{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:30:47Z","timestamp":1787430647513,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS36286"],"award-info":[{"award-number":["R01 NS36286"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS29993"],"award-info":[{"award-number":["R01 NS29993"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Heart disease is associated with an increased risk for ischaemic stroke. However, the predictive value of reduced left ventricular ejection fraction (LVEF) for stroke is controversial and only observed in patients with severe reduction. LV global longitudinal strain (LV GLS) can detect subclinical LV systolic impairment when LVEF is normal. We investigated the prognostic role of LV GLS for incident stroke in a predominantly elderly cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Two-dimensional echocardiography with speckle tracking was performed in the Cardiac Abnormalities and Brain Lesions (CABL) study. Among 708 stroke-free participants (mean age 71.4 \u00b1 9.4 years, 60.9% women), abnormal LV GLS (&amp;gt;\u221214.7%: 95% percentile of the subgroup without risk factors) was detected in 133 (18.8%). During a mean follow-up of 10.8 \u00b1 3.9 years, 47 participants (6.6%) experienced an ischaemic stroke (26 cardioembolic or cryptogenic, 21 other subtypes). The cumulative incidence of ischaemic stroke was significantly higher in participants with abnormal LV GLS than with normal LV GLS (P &amp;lt; 0.001). In multivariate stepwise logistic regression analysis, abnormal LV GLS was associated with ischaemic stroke independently of cardiovascular risk factors including LVEF, LV mass, left atrial volume, subclinical cerebrovascular disease at baseline, and incident atrial fibrillation [hazard ratio (HR): 2.69, 95% confidence interval (CI): 1.47\u20134.92; P = 0.001]. Abnormal LV GLS independently predicted cardioembolic or cryptogenic stroke (adjusted HR: 3.57, 95% CI: 1.51\u20138.43; P = 0.004) but not other subtypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LV GLS was a strong independent predictor of ischaemic stroke in a predominantly elderly stroke-free cohort. Our findings provide insights into the brain\u2013heart interaction and may help improve stroke primary prevention strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac145","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T14:40:47Z","timestamp":1659019247000},"page":"522-531","source":"Crossref","is-referenced-by-count":12,"title":["Subclinical left ventricular systolic dysfunction and incident stroke in the elderly: long-term findings from Cardiovascular Abnormalities and Brain Lesions"],"prefix":"10.1093","volume":"24","author":[{"given":"Yuriko","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhezhen","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazato","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Mannina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S V","family":"Elkind","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Yoshita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton B","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Columbia university Irving Medical Center , 630 W 168th St, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph 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