{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:20:37Z","timestamp":1791354037967,"version":"4.3.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Clinical research Unit"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>His-bundle pacing has emerged as a novel method to deliver cardiac resynchronization therapy (CRT). However, there are no data comparing conventional biventricular (BiV)-CRT with His-CRT with regard to effects on mechanical dyssynchrony and longitudinal contractile function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients with symptomatic heart failure, left ventricular ejection fraction \u2264 35%, and left bundle branch block (LBBB) by strict ECG criteria were randomized 1:1 to His-CRT or BiV-CRT. Two-dimensional strain echocardiography was performed prior to CRT implantation and at 6 months after implantation. Differences in changes in mechanical dyssynchrony (standard deviation of time-to-peak in 12 midventricular and basal segments) and regional longitudinal strain in the six left ventricular walls were compared between the BiV-CRT and His-CRT groups.<\/jats:p>\n                  <jats:p>In the on-treatment analysis, 31 received BiV-CRT and 19 His-CRT. In both groups, mechanical dyssynchrony was significantly reduced after 6 months [BiV group from 120 ms (\u00b145) to 63 ms (\u00b122), P &amp;lt; 0.001, and His group from 116 ms (\u00b154) to 49 ms (\u00b111), P &amp;lt; 0.001] but no significant differences in changes could be demonstrated between groups [\u22129.0 ms (\u221236; 18), P = 0.50]. Global longitudinal strain (GLS) improved in both groups [BiV group from \u22129.1% (\u00b12.7) to \u221210.7% (\u00b12.6), P = 0.02, and His group from \u22128.6% (\u00b12.1) to \u221211.1% (\u00b12.0), P &amp;lt; 0.001], but no significant differences in changes could be demonstrated from baseline to follow-up [\u22120.9% (\u22122.4; \u22120.6), P = 0.25] between groups. There were no regional differences between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In heart failure, patients with LBBB, BiV-CRT, and His-CRT have comparable effects with regard to improvements in mechanical dyssynchrony and longitudinal contractile function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead181","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T15:52:12Z","timestamp":1690300332000},"page":"66-74","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy on resynchronization and longitudinal contractile function comparing His-bundle pacing with conventional biventricular pacing: a substudy to the His-alternative study"],"prefix":"10.1093","volume":"25","author":[{"given":"E V","family":"H\u00f8jgaard","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Co penhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-7601","authenticated-orcid":false,"given":"B T","family":"Philbert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Co penhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-5098","authenticated-orcid":false,"given":"J J","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Co penhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-9555","authenticated-orcid":false,"given":"U C","family":"Winsl\u00f8w","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Co penhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-8515","authenticated-orcid":false,"given":"J H","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Co penhagen , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-688X","authenticated-orcid":false,"given":"M","family":"Vinther","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Co penhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-9164","authenticated-orcid":false,"given":"N","family":"Risum","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, 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