{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:10:28Z","timestamp":1787973028098,"version":"build-2784847793"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Paravalvular regurgitation (PVR) is a common complication after transcatheter aortic valve replacement (TAVR) that poses an increased risk of rehospitalization for heart failure and mortality. The aim of this study was to assess the accuracy of haemodynamic indices to predict relevant PVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this prospective single-centre clinical trial, four haemodynamic indices of PVR measured during TAVR were assessed for their correlation with gold standard cardiac magnetic resonance (CMR)-derived regurgitant fraction (CMR-RF) at 1 month follow-up: diastolic delta (DD), heart rate-adjusted diastolic delta (HR-DD), aortic regurgitation index (ARI), and aortic regurgitation index ratio (ARI ratio). These haemodynamic indices were analysed for their ability to predict relevant PVR (defined as CMR-RF &amp;gt; 20%) using receiver operating characteristic (ROC) curves with corresponding area under the ROC curves (AUCs). A total of 77 patients were included and had CMR performed 41 \u00b1 14 days after TAVR. Mean CMR-RF was 12.4 \u00b1 9.3%. Fifteen (19.5%) patients had CMR-RF &amp;gt; 20%. DD had the best correlation with CMR-RF and the highest AUC to predict relevant PVR (0.82; 95% CI, 0.72\u20130.92), followed by HR-DD (AUC 0.78; 95% CI, 0.67\u20130.89), ARI (AUC 0.78; 95% CI, 0.66\u20130.89), and ARI ratio (AUC 0.65; 95% CI, 0.49\u20130.81). The optimal cut-off value for DD was 32 mmHg, with sensitivity of 69% and specificity of 77% in predicting relevant PVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DD measured during TAVR best predicts relevant PVR. Correction for heart rate (HR-DD) or systolic blood pressure (ARI, ARI ratio) did not improve this predictive value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jead033","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T21:44:11Z","timestamp":1675979051000},"page":"1072-1081","source":"Crossref","is-referenced-by-count":11,"title":["Diastolic delta best predicts paravalvular regurgitation after transcatheter aortic valve replacement as assessed by cardiac magnetic resonance: the APPOSE trial"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-7667","authenticated-orcid":false,"given":"Maxim J P","family":"Rooijakkers","sequence":"first","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels A","family":"Stens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"},{"name":"Department of Physiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen H","family":"van Wely","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"van der Wulp","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rodwell","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section Biostatistics, Radboud Institute for Health Sciences , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Gehlmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen A F M","family":"van Garsse","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0407-2901","authenticated-orcid":false,"given":"Guillaume S C","family":"Geuzebroek","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel W A","family":"Verkroost","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Habets","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloua","family":"El Messaoudi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick H J","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"},{"name":"Research Institute for Sports and Exercise Sciences, Liverpool John Moores University , Liverpool L3 5UX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Nijveldt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"van Royen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Geert Grooteplein Zuid 10, 6525 GA Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"2023072413342577500_jead033-B1","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N Engl J Med"},{"key":"2023072413342577500_jead033-B2","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N Engl J Med"},{"key":"2023072413342577500_jead033-B3","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jacc.2021.11.062","article-title":"2-Year outcomes after transcatheter versus surgical aortic valve replacement in low-risk patients","volume":"79","author":"Forrest","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2023072413342577500_jead033-B4","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1161\/CIRCULATIONAHA.120.051547","article-title":"Comparison of self-expanding bioprostheses for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: SCOPE 2 randomized clinical trial","volume":"142","author":"Tamburino","year":"2020","journal-title":"Circulation"},{"key":"2023072413342577500_jead033-B5","doi-asserted-by":"crossref","first-page":"971762","DOI":"10.3389\/fcvm.2022.971762","article-title":"A 20-year journey in transcatheter aortic valve implantation: evolution to current eminence","volume":"9","author":"Kalogeropoulos","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2023072413342577500_jead033-B6","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jacc.2013.01.047","article-title":"Incidence, predictors, and outcomes of aortic regurgitation after transcatheter aortic valve replacement: meta-analysis and systematic review of literature","volume":"61","author":"Athappan","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2023072413342577500_jead033-B7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.4244\/EIJ-D-20-01293","article-title":"Paravalvular regurgitation after transcatheter aortic valve replacement in intermediate-risk patients: a pooled PARTNER 2 