{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:47:57Z","timestamp":1778165277954,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["RC 2017 R659\/17-CCM698"],"award-info":[{"award-number":["RC 2017 R659\/17-CCM698"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment of RV function is challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) is the gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate the prognostic value of CMR-derived RV systolic function in a large cohort of HF with reduced ejection fraction (HFrEF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography (n = 2449). RVSD was defined as RV ejection fraction (RVEF) &amp;lt;45%. Kaplan\u2013Meier curves and cox regression were used to investigate the association between RVSD and all-cause mortality (ACM). Mean age was 59.8 \u00b1 14.0 years, 42.0% were female, and mean left ventricular ejection fraction (LVEF) was 34.0 \u00b1 10.8. Median follow-up was 959 days (interquartile range: 560\u20131590). RVSD was present in 936 (38.2%) and was an independent predictor of ACM (adjusted hazard ratio = 1.44; 95% CI [1.09\u20131.91]; P = 0.01). On subgroup analyses, the prognostic value of RVSD was more pronounced in NYHA I\/II than in NYHA III\/IV, in LVEF &amp;lt;35% than in LVEF \u226535%, and in patients with renal dysfunction when compared to those with normal renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RV systolic dysfunction is an independent predictor of ACM in HFrEF, with a more pronounced prognostic value in select subgroups, likely reflecting the importance of RVSD in the early stages of HF progression.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjci\/jeac124","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T13:46:55Z","timestamp":1657115215000},"page":"472-482","source":"Crossref","is-referenced-by-count":8,"title":["Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy"],"prefix":"10.1093","volume":"24","author":[{"given":"Subhi J","family":"Al\u2019Aref","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences , Little Rock, AR , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-5415","authenticated-orcid":false,"given":"Ahmed M","family":"Altibi","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health and Science University , Portland, OR , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1817-7862","authenticated-orcid":false,"given":"Abdallah","family":"Malkawi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences , Little Rock, AR , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munthir","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences , Little Rock, AR , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lohendran","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Heart Centre , Singapore , Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-6526","authenticated-orcid":false,"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health and Science University , Portland, OR , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hind","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health and Science University , Portland, OR , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-1809","authenticated-orcid":false,"given":"Raffaele","family":"Abete","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico di Monza , Monza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Andreini","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS, University of Milan , Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Aquaro","sequence":"additional","affiliation":[{"name":"U.O.C. 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