{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:23Z","timestamp":1792785863705,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Improvement and Research","award":["CFH 2022-4-4037"],"award-info":[{"award-number":["CFH 2022-4-4037"]}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec-Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Research Chair in Valvular Heart Diseases"},{"DOI":"10.13039\/501100000028","name":"Circulatory and Respiratory Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000028","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Research Chair on Women\u2019s Cardiac Valvular Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Remnant cholesterol (RC) seems associated with native aortic stenosis. Bioprosthetic valve degeneration may share similar lipid-mediated pathways with aortic stenosis. We aimed to investigate the association of RC with the progression of bioprosthetic aortic valve degeneration and ensuing clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We enrolled 203 patients with a median of 7.0 years (interquartile range: 5.1\u20139.2) after surgical aortic valve replacement. RC concentration was dichotomized by the top RC tertile (23.7 mg\/dL). At 3-year follow-up, 121 patients underwent follow-up visit for the assessment of annualized change in aortic valve calcium density (AVCd). RC levels showed a curvilinear relationship with an annualized progression rate of AVCd, with increased progression rates when RC &amp;gt;23.7 mg\/dL (P = 0.008). There were 99 deaths and 46 aortic valve re-interventions in 133 patients during a median clinical follow-up of 8.8 (8.7\u20139.6) years. RC &amp;gt;23.7 mg\/dL was independently associated with mortality or re-intervention (hazard ratio: 1.98; 95% confidence interval: 1.31\u20132.99; P = 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated RC is independently associated with faster progression of bioprosthetic valve degeneration and increased risk of all-cause mortality or aortic valve re-intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jead159","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:50:34Z","timestamp":1688565034000},"page":"1690-1699","source":"Crossref","is-referenced-by-count":3,"title":["Association between remnant cholesterol and progression of bioprosthetic valve degeneration"],"prefix":"10.1093","volume":"24","author":[{"given":"Ziang","family":"Li","sequence":"first","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"},{"name":"State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College , Beijing 100037 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"},{"name":"State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College , Beijing 100037 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Salaun","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-2004","authenticated-orcid":false,"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaziz","family":"Dahou","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Zenses","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute for Medical Information Processing, Biometry, and Epidemiology, Pettenkofer School of Public Health LMU Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":false,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College , Beijing 100037 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-740X","authenticated-orcid":false,"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[{"name":"Research Center, Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (Quebec Heart & Lung Institute), Universit\u00e9 Laval, 2725 Chemin Sainte-Foy , Qu\u00e9bec city, Qu\u00e9bec G1V-4G5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"2023112322350298400_jead159-B1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2015.01.052","article-title":"National trends in utilization and in-hospital outcomes of mechanical versus bioprosthetic aortic valve replacements","volume":"149","author":"Isaacs","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023112322350298400_jead159-B2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jtcvs.2008.08.015","article-title":"Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database","volume":"137","author":"Brown","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023112322350298400_jead159-B3","article-title":"Prognosis after surgical replacement with a 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