/23\/8\/1066\/45045893\/jeac096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T17:19:35Z","timestamp":1658423975000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/23\/8\/1066\/6594069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,5,27]]},"published-print":{"date-parts":[[2022,7,21]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jeac096","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,5,27]]}}}