study","volume":"17","author":"Chau","year":"2022","journal-title":"EuroIntervention"},{"key":"2023072413342577500_jead033-B8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4244\/EIJ-D-21-00784","article-title":"Five-year outcomes of mild paravalvular regurgitation after transcatheter aortic valve implantation","volume":"18","author":"Okuno","year":"2022","journal-title":"EuroIntervention"},{"key":"2023072413342577500_jead033-B9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12968-015-0134-0","article-title":"Quantitative assessment of paravalvular regurgitation following transcatheter aortic valve replacement","volume":"17","author":"Crouch","year":"2015","journal-title":"J Cardiovasc Magn Reson"},{"key":"2023072413342577500_jead033-B10","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1136\/heartjnl-2014-305665","article-title":"Aortic regurgitation severity after transcatheter aortic valve implantation is underestimated by echocardiography compared with MRI","volume":"100","author":"Orwat","year":"2014","journal-title":"Heart"},{"key":"2023072413342577500_jead033-B11","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.4244\/EIJY15M03_06","article-title":"Evaluation of aortic regurgitation after transcatheter aortic valve implantation: aortic root angiography in comparison to cardiac magnetic resonance","volume":"11","author":"Frick","year":"2016","journal-title":"EuroIntervention"},{"key":"2023072413342577500_jead033-B12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/CIRCULATIONAHA.113.002310","article-title":"Accurate assessment of aortic stenosis: a review of diagnostic modalities and hemodynamics","volume":"129","author":"Saikrishnan","year":"2014","journal-title":"Circulation"},{"key":"2023072413342577500_jead033-B13","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.4244\/EIJV8I12A213","article-title":"Incidence, outcome and correlates of residual paravalvular aortic regurgitation after transcatheter aortic valve implantation and importance of haemodynamic assessment","volume":"8","author":"Patsalis","year":"2013","journal-title":"EuroIntervention"},{"key":"2023072413342577500_jead033-B14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4244\/EIJY14M12_08","article-title":"Heart-rate adjustment of transcatheter haemodynamics improves the prognostic evaluation of paravalvular regurgitation after transcatheter aortic valve implantation","volume":"11","author":"Jilaihawi","year":"2015","journal-title":"EuroIntervention"},{"key":"2023072413342577500_jead033-B15","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jacc.2011.11.048","article-title":"Aortic regurgitation index defines severity of peri-prosthetic regurgitation and predicts outcome in patients after transcatheter aortic valve implantation","volume":"59","author":"Sinning","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2023072413342577500_jead033-B16","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jcin.2015.12.271","article-title":"Pre-procedural hemodynamic status improves the discriminatory value of the aortic regurgitation index in patients undergoing transcatheter aortic valve replacement","volume":"9","author":"Sinning","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B17","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/eurheartj\/ehaa799","article-title":"Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research","volume":"42","author":"G\u00e9n\u00e9reux","year":"2021","journal-title":"Eur Heart J"},{"key":"2023072413342577500_jead033-B18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12968-014-0093-x","article-title":"The role of cardiovascular magnetic resonance in stratifying paravalvular leak severity after transcatheter aortic valve replacement: an observational outcome study","volume":"16","author":"Hartlage","year":"2014","journal-title":"J Cardiovasc Magn Reson"},{"key":"2023072413342577500_jead033-B19","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jcin.2012.04.011","article-title":"Impact of paravalvular leakage on outcome in patients after transcatheter aortic valve implantation","volume":"5","author":"Vasa-Nicotera","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B20","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.amjcard.2014.02.038","article-title":"Comparison of two- and three-dimensional transthoracic echocardiography to cardiac magnetic resonance imaging for assessment of paravalvular regurgitation after transcatheter aortic valve implantation","volume":"113","author":"Altiok","year":"2014","journal-title":"Am J Cardiol"},{"key":"2023072413342577500_jead033-B21","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"2023072413342577500_jead033-B22","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.jacc.2018.09.014","article-title":"Transcatheter aortic valve replacement with a repositionable self-expanding prosthesis: the PORTICO-I trial 1-year outcomes","volume":"72","author":"S\u00f8ndergaard","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2023072413342577500_jead033-B23","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jcin.2017.05.021","article-title":"Implantation and 30-day follow-up on all 4 valve sizes within the portico transcatheter aortic bioprosthetic family","volume":"10","author":"Mollmann","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jacc.2016.05.059","article-title":"Cardiovascular magnetic resonance to evaluate aortic regurgitation after transcatheter aortic valve replacement","volume":"68","author":"Ribeiro","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2023072413342577500_jead033-B25","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1093\/ehjci\/jeab253","article-title":"Multi-modality imaging assessment of native valvular regurgitation: an EACVI and ESC council of