{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:34:57Z","timestamp":1769754897400,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020407","name":"European Research Area Network on Cardiovascular Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GENE POSITIVE"},{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCL Hospitals NIHR Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>A risk calculator for individualized prediction of first-time sustained ventricular arrhythmia (VA) in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients has recently been developed and validated (www.ARVCrisk.com). This study aimed to investigate whether regional functional abnormalities, measured by echocardiographic deformation imaging, can provide additional prognostic value.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>From two referral centres, 150 consecutive patients with a definite ARVC diagnosis, no prior sustained VA, and an echocardiogram suitable for deformation analysis were included (aged 41 \u00b1 17 years, 50% female). During a median follow-up of 6.3 (interquartile range 3.1\u20139.8) years, 37 (25%) experienced a first-time sustained VA. All tested left and right ventricular (LV and RV) deformation parameters were univariate predictors for first-time VA. While LV function did not add predictive value in multivariate analysis, two RV deformation parameters did; RV free wall longitudinal strain and regional RV deformation patterns remained independent predictors after adjusting for the calculator-predicted risk [hazard ratio 1.07 (95% CI 1.02\u20131.11); P = 0.004 and 4.45 (95% CI 1.07\u201318.57); P = 0.040, respectively] and improved its discriminative value (from C-statistic 0.78 to 0.82 in both; Akaike information criterion change &amp;gt; 2). Importantly, all patients who experienced VA within 5 years from the echocardiographic assessment had abnormal regional RV deformation patterns at baseline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study showed that regional functional abnormalities measured by echocardiographic deformation imaging can further refine personalized arrhythmic risk prediction when added to the ARVC risk calculator. The excellent negative predictive value of normal RV deformation could support clinicians considering the timing of implantable cardioverter defibrillator implantation in patients with intermediate arrhythmic risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead174","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T01:41:21Z","timestamp":1689903681000},"page":"1710-1718","source":"Crossref","is-referenced-by-count":8,"title":["The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1350-8765","authenticated-orcid":false,"given":"Feddo P","family":"Kirkels","sequence":"first","affiliation":[{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Centre Utrecht , Heidelberglaan 100, Utrecht 3582 CX , The Netherlands"},{"name":"Netherlands Heart 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Heart and Lungs, Department of Cardiology, University Medical Centre Utrecht , Heidelberglaan 100, Utrecht 3582 CX , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eivind W","family":"Aabel","sequence":"additional","affiliation":[{"name":"ProCardio Centre for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet , Oslo , Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Muller","sequence":"additional","affiliation":[{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Centre Utrecht , Heidelberglaan 100, Utrecht 3582 CX , The Netherlands"},{"name":"Netherlands Heart Institute , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna I","family":"Castrini","sequence":"additional","affiliation":[{"name":"ProCardio Centre 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H","family":"Lie","sequence":"additional","affiliation":[{"name":"ProCardio Centre for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert W","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Centre, University of Amsterdam , Amsterdam , The Netherlands"},{"name":"Health Data Research UK and Institute of Health Informatics, University College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8129-7384","authenticated-orcid":false,"given":"Joost","family":"Lumens","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneline S J 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