{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:57:55Z","timestamp":1792151875522,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010578","name":"German Cardiac Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010578","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Berlin Center for Translational Vascular Biomedicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Coronary microevaginations (CMEs) represent an outward bulge of coronary plaques and have been introduced as a sign of adverse vascular remodelling following coronary device implantation. However, their role in atherosclerosis and plaque destabilization in the absence of coronary intervention is unknown. This study aimed to investigate CME as a novel feature of plaque vulnerability and to characterize its associated inflammatory cell\u2013vessel\u2013wall interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 557 patients from the translational OPTICO-ACS study programme underwent optical coherence tomography imaging of the culprit vessel and simultaneous immunophenotyping of the culprit lesion (CL). Two hundred and fifty-eight CLs had a ruptured fibrous cap (RFC) and one hundred had intact fibrous cap (IFC) acute coronary syndrome (ACS) as an underlying pathophysiology. CMEs were significantly more frequent in CL when compared with non-CL (25 vs. 4%, P &amp;lt; 0.001) and were more frequently observed in lesions with IFC-ACS when compared with RFC-ACS (55.0 vs. 12.7%, P &amp;lt; 0.001). CMEs were particularly prevalent in IFC-ACS-causing CLs independent of a coronary bifurcation (IFC-ICB) when compared with IFC-ACS with an association to a coronary bifurcation (IFC-ACB, 65.4 vs. 43.7%, P = 0.030). CME emerged as the strongest independent predictor of IFC-ICB (relative risk 3.36, 95% confidence interval 1.67\u20136.76, P = 0.001) by multivariable regression analysis. IFC-ICB demonstrated an enrichment of monocytes in both culprit blood analysis (culprit ratio: 1.1 \u00b1 0.2 vs. 0.9 \u00b1 0.2, P = 0.048) and aspirated culprit thrombi (326 \u00b1 162 vs. 96 \u00b1 87 cells\/mm2, P = 0.017), while IFC-ACB confirmed the accumulation of CD4+ T cells, as recently described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides novel evidence for a pathophysiological involvement of CME in the development of IFC-ACS and provides first evidence for a distinct pathophysiological pathway for IFC-ICB, driven by CME-derived flow disturbances and inflammatory activation involving the innate immune system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Registration of the study at clinicalTrials.gov (NCT03129503).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jead154","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T12:55:13Z","timestamp":1688388913000},"page":"175-184","source":"Crossref","is-referenced-by-count":8,"title":["Coronary microevaginations characterize culprit plaques and their inflammatory microenvironment in a subtype of acute coronary syndrome with intact fibrous cap: results from the prospective translational OPTICO-ACS study"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-6809","authenticated-orcid":false,"given":"Claudio","family":"Seppelt","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), Berlin 12203 , Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef S","family":"Abdelwahed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), Berlin 12203 , Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denitsa","family":"Meteva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), Berlin 12203 , Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-2292","authenticated-orcid":false,"given":"Gregor","family":"Nelles","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), Berlin 12203 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E","family":"St\u00e4hli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), Berlin 12203 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-4929","authenticated-orcid":false,"given":"Aslihan","family":"Erbay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), Berlin 12203 , Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-1770","authenticated-orcid":false,"given":"Nicolle","family":"Kr\u00e4nkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), Berlin 12203 , Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0663-6769","authenticated-orcid":false,"given":"Lara","family":"Sieronski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Berlin and Charit\u00e9 University Medicine Berlin , Campus Benjamin-Franklin (CBF), 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