{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:24:30Z","timestamp":1793942670405,"version":"4.8.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To study if any qualitative or quantitative optical coherence tomography (OCT) variables in combination with thin cap fibroatheroma (TCFA) patients could improve the identification of lesions at risk for future major adverse cardiac events (MACEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From the combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT-FFR) trial database (NCT02989740), we performed a detailed assessment OCT qualitative and quantitative variables in TCFA carrying diabetes mellitus (DM) patients with vs. without MACE during follow-up. MACEs were defined as a composite of cardiac death, target vessel myocardial infarction, clinically driven target lesion revascularization, and hospitalization for unstable angina. From the 390 fractional flow reserve (FFR)-negative DM patients, 98 (25.2%) had \u22651 OCT-detected TCFA, of which 13 (13.3%) had MACE and 85 (86.7%) were event-free (non-MACE). The baseline characteristics were similar between both groups; however, a smaller minimal lumen area (MLA) and lower mean FFR value were observed in MACE group (1.80 vs. 2.50 mm2, P = 0.01, and 0.85 vs. 0.89, P = 0.02, respectively). Prevalence of healed plaque (HP) was higher in the MACE group (53.85 vs. 21.18%, P = 0.01). TCFA were predominantly located proximal to the MLA. TCFA area was smaller in the MACE group, while no difference was observed regarding the lesion area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within TCFA carrying patients, a smaller MLA, lower FFR values, and TCFA location adjacent to a HP were associated with future MACE. Carpet-like measured lesion area surface was similar, while the TCFA area was smaller in the MACE arm, and predominantly located proximal to the MLA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac218","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:33:20Z","timestamp":1666200800000},"page":"687-693","source":"Crossref","is-referenced-by-count":13,"title":["Morphological characteristics of lesions with thin cap fibroatheroma\u2014a substudy from the COMBINE (OCT-FFR) trial"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-8752","authenticated-orcid":false,"given":"Magda","family":"Roleder-Dylewska","sequence":"first","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases, Medical University of Silesia , ul.Zio\u0142owa 45, Katowice, 40-635 , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Gasior","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases, Medical University of Silesia , ul.Zio\u0142owa 45, Katowice, 40-635 , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias M","family":"Hommels","sequence":"additional","affiliation":[{"name":"Isala Hartcentrum , Zwolle , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Roleder","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases, Medical University of Silesia , ul.Zio\u0142owa 45, Katowice, 40-635 , Poland"},{"name":"Department of Cardiology, Hospital Wroclaw , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-8821","authenticated-orcid":false,"given":"Balasz","family":"Berta","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University , Budapest , Hungary"},{"name":"Isala Hartcentrum , Zwolle , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Ying","family":"Ang","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore , 5 Hospital Drive, Singapore 169609 , Singapore"},{"name":"Department of Biomedical Engineering , 4 Engineering Drive 3, Singapore 117583 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaryl Chen Koon","family":"Ng","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore , 5 Hospital Drive, Singapore 169609 , Singapore"},{"name":"Department of Biomedical Engineering , 4 Engineering Drive 3, Singapore 117583 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renicus S","family":"Hermanides","sequence":"additional","affiliation":[{"name":"Isala Hartcentrum , Zwolle , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-0736","authenticated-orcid":false,"given":"Enrico","family":"Fabris","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, University of Trieste , Trieste , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J J","family":"IJsselmuiden","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amphia Ziekenhuis , Breda , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Kauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Albert Schweitzer Ziekenhuis , Dordrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-2511","authenticated-orcid":false,"given":"Fernando","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario La Princesa , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"von Birgelen","sequence":"additional","affiliation":[{"name":"Thoraxcentrum Twente, Medisch Spectrum Twente , Enschede , The Netherlands"},{"name":"Technical Medical Centre, University of Twente , Enschede , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-0112","authenticated-orcid":false,"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-8318","authenticated-orcid":false,"given":"Cyril","family":"Camaro","sequence":"additional","affiliation":[{"name":"University Medical Center Radboudumc , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Beaumont Hospital , Dublin , Ireland"},{"name":"Royal College of Surgeons in Ireland , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-6613","authenticated-orcid":false,"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"INCCI- Haertz Zenter , Luxembourg , Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Magro","sequence":"additional","affiliation":[{"name":"Tweesteden Ziekenhuis , Tilburg , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Nef","sequence":"additional","affiliation":[{"name":"Department Cardiology and Angiology, University of Giessen; German Centre for Cardiovascular Research (DZHK) , Gie\u00dfen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Reith","sequence":"additional","affiliation":[{"name":"Uniklinik RWTH , Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Malinowski","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Telemedicine, Faculty of Medicine, Jagiellonian University Medical College , Krak\u00f3w , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-2899","authenticated-orcid":false,"given":"Giuseppe","family":"De Luca","sequence":"additional","affiliation":[{"name":"Eastern Piedmont University , Novara , 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