{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:02:22Z","timestamp":1787504542652,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alnylam"},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020150","name":"Bioventrix","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GE Healthcare, Medtronic, and Novartis"},{"name":"Netherlands Heart Foundation"},{"name":"Netherlands Heart Institute and the European Community Framework KP7 Programme"},{"DOI":"10.13039\/100014384","name":"Amarin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014384","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Athera"},{"DOI":"10.13039\/501100022274","name":"Daiichi Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi Aventis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Left ventricular myocardial work (LVMW) is a novel echocardiographic-based method to assess left ventricular (LV) function using pressure\u2013strain loops taking into account LV afterload. The aim of this study was to evaluate the prognostic value of LVMW indices in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>LV global work index (LV GWI), LV global constructive work (LV GCW), LV global wasted work (LV GWW), and LV global work efficiency (LV GWE) were calculated in 281 patients with severe AS [age 82, interquartile range (IQR) 78\u201385 years, 52% male] before the TAVR procedure. LV systolic pressure was derived non-invasively by adding the mean aortic gradient to the brachial systolic pressure to adjust for afterload and calculate LVMW indices. Overall, the average LV GWI was 1872 \u00b1 753 mmHg%, GCW 2240 \u00b1 797 mmHg%, GWW 200 (IQR 127\u2013306) mmHg%, and GWE 89 (IQR 84\u201393)%. During a median follow-up of 52 (IQR 41\u201367) months, 64 patients died. While LV GWI was independently associated with all-cause mortality (Hazard ratio per-tertile-increase 0.639; 95%CI 0.463\u20130.883; P = 0.007), LV GCW, GWW, and GWE were not. When added to a basal model, LV GWI yielded a higher increase in predictivity compared to the left ventricular ejection fraction as well as LV global longitudinal strain and LV GCW, and also across the different haemodynamic categories (including low-flow low-gradient) of AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LV GWI is independently associated with all-cause mortality in patients undergoing TAVR and has a higher prognostic value compared to both conventional and advanced parameters of LV systolic function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jead157","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T17:48:02Z","timestamp":1688579282000},"page":"1682-1689","source":"Crossref","is-referenced-by-count":25,"title":["Prognostic value of left ventricular myocardial work indices in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-8258","authenticated-orcid":false,"given":"Hoi W","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-9439","authenticated-orcid":false,"given":"Federico","family":"Fortuni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"},{"name":"Department of Cardiology, San Giovanni Battista Hospital , Foligno , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steele C","family":"Butcher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4521-8698","authenticated-orcid":false,"given":"Frank","family":"van der Kley","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4190-3156","authenticated-orcid":false,"given":"Arend","family":"de Weger","sequence":"additional","affiliation":[{"name":"Department of Cardio-thoracic Surgery, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"},{"name":"Netherlands Heart Institute , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-0500","authenticated-orcid":false,"given":"Jeroen J","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-5769","authenticated-orcid":false,"given":"Nina","family":"Ajmone Marsan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"2023112322325045600_jead157-B1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary presentation and management of valvular heart disease: the EURObservational Research Programme Valvular Heart Disease II Survey","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation"},{"key":"2023112322325045600_jead157-B2","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/CIRCULATIONAHA.119.043391","article-title":"Global, regional, and national burden of calcific aortic valve and degenerative mitral valve diseases, 1990\u20132017","volume":"141","author":"Yadgir","year":"2020","journal-title":"Circulation"},{"key":"2023112322325045600_jead157-B3","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cjca.2014.04.026","article-title":"Left ventricular remodelling in aortic stenosis","volume":"30","author":"Rassi","year":"2014","journal-title":"Can J Cardiol"},{"issue":"5 Suppl 1","key":"2023112322325045600_jead157-B4","first-page":"e1","article-title":"[2021 ESC\/EACTS guidelines for the management of valvular heart disease]","volume":"23","author":"Vahanian","year":"2022","journal-title":"G Ital Cardiol (Rome)"},{"key":"2023112322325045600_jead157-B5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2021.05.047","article-title":"Markers of myocardial damage predict mortality in patients with aortic stenosis","volume":"78","author":"Kwak","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2023112322325045600_jead157-B6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/CIRCULATIONAHA.120.050763","article-title":"Changing the paradigm in the management of valvular heart disease: in addition to left ventricular ejection fraction, focus on the myocardium","volume":"143","author":"Fortuni","year":"2021","journal-title":"Circulation"},{"key":"2023112322325045600_jead157-B7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcmg.2018.11.005","article-title":"Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis: an individual participant data meta-analysis","volume":"12","author":"Magne","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2023112322325045600_jead157-B8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.echo.2020.10.014","article-title":"Left ventricular myocardial work in patients with severe aortic stenosis","volume":"34","author":"Fortuni","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"key":"2023112322325045600_jead157-B9","doi-asserted-by":"crossref","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2023112322325045600_jead157-B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2008.11.029","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"22","author":"Baumgartner","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"2023112322325045600_jead157-B11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"2023112322325045600_jead157-B12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","article-title":"Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"2023112322325045600_jead157-B13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/eurheartj\/ehs016","article-title":"A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work","volume":"33","author":"Russell","year":"2012","journal-title":"Eur Heart J"},{"key":"2023112322325045600_jead157-B14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/ehjci\/jeaa257","article-title":"Myocardial work assessment in severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"22","author":"Jain","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2023112322325045600_jead157-B15","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3390\/jcm11030747","article-title":"Non-invasive myocardial work in patients with severe aortic stenosis","volume":"11","author":"De Rosa","year":"2022","journal-title":"J Clin Med"},{"key":"2023112322325045600_jead157-B16","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3390\/jcm11061555","article-title":"Prognostic value of non-invasive global myocardial work in asymptomatic aortic stenosis","volume":"11","author":"Ilardi","year":"2022","journal-title":"J Clin Med"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/advance-article-pdf\/doi\/10.1093\/ehjci\/jead157\/50902556\/jead157.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/24\/12\/1682\/53711183\/jead157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/24\/12\/1682\/53711183\/jead157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:49:09Z","timestamp":1700761749000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/24\/12\/1682\/7220095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,6]]},"references-count":16,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,7,6]]},"published-print":{"date-parts":[[2023,11,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jead157","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,7,6]]}}}