{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:32:59Z","timestamp":1790357579739,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Edinburgh Clinical Research Facilities"},{"name":"Edinburgh Imaging facility"},{"name":"National Health Service Research Scotland"},{"name":"National Health Service Lothian Health Board"},{"name":"Romanian Society of Cardiology Research","award":["266\/8.06.2021"],"award-info":[{"award-number":["266\/8.06.2021"]}]},{"name":"University of Edinburgh Centre of Research Excellence Award"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/ICRF\/20\/26002"],"award-info":[{"award-number":["FS\/ICRF\/20\/26002"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/09\/002"],"award-info":[{"award-number":["CH\/09\/002"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/16\/10\/32375"],"award-info":[{"award-number":["RG\/16\/10\/32375"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/18\/5\/34216"],"award-info":[{"award-number":["RE\/18\/5\/34216"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/SCRF\/21\/32010"],"award-info":[{"award-number":["FS\/SCRF\/21\/32010"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scottish Imaging Network"},{"DOI":"10.13039\/501100003246","name":"Netherlands Organization for Scientific Research","doi-asserted-by":"publisher","award":["91619098"],"award-info":[{"award-number":["91619098"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"publisher","award":["03-004-2021-T045"],"award-info":[{"award-number":["03-004-2021-T045"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT103782AIA"],"award-info":[{"award-number":["WT103782AIA"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000282","name":"Sir Jules Thorn Award","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000282","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomedical Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Bioprosthetic aortic valve degeneration demonstrates pathological similarities to aortic stenosis. Lipoprotein(a) [Lp(a)] is a well-recognized risk factor for incident aortic stenosis and disease progression. The aim of this study is to investigate whether serum Lp(a) concentrations are associated with bioprosthetic aortic valve degeneration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In a post hoc analysis of a prospective multimodality imaging study (NCT02304276), serum Lp(a) concentrations, echocardiography, contrast-enhanced computed tomography (CT) angiography, and 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) were assessed in patients with bioprosthetic aortic valves. Patients were also followed up for 2 years with serial echocardiography. Serum Lp(a) concentrations [median 19.9 (8.4\u201376.4) mg\/dL] were available in 97 participants (mean age 75 \u00b1 7 years, 54% men). There were no baseline differences across the tertiles of serum Lp(a) concentrations for disease severity assessed by echocardiography [median peak aortic valve velocity: highest tertile 2.5 (2.3\u20132.9) m\/s vs. lower tertiles 2.7 (2.4\u20133.0) m\/s, P = 0.204], or valve degeneration on CT angiography (highest tertile n = 8 vs. lower tertiles n = 12, P = 0.552) and 18F-NaF PET (median tissue-to-background ratio: highest tertile 1.13 (1.05\u20131.41) vs. lower tertiles 1.17 (1.06\u20131.53), P = 0.889]. After 2 years of follow-up, there were no differences in annualized change in bioprosthetic hemodynamic progression [change in peak aortic valve velocity: highest tertile [0.0 (\u22120.1\u20130.2) m\/s\/year vs. lower tertiles 0.1 (0.0\u20130.2) m\/s\/year, P = 0.528] or the development of structural valve degeneration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Serum lipoprotein(a) concentrations do not appear to be a major determinant or mediator of bioprosthetic aortic valve degeneration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeac274","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T15:40:08Z","timestamp":1674229208000},"page":"759-767","source":"Crossref","is-referenced-by-count":20,"title":["Serum lipoprotein(a) and bioprosthetic aortic valve degeneration"],"prefix":"10.1093","volume":"24","author":[{"given":"Simona B","family":"Botezatu","sequence":"first","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, Cardiology Department , Euroecolab, 258 Fundeni Road, District 2, 022238, Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Tzolos","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105, Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R G","family":"Cartlidge","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Kwiecinski","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Angiology, Institute of Cardiology , Alpejska 42 04-628, Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K","family":"Barton","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Yu","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C","family":"Williams","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J R","family":"van Beek","sequence":"additional","affiliation":[{"name":"Edinburgh Imaging, Queen's Medical Research Institute, University of Edinburgh , 47 Little France Crescent, EH16 4TJ, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"White","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-6614","authenticated-orcid":false,"given":"Jeffrey","family":"Kroon","sequence":"additional","affiliation":[{"name":"Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105, Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr J","family":"Slomka","sequence":"additional","affiliation":[{"name":"Division of Artificial Intelligence in Medicine, Department of Medicine, Cedars-Sinai Medical Center , 8700 Beverly Blvd, CA 90048 Los Angeles, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan A","family":"Popescu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, Cardiology Department , Euroecolab, 258 Fundeni Road, District 2, 022238, Bucharest , Romania"},{"name":"Emergency Institute for Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu\u201d, Cardiology Department , 258 Fundeni Road, District 2, 022238, Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7971-4628","authenticated-orcid":false,"given":"David E","family":"Newby","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-6260","authenticated-orcid":false,"given":"Erik