valvular heart disease position paper","volume":"23","author":"Lancellotti","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2023072413342577500_jead033-B26","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N Engl J Med"},{"key":"2023072413342577500_jead033-B27","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1910555","article-title":"Five-year outcomes of transcatheter or surgical aortic-valve replacement","volume":"382","author":"Makkar","year":"2020","journal-title":"N Engl J Med"},{"key":"2023072413342577500_jead033-B28","doi-asserted-by":"crossref","first-page":"e011848","DOI":"10.1161\/CIRCINTERVENTIONS.122.011848","article-title":"Reduction of gastrointestinal bleeding in patients with Heyde syndrome undergoing transcatheter aortic valve implantation","volume":"15","author":"Goltstein","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/joic.12378","article-title":"Post-dilation in transcatheter aortic valve replacement: a systematic review and meta-analysis","volume":"30","author":"Wang","year":"2017","journal-title":"J Interv Cardiol"},{"key":"2023072413342577500_jead033-B30","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.4244\/EIJY15M11_04","article-title":"Balloon post-dilation and valve-in-valve implantation for the reduction of paravalvular leakage with use of the self-expanding CoreValve prosthesis","volume":"11","author":"Stundl","year":"2016","journal-title":"EuroIntervention"},{"key":"2023072413342577500_jead033-B31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"202","journal-title":"Eur Heart J"},{"key":"2023072413342577500_jead033-B32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41569-018-0147-0","article-title":"Percutaneous management of paravalvular leaks","volume":"16","author":"Giblett","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2023072413342577500_jead033-B33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jcmg.2015.01.003","article-title":"Optimal imaging for guiding TAVR: transesophageal or transthoracic echocardiography, or just fluoroscopy?","volume":"8","author":"Kronzon","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"2023072413342577500_jead033-B34","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1093\/eurheartj\/ehw115","article-title":"Adjudicating paravalvular leaks of transcatheter aortic valves: a critical appraisal","volume":"37","author":"Abdelghani","year":"2016","journal-title":"Eur Heart J"},{"key":"2023072413342577500_jead033-B35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0002-9149(64)90027-X","article-title":"Left retrograde cardioangiography in acquired cardiac disease: technic, indications and interpretations in 700 cases","volume":"14","author":"Sellers","year":"1964","journal-title":"Am J Cardiol"},{"key":"2023072413342577500_jead033-B36","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1053\/j.semtcvs.2020.11.025","article-title":"Aortic regurgitation index ratio is a strong predictor of 1-year mortality after transcatheter aortic valve implantation using self-expanding devices","volume":"33","author":"van Wely","year":"2021","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"2023072413342577500_jead033-B37","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/ccd.26298","article-title":"Aortic regurgitation following transcatheter aortic valve replacement: impact of preprocedural left ventricular diastolic filling patterns on late clinical outcomes","volume":"87","author":"Halkin","year":"2016","journal-title":"Catheter Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B38","doi-asserted-by":"crossref","first-page":"E174","DOI":"10.1002\/ccd.25848","article-title":"Novel hemodynamic index for assessment of aortic regurgitation after transcatheter aortic valve replacement","volume":"86","author":"Bugan","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B39","doi-asserted-by":"crossref","first-page":"e012430","DOI":"10.1161\/JAHA.119.012430","article-title":"Time-integrated aortic regurgitation index helps guide balloon postdilation during transcatheter aortic valve replacement and predicts survival","volume":"8","author":"Kumar","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2023072413342577500_jead033-B40","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jcin.2016.02.012","article-title":"Hemodynamic assessment of aortic regurgitation after transcatheter aortic valve replacement: the diastolic pressure-time index","volume":"9","author":"H\u00f6llriegel","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B41","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jcin.2020.11.014","article-title":"Online quantitative aortographic assessment of aortic regurgitation after TAVR: results of the OVAL study","volume":"14","author":"Modolo","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"2023072413342577500_jead033-B42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jcin.2017.08.045","article-title":"A novel angiographic quantification of aortic regurgitation after TAVR provides an accurate estimation of regurgitation fraction derived from cardiac magnetic resonance imaging","volume":"11","author":"Abdel-Wahab","year":"2018","journal-title":"JACC Cardiovasc Interv"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/24\/8\/1072\/50946196\/jead033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/24\/8\/1072\/50946196\/jead033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T09:35:27Z","timestamp":1690191327000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/24\/8\/1072\/7076929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,3,14]]},"published-print":{"date-parts":[[2023,7,24]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jead033","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,3,14]]}}}