{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:12:09Z","timestamp":1780571529263,"version":"3.54.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate whether left arterial reservoir strain (LASr) could predict new-onset atrial fibrillation (NOAF) in patients with light-chain-type cardiac amyloidosis (ALCA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This study enrolled 427 patients with CA from two tertiary centres between 2005 and 2019. LASr was measured using a vendor-independent analysis programme. The primary outcome was NOAF. A total of 287 patients with ALCA were included [median age 63.0 (56.0\u201370.0) years, 53.3% male]. The median LASr was 13.9% (10.5\u201320.8%). During the median follow-up of 0.85 years, AF occurred in 34 patients (11.8%). In the receiver operating characteristics curve analysis, the optimal cut-off of LASr for predicting NOAF was 14.4%. Patients with LASr \u226414.4% had a higher risk of NOAF than those with LASr &amp;gt;14.4% (18.1% vs. 5.1%, P &amp;lt; 0.010). In the multivariate analysis adjusting for confounding factors, including left arterial volume index and left ventricular global longitudinal strain (LV-GLS), higher LASr (%) was independently associated with lower risk for NOAF [adjusted hazard ratio (aHR): 0.936, 95% confidence interval (95% CI): 0.879\u20130.997, P = 0.039]. Furthermore, LASr \u226414.4% was an independent predictor for NOAF (aHR: 3.370, 95% CI: 1.337\u20138.492, P = 0.010). This remained true after accounting for all-cause death as a competing risk. Compared with Model 1 (LV-GLS) and Model 2 (LV-GLS plus LAVI), Model 3, including LASr showed a better reclassification ability for predicting NOAF (net reclassification index = 0.735, P &amp;lt; 0.001 compared with Model 1; net reclassification index = 0.514, P = 0.003 compared with Model 2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LASr was an independent predictor of NOAF in patients with ALCA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac269","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T01:45:10Z","timestamp":1673660710000},"page":"751-758","source":"Crossref","is-referenced-by-count":17,"title":["Left atrial reservoir strain as a novel predictor of new-onset atrial fibrillation in light-chain-type cardiac amyloidosis"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-855X","authenticated-orcid":false,"given":"You-Jung","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital , 148 Gurodong-ro, Guro-dong, Guro-gu Seoul 08308 , Republic of Korea"},{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 103 Daehak-ro, Jongno-gu Seoul 03080 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-Ro, Gangnam-gu, Seoul 06351 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea-Min","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 103 Daehak-ro, Jongno-gu Seoul 03080 , Republic of Korea"},{"name":"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital , 101, Daehak-ro Jongno-gu, Seoul 03080 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-0705","authenticated-orcid":false,"given":"Hyun-Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 103 Daehak-ro, Jongno-gu Seoul 03080 , Republic of Korea"},{"name":"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital , 101, Daehak-ro Jongno-gu, Seoul 03080 , Republic of 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Jongno-gu, Seoul 03080 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-A","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-Ro, Gangnam-gu, Seoul 06351 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 103 Daehak-ro, Jongno-gu Seoul 03080 , Republic of Korea"},{"name":"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital , 101, Daehak-ro Jongno-gu, Seoul 03080 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-5611","authenticated-orcid":false,"given":"Eun-Seok","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-Ro, Gangnam-gu, Seoul 06351 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae K","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-Ro, Gangnam-gu, Seoul 06351 , Republic of Korea"},{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 201 W. 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