S G","family":"Stroes","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105, Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang H","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105, Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-5917","authenticated-orcid":false,"given":"Marc R","family":"Dweck","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Chancellor's Building, Little France Crescent, EH16 4SB, Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"2023053100335289000_jeac274-B1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jacc.2018.04.064","article-title":"Hemodynamic deterioration of surgically implanted bioprosthetic aortic valves","volume":"72","author":"Salaun","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2362.2009.02132.x","article-title":"Lipid-mediated inflammation and degeneration of bioprosthetic heart valves","volume":"39","author":"Shetty","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"2023053100335289000_jeac274-B3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-5223(03)00131-4","article-title":"Hancock II bioprosthesis: a glance at the microscope in mid-long-term explants","volume":"126","author":"Bottio","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023053100335289000_jeac274-B4","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.3390\/ijms21207434","article-title":"Ultrastructural pathology of atherosclerosis, calcific aortic valve disease, and bioprosthetic heart valve degeneration: commonalities and differences","volume":"21","author":"Kostyunin","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2023053100335289000_jeac274-B5","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jacc.2018.12.056","article-title":"Detection and prediction of bioprosthetic aortic valve degeneration","volume":"73","author":"Cartlidge","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B6","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1161\/CIRCULATIONAHA.121.056891","article-title":"Native aortic valve disease progression and bioprosthetic valve degeneration in patients with transcatheter aortic valve implantation","volume":"144","author":"Kwiecinski","year":"2021","journal-title":"Circulation"},{"key":"2023053100335289000_jeac274-B7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jacl.2019.04.010","article-title":"Use of lipoprotein(a) in clinical practice: a biomarker whose time has come. A scientific statement from the national lipid association","volume":"13","author":"Wilson","year":"2019","journal-title":"J Clin Lipidol"},{"key":"2023053100335289000_jeac274-B8","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/eurheartj\/ehx033","article-title":"Lipoprotein(a): the revenant","volume":"38","author":"Gencer","year":"2017","journal-title":"Eur Heart J"},{"key":"2023053100335289000_jeac274-B9","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.jacc.2019.01.070","article-title":"Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis","volume":"73","author":"Zheng","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cjco.2019.03.004","article-title":"Lipoprotein(a), oxidized phospholipids, and aortic valve microcalcification assessed by 18F-sodium fluoride positron emission tomography and computed tomography","volume":"1","author":"Despr\u00e9s","year":"2019","journal-title":"CJC Open"},{"key":"2023053100335289000_jeac274-B11","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1001\/jamacardio.2018.3798","article-title":"Association of mild to moderate aortic ValveStenosis progression with higher lipoprotein(a) and oxidized phospholipid levels: secondary analysis of a randomized clinical trial","volume":"3","author":"Capoulade","year":"2018","journal-title":"JAMA Cardiol"},{"key":"2023053100335289000_jeac274-B12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"2023053100335289000_jeac274-B13","doi-asserted-by":"crossref","first-page":"e00218","DOI":"10.1016\/j.plabm.2021.e00218","article-title":"Performance evaluation of five lipoprotein(a) immunoassays on the roche cobas c501 chemistry analyzer","volume":"25","author":"Wyness","year":"2021","journal-title":"Pract Lab Med"},{"key":"2023053100335289000_jeac274-B14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/heartjnl-2021-319804","article-title":"Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis","volume":"108","author":"Kaiser","year":"2022","journal-title":"Heart"},{"key":"2023053100335289000_jeac274-B15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.echo.2009.07.013","article-title":"Recommendations for evaluation of prosthetic valves with echocardiography and Doppler ultrasound","volume":"22","author":"Zoghbi","year":"2009","journal-title":"J Am Soc Echocardiog"},{"key":"2023053100335289000_jeac274-B16","first-page":"589","article-title":"Recommendations for the imaging assessment of prosthetic heart valves: a report from the European association of cardiovascular imaging","volume":"17","author":"Lancellotti","year":"2016","journal-title":"Eur Heart J-Card Img"},{"key":"2023053100335289000_jeac274-B17","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1509233","article-title":"Possible subclinical leaflet thrombosis in bioprosthetic aortic valves","volume":"373","author":"Makkar","year":"2015","journal-title":"N Engl J Med"},{"key":"2023053100335289000_jeac274-B18","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1016\/j.jacc.2020.03.022","article-title":"Evolut low risk LTI substudy investigators. Bioprosthetic aortic valve leaflet thickening in the evolut low risk sub-study","volume":"75","author":"Blanke","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B19","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/ehjci\/jev343","article-title":"Calcium distribution patterns of the aortic valve as a risk factor for the need of permanent pacemaker implantation after transcatheter aortic valve implantation","volume":"17","author":"Fujita","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2023053100335289000_jeac274-B20","doi-asserted-by":"crossref","first-page":"e005131","DOI":"10.1161\/CIRCIMAGING.116.005131","article-title":"Optimization and reproducibility of aortic valve 18f-fluoride positron emission tomography in patients with aortic