{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T15:21:36Z","timestamp":1785597696562,"version":"3.56.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC2505600"],"award-info":[{"award-number":["2022YFC2505600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2020YFC2004800"],"award-info":[{"award-number":["2020YFC2004800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["Z201100006820087"],"award-info":[{"award-number":["Z201100006820087"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Interdisciplinary Cooperation Project of Beijing Nova Program","award":["Z211100002121165"],"award-info":[{"award-number":["Z211100002121165"]}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing, China","doi-asserted-by":"publisher","award":["7222046"],"award-info":[{"award-number":["7222046"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study sought to evaluate the association of coronary angiography-derived index of microcirculatory resistance (angio-IMR) measured after primary percutaneous coronary intervention (PPCI) with the evolution of infarct pathology during 3-month follow-up after ST-segment-elevation myocardial infarction (STEMI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>Patients with STEMI undergoing PPCI were prospectively enrolled between October 2019 and August 2021. Angio-IMR was calculated using computational flow and pressure simulation immediately after PPCI. Cardiac magnetic resonance (CMR) imaging was performed at a median of 3.6 days and 3 months. A total of 286 STEMI patients (mean age 57.8 years, 84.3% men) with both angio-IMR and CMR at baseline were included. High angio-IMR (&amp;gt;40 U) occurred in 84 patients (29.4%) patients. Patients with angio-IMR &amp;gt;40 U had a higher prevalence and extent of MVO. An angio-IMR &amp;gt;40 U was a multivariable predictor of infarct size with a three-fold higher risk of final infarct size &amp;gt;25% (adjusted OR 3.00, 95% CI 1.23\u20137.32, P = 0.016). Post-procedure angio-IMR &amp;gt;40 U significantly predicted presence (adjusted OR 5.52, 95% CI 1.65\u201318.51, P = 0.006) and extent (beta coefficient 0.27, 95% CI 0.01\u20130.53, P = 0.041) of myocardial iron at follow-up. Compared with patients with angio-IMR \u226440 U, those with angio-IMR &amp;gt;40 U had less regression of infarct size and less resolution of myocardial iron at follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Angio-IMR immediately post-PPCI showed a significant association with the extent and evolution of infarct pathology. An angio-IMR &amp;gt;40 U indicated extensive microvascular damage with less regression of infarct size and more persistent iron at follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead141","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T03:31:26Z","timestamp":1686799886000},"page":"1640-1652","source":"Crossref","is-referenced-by-count":29,"title":["Coronary angiography-derived index of microcirculatory resistance and evolution of infarct pathology after ST-segment-elevation myocardial infarction"],"prefix":"10.1093","volume":"24","author":[{"given":"Xiao","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gong","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ai","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Que","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Huo","sequence":"additional","affiliation":[{"name":"Institute of 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