{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:14:48Z","timestamp":1782422088501,"version":"3.54.5"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Myocardial perfusion imaging with 82-rubidium positron emission tomography (82Rb-PET) is increasingly used to assess stable coronary artery disease (CAD). We aimed to evaluate the prognostic value of 82Rb-PET-derived parameters in patients with symptoms suggestive of CAD but no significant reversible or irreversible perfusion defects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Among 3726 consecutive patients suspected of stable CAD who underwent 82Rb-PET between January 2018 and August 2020, 2175 had no regional perfusion defects. Among these patients, we studied the association of 82Rb-PET-derived parameters with a composite endpoint of all-cause mortality, hospitalization for unstable angina pectoris, acute myocardial infarction, heart failure, or ischaemic stroke. During a median follow up of 1.7 years (interquartile range 1.1\u20132.5 years), there were 148 endpoints. Myocardial blood flow (MBF) reserve (MFR), MBF during stress, left ventricular ejection fraction (LVEF), LVEF-reserve, heart rate reserve, and Ca score were associated with adverse outcomes. In multivariable Cox model adjusted for patient and 82Rb-PET characteristics, MFR &amp;lt; 2 (hazard ratio (HR) 1.75, 95% confidence interval (CI) 1.24\u20132.48), LVEF (HR 1.38 per 10% decrease, 95% CI 1.24\u20131.54), and LVEF-reserve (HR 1.19 per 5% decrease, 95% CI 1.07\u20131.31) were significant predictors of endpoints. Results were consistent in subgroups defined by gender, history of ischaemic heart disease, low LVEF, and atrial fibrillation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>MFR, LVEF, and LVEF-reserve derived from 82Rb-PET provide prognostic information on cardiovascular outcomes in patients with no perfusion defects. This may aid in identifying patients at risk and might provide an opportunity for preventive interventions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac217","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T15:13:19Z","timestamp":1668697999000},"page":"212-222","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-353X","authenticated-orcid":false,"given":"Maira","family":"Rauf","sequence":"first","affiliation":[{"name":"Department of Cardiology, Bispebjerg Frederiksberg Hospital , Bispebjerg Bakke 23, 2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim W","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bispebjerg Frederiksberg Hospital , Bispebjerg Bakke 23, 2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Galatius","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bispebjerg Frederiksberg Hospital , Bispebjerg Bakke 23, 2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Wiinberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Frederiksberg Hospital , Bispebjerg Bakke 23, 2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Scouborg","family":"Brinth","sequence":"additional","affiliation":[{"name":"Department of Imaging and Radiology, Copenhagen University Hospital\u2014North Zealand , Dyrehavevej 29, 3400 Hiller\u00f8d , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"H\u00f8jstrup","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bispebjerg Frederiksberg Hospital , Bispebjerg Bakke 23, 2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Talleruphuus","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Frederiksberg Hospital , Bispebjerg Bakke 23, 2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Prescott","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bispebjerg Frederiksberg Hospital , Bispebjerg Bakke 23, 2400 Copenhagen , 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