stenosis","volume":"9","author":"Pawade","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"2023053100335289000_jeac274-B21","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s12350-018-01542-6","article-title":"Analytical quantification of aortic valve 18F-sodium fluoride PET uptake","volume":"27","author":"Massera","year":"2020","journal-title":"J Nucl Cardiol"},{"key":"2023053100335289000_jeac274-B22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.111.051052","article-title":"Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis","volume":"125","author":"Dweck","year":"2012","journal-title":"Circulation"},{"key":"2023053100335289000_jeac274-B23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.117.030729","article-title":"Standardized definition of structural valve degeneration for surgical and transcatheter bioprosthetic valves","volume":"137","author":"Dvir","year":"2018","journal-title":"Circulation"},{"key":"2023053100335289000_jeac274-B24","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/ejcts\/ezx244","article-title":"Standardized definitions of structural deterioration and valve failure in assessing long-term durability of transcatheter and surgical aortic bioprosthetic valves: a consensus statement from the European association of percutaneous cardiovascular interventions (EAPCI) endorsed by the European society of cardiology (ESC) and the European association for cardio-thoracic surgery (EACTS)","volume":"52","author":"Capodanno","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023053100335289000_jeac274-B25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 Esc\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"2023053100335289000_jeac274-B26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacc.2021.10.044","article-title":"Association of lipoprotein(a) with atherosclerotic plaque progression","volume":"79","author":"Kaiser","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B27","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1093\/eurjpc\/zwaa063","article-title":"Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction, and estimating benefits from novel interventions","volume":"28","author":"Welsh","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"2023053100335289000_jeac274-B28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijcard.2006.03.047","article-title":"Degeneration of native and tissue prosthetic valve in aortic position: do statins play an effective role in prevention?","volume":"116","author":"Colli","year":"2007","journal-title":"Int J Cardiol"},{"key":"2023053100335289000_jeac274-B29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12350-020-02411-x","article-title":"Detecting native and bioprosthetic aortic valve disease using 18F-sodium fluoride: clinical implications","volume":"28","author":"Fletcher","year":"2021","journal-title":"J Nucl Cardiol"},{"key":"2023053100335289000_jeac274-B30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2967\/jnumed.121.262304","article-title":"Latest advances in multimodality imaging of aortic stenosis","volume":"63","author":"Tzolos","year":"2022","journal-title":"J Nucl Med"},{"key":"2023053100335289000_jeac274-B31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","article-title":"Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population","volume":"63","author":"Kamstrup","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B32","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCGENETICS.113.000400","article-title":"Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective Mendelian randomization study and replication in a case-control cohort","volume":"7","author":"Arsenault","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"2023053100335289000_jeac274-B33","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jacc.2012.11.033","article-title":"Apob\/ApoA-I ratio is associated with increased risk of bioprosthetic valve degeneration","volume":"61","author":"Mahjoub","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B34","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1136\/heartjnl-2016-309541","article-title":"Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration","volume":"102","author":"Nsaibia","year":"2016","journal-title":"Heart"},{"key":"2023053100335289000_jeac274-B35","author":"Singhal"},{"key":"2023053100335289000_jeac274-B36","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1089\/ten.tea.2011.0046","article-title":"Immune response in patients receiving a bioprosthetic heart valve: lack of response with decellularized valves","volume":"17","author":"Bloch","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"2023053100335289000_jeac274-B37","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1089\/ten.tea.2016.0474","article-title":"Alpha-Gal inactivated heart valve bioprostheses exhibit an anti-calcification propensity similar to knockout tissues","volume":"23","author":"Naso","year":"2017","journal-title":"Tissue Eng Part A"},{"key":"2023053100335289000_jeac274-B38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41591-022-01682-w","article-title":"The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration","volume":"28","author":"Senage","year":"2022","journal-title":"Nat Med"},{"key":"2023053100335289000_jeac274-B39","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/j.jacc.2016.09.958","article-title":"Prosthetic heart valve thrombosis","volume":"68","author":"Dangas","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2023053100335289000_jeac274-B40","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jcmg.2021.11.015","article-title":"18F-GP1 Positron emission tomography and bioprosthetic aortic valve thrombus","volume":"15","author":"Bing","year":"2022","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/24\/6\/759\/50464903\/jeac274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/24\/6\/759\/50464903\/jeac274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T04:59:09Z","timestamp":1685509149000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/24\/6\/759\/6994364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,1,20]]},"published-print":{"date-parts":[[2023,5,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jeac274","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,1,20]]}}}