{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:32:16Z","timestamp":1740166336230,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The pressure increase per time unit (dP\/dt) in aortic stenosis (AS) jet velocity is assumed to have inter-individual variability in the progressive AS stage. We sought to examine the association of aortic valve (AoV) Doppler-derived dP\/dt in patients with mild to moderate AS with risk of progression to severe disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 481 patients diagnosed with mild or moderate AS [peak aortic jet velocity (Vmax) between 2 and 4 m\/s] according to echocardiographic criteria were included. AoV Doppler-derived dP\/dt was determined by measuring the time needed for the pressure to increase at a velocity of the AoV jet from 1 m\/s to 2 m\/s. During a median follow-up period of 2.7 years, 12 of 404 (3%) patients progressed from mild to severe AS and 31 of 77 (40%) patients progressed from moderate to severe AS. AoV Doppler-derived dP\/dt had a good ability to predict risk of progression to severe AS (area under the curve = 0.868) and the cut-off value was 600 mmHg\/s. In multivariable logistic regression, initial AoV calcium score (adjusted odds ratio [aOR], 1.79; 95% confidence interval [CI], 1.18\u20132.73; P = 0.006) and AoV Doppler-derived dP\/dt (aOR, 1.52\/100 mmHg\/s higher dP\/dt; 95% CI, 1.10\u20132.05; P = 0.012) were associated with progression to severe AS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>AoV Doppler-derived dP\/dt above 600 mmHg\/s was associated with risk of AS progression to the severe stage in patients with mild to moderate AS. This may be useful in individualized surveillance strategies for AS progression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead099","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T02:47:52Z","timestamp":1683773272000},"page":"1146-1153","source":"Crossref","is-referenced-by-count":4,"title":["How can progression be predicted in patients with mild to moderate aortic valve stenosis?"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-1714","authenticated-orcid":false,"given":"Jeong Hun","family":"Seo","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine , Chuncheon-si, Gangwon-do, 24289, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine , Chuncheon-si, Gangwon-do, 24289, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Jin","family":"Chun","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine , Chuncheon-si, Gangwon-do, 24289, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong-Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine , Chuncheon-si, Gangwon-do, 24289, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Ryul","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine , Chuncheon-si, Gangwon-do, 24289, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-8738","authenticated-orcid":false,"given":"Dong Ryeol","family":"Ryu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine , Chuncheon-si, Gangwon-do, 24289, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"2023082310040321600_jead099-B1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.748137","article-title":"Trends in mortality from aortic stenosis in Europe: 2000\u20132017","volume":"8","author":"Hartley","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2023082310040321600_jead099-B2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2023082310040321600_jead099-B3","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.110.006767","article-title":"Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the national heart and lung and blood institute aortic stenosis working group. Executive summary: calcific aortic valve disease-2011 update","volume":"124","author":"Rajamannan","year":"2011","journal-title":"Circulation"},{"key":"2023082310040321600_jead099-B4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/ehjci\/jew335","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"18","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2023082310040321600_jead099-B5","doi-asserted-by":"crossref","first-page":"G19","DOI":"10.1530\/ERP-20-0035","article-title":"Echocardiographic assessment of aortic stenosis: a practical guideline from the British Society of Echocardiography","volume":"8","author":"Ring","year":"2021","journal-title":"Echo Res Pract"},{"key":"2023082310040321600_jead099-B6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00392-019-01539-2","article-title":"Expert consensus document on the assessment of the severity of aortic valve stenosis by echocardiography to provide diagnostic conclusiveness by standardized verifiable documentation","volume":"109","author":"Hagendorff","year":"2020","journal-title":"Clin Res Cardiol"},{"key":"2023082310040321600_jead099-B7","first-page":"e72","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"2023082310040321600_jead099-B8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s10554-020-02048-4","article-title":"Validity of visual assessment of aortic valve morphology in patients with aortic stenosis using two-dimensional echocardiography","volume":"37","author":"Nemchyna","year":"2021","journal-title":"Int J Cardiovasc Imaging"},{"key":"2023082310040321600_jead099-B9","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/01.CIR.101.21.2497","article-title":"New insights into the progression of aortic stenosis","volume":"101","author":"Palta","year":"2000","journal-title":"Circulation"},{"key":"2023082310040321600_jead099-B10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005133","article-title":"Traditional cardiovascular risk factors and their relation to future surgery for valvular heart disease or ascending aortic disease: a case-referent study","volume":"6","author":"Ljungberg","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2023082310040321600_jead099-B11","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jacc.2017.01.025","article-title":"Association between cardiovascular risk factors and aortic stenosis: the CANHEART aortic stenosis study","volume":"69","author":"Yan","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2023082310040321600_jead099-B12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4330\/wjc.v8.i2.192","article-title":"Diagnosis and management of patients with asymptomatic severe aortic stenosis","volume":"8","author":"Katayama","year":"2016","journal-title":"World J Cardiol"},{"key":"2023082310040321600_jead099-B13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/ehjci\/jeaa075","article-title":"Progression of aortic stenosis and echocardiographic criteria for its severity","volume":"21","author":"Kebed","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2023082310040321600_jead099-B14","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.jacc.2006.03.002","article-title":"Valvular aortic stenosis: disease severity and timing of intervention","volume":"47","author":"Otto","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2023082310040321600_jead099-B15","article-title":"Initial changes in peak aortic jet velocity and mean gradient predict progression to severe aortic stenosis","volume":"30","author":"Nayeri","year":"2020","journal-title":"Int J Cardiol Heart Vasc"},{"key":"2023082310040321600_jead099-B16","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1161\/01.CIR.101.16.1947","article-title":"Rate of change in aortic valve area during a cardiac cycle can predict the rate of hemodynamic progression of aortic stenosis","volume":"101","author":"Lester","year":"2000","journal-title":"Circulation"}],"container-title":["European Heart Journal - 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