{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:48:01Z","timestamp":1770328081264,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To assess the additional prognostic significance of echocardiographic parameters of subpulmonary left ventricular (LV) size and function in patients with a systemic right ventricle (SRV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>All adults with an SRV who underwent transthoracic echocardiography in 2010\u201318 at a large tertiary centre were identified. Biventricular size and function were assessed at the most recent examination. The study endpoint was all-cause mortality or heart\/heart\u2013lung transplantation. We included 180 patients, with 100 (55.6%) males, with a mean age of 42.4 \u00b1 12.3 years, of whom 103 (57.2%) had undergone Mustard\/Senning operations and 77 (42.8%) had congenitally corrected transposition of great arteries. Over 4.9 (3.8\u20135.7) years, 28 (15.6%) patients died and 4 (2.2%) underwent heart or heart\u2013lung transplantation. Univariable predictors of the study endpoint included age, New York Heart Association functional Class III or IV, history of atrial arrhythmias, presence of a pacemaker or cardioverter defibrillator, high B-type natriuretic peptide, and echocardiographic markers of SRV and subpulmonary LV size and function. On multivariable Cox analysis of echocardiographic variables, indexed LV end-systolic diameter [ESDi; hazard ratio (HR) 2.77 (95% confidence interval, CI) 1.35\u20135.68, P = 0.01], LV fractional area change [FAC; HR 0.7 (95% CI 0.57\u20130.85), P = 0.002), SRV basal diameter [HR 1.66 (95% CI 1.21\u20132.29), P = 0.005], and SRV FAC [HR 0.65 (95% CI 0.49\u20130.87), P = 0.008] remained predictive of mortality or transplantation. On receiver-operating characteristic analysis, subpulmonary LV parameters performed better than SRV markers in predicting adverse events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SRV basal diameter, SRV FAC, LV ESDi, and LV FAC are significantly and independently associated with mortality and transplantation in adults with an SRV. Accurate echocardiographic assessment of both SRV and subpulmonary LV is, therefore, essential to inform risk stratification and management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead173","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T18:56:59Z","timestamp":1689447419000},"page":"58-65","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic significance of subpulmonary left ventricular size and function in patients with a systemic right ventricle"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-8551","authenticated-orcid":false,"given":"Elena","family":"Surkova","sequence":"first","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"},{"name":"National Heart and Lung Institute, Imperial College London , Guy Scadding Building, Dovehouse St, London SW3 6LY , UK"},{"name":"Harefield Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Hill End Rd, Harefield, Uxbridge UB9 6JH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Constantine","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"},{"name":"National Heart and Lung Institute, Imperial College London , Guy Scadding Building, Dovehouse St, London SW3 6LY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-5574","authenticated-orcid":false,"given":"Teresa","family":"Segura de la Cal","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"},{"name":"Adult Congenital Heart Disease Unit, University Hospital 12 de Octubre , Av. de C\u00f3rdoba, s\/n, 28041 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Bispo","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"West","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxy","family":"Senior","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"},{"name":"National Heart and Lung Institute, Imperial College London , Guy Scadding Building, Dovehouse St, London SW3 6LY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"},{"name":"National Heart and Lung Institute, Imperial College London , Guy Scadding Building, Dovehouse St, London SW3 6LY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-5559","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney St, London SW3 6NP , UK"},{"name":"National Heart and Lung Institute, Imperial